Differential stability of DNA based on salt concentration
Soft Condensed Matter
2016-04-25 v2 Biological Physics
Abstract
Intracellular positive ions neutralise negative charges on the phosphates of a DNA strand conferring greater strength on the hydrogen bonds that connect complementary strands into a double helix and so confer enhanced stability. Beyond a certain value of salt concentration, the DNA molecule displays a unstable nature {\it in vivo} as well as {\it in vitro}. We consider a wide range of salt concentrations and study the stability of the DNA double helix using a statistical model. Through numerical calculations we attempt to explain the different behaviour exhibited by DNA molecules in this range. We compare our results with experimental data and find a close agreement.
Keywords
Cite
@article{arxiv.1508.04528,
title = {Differential stability of DNA based on salt concentration},
author = {Arghya Maity and Amar Singh and Navin Singh},
journal= {arXiv preprint arXiv:1508.04528},
year = {2016}
}