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We introduce a new way to study molecular evolution within well-established Hamilton-Jacobi formalism, showing that for a broad class of fitness landscapes it is possible to derive dynamics analytically within the $1/N$-accuracy, where $N$…

Populations and Evolution · Quantitative Biology 2015-05-13 David B. Saakian , Olga Rozanova , Andrei Akmetzhanov

We study the asymptotic behavior of an integro-dierential equation describing the evolutionary adaptation of a population structured by a phenotypic trait. The model takes into account mutation, selection, horizontal gene transfer and…

Analysis of PDEs · Mathematics 2026-04-03 Alejandro Gárriz , Sepideh Mirrahimi

We considered a {multi-block} molecular model of biological evolution, in which fitness is a function of the mean types of alleles located at different parts (blocks) of the genome. We formulated an infinite population model with selection…

Populations and Evolution · Quantitative Biology 2015-06-12 David B. Saakian , Zara Kirakosyan , Chin-Kun Hu

In this work, we characterize the solution of a system of elliptic integro-differential equations describing a phenotypically structured population subject to mutation, selection and migration between two habitats. Assuming that the effects…

Analysis of PDEs · Mathematics 2016-12-20 Sepideh Mirrahimi

We consider finite population size effects for Crow-Kimura and Eigen quasispecies models with single peak fitness landscape. We formulate accurately the iteration procedure for the finite population models, then derive Hamilton-Jacobi…

Populations and Evolution · Quantitative Biology 2015-06-12 David B. Saakian , Michael W. Deem , Chin Kun Hu

In this paper, we study an integro-differential equation which describes the evolutionary dynamics of a population structured by a phenotypic trait. This population undergoes asexual reproduction, competition, selection, and mutation. We…

Analysis of PDEs · Mathematics 2025-11-18 Caroline Guinet , Sepideh Mirrahimi , Jean-Michel Roquejoffre

This work presents a population genetic model of evolution, which includes haploid selection, mutation, recombination, and drift. The mutation-selection equilibrium can be expressed exactly in closed form for arbitrary fitness functions…

Populations and Evolution · Quantitative Biology 2023-02-28 Jenny M. Poulton , Lee Altenberg , Chris Watkins

We introduce a generalization of the parallel, or Crow-Kimura, and Eigen models of molecular evolution to represent the exchange of genetic information between individuals in a population. We study the effect of different schemes of genetic…

Populations and Evolution · Quantitative Biology 2009-11-13 Enrique Munoz , Jeong-Man Park , Michael W. Deem

In this note, we characterize the solution of a system of elliptic integro-differential equations describing a phe-notypically structured population subject to mutation, selection and migration. Generalizing an approach based on…

Analysis of PDEs · Mathematics 2018-05-25 Sepideh Mirrahimi , Sylvain Gandon

We consider the evolution of large but finite populations on arbitrary fitness landscapes. We describe the evolutionary process by a Markov, Moran process. We show that to $\mathcal O(1/N)$, the time-averaged fitness is lower for the finite…

Populations and Evolution · Quantitative Biology 2015-06-04 Dirk M. Lorenz , Jeong-Man Park , Michael W. Deem

We study an equation structured by age and a phenotypic trait describing the growth process of a population subject to aging, competition between individuals, and mutations. This leads to a renewal equation which occurs in many evolutionary…

Analysis of PDEs · Mathematics 2020-01-14 Samuel Nordmann , Benoît Perthame

We study a mathematical model describing the growth process of a population structured by age and a phenotypical trait, subject to aging, competition between individuals and rare mutations. Our goals are to describe the asymptotic behaviour…

Analysis of PDEs · Mathematics 2020-04-17 Samuel Nordmann , Benoît Perthame , Cécile Taing

Following previous works about integro-differential equations of parabolic type modelling the Darwinian evolution of a population, we study a two-population system in the cooperative case. First, we provide a theoretical study of the limit…

Analysis of PDEs · Mathematics 2021-12-03 Alexis Leculier , Pierre Roux

The evolution model with parallel mutation-selection scheme is solved for the case when selection is accompanied by base substitutions, insertions, and deletions. The fitness is assumed to be either a single-peak function (i.e., having one…

Populations and Evolution · Quantitative Biology 2015-05-13 D. B. Saakian

We consider an asexual population under strong selection-weak mutation conditions evolving on rugged fitness landscapes with many local fitness peaks. Unlike the previous studies in which the initial fitness of the population is assumed to…

Populations and Evolution · Quantitative Biology 2011-11-18 Kavita Jain , Sarada Seetharaman

Horizontal gene transfer is an important factor in bacterial evolution that can act across species boundaries. Yet, we know little about rate and genomic targets of cross-lineage gene transfer, and about its effects on the recipient…

Populations and Evolution · Quantitative Biology 2022-10-12 Jeffrey J. Power , Fernanda Pinheiro , Simone Pompei , Viera Kovacova , Melih Yüksel , Isabel Rathmann , Mona Förster , Michael Lässig , Berenike Maier

We introduce a Markov model for the evolution of a gene family along a phylogeny. The model includes parameters for the rates of horizontal gene transfer, gene duplication, and gene loss, in addition to branch lengths in the phylogeny. The…

Populations and Evolution · Quantitative Biology 2016-09-08 Miklós Csűrös , István Miklós

We present a novel approach to performing fitness approximation in genetic algorithms (GAs) using machine-learning (ML) models, through dynamic adaptation to the evolutionary state. Maintaining a dataset of sampled individuals along with…

Neural and Evolutionary Computing · Computer Science 2024-05-22 Itai Tzruia , Tomer Halperin , Moshe Sipper , Achiya Elyasaf

We consider a stochastic model for the evolution of a discrete population structured by a trait with values on a finite grid of the torus, and with mutation and selection. Traits are vertically inherited unless a mutation occurs, and…

Probability · Mathematics 2022-06-17 Nicolas Champagnat , Sylvie Méléard , Sepideh Mirrahimi , Viet Chi Tran

Predicting the adaptation of populations to a changing environment is crucial to assess the impact of human activities on biodiversity. Many theoretical studies have tackled this issue by modeling the evolution of quantitative traits…

Analysis of PDEs · Mathematics 2022-06-28 Jimmy Garnier , O Cotto , T Bourgeron , E Bouin , T Lepoutre , O Ronce , V Calvez
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