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DNA-binding proteins are a class of proteins which have a specific or general affinity to DNA and include three important components: transcription factors; nucleases, and histones. DNA-binding proteins also perform important roles in many…

Computer Vision and Pattern Recognition · Computer Science 2012-07-12 Sokyna Qatawneh , Afaf Alneaimi , Thamer Rawashdeh , Mmohammad Muhairat , Rami Qahwaji , Stan Ipson

A fundamental question in systems biology is the construction and training to data of mathematical models. Logic formalisms have become very popular to model signaling networks because their simplicity allows us to model large systems…

Quantitative Methods · Quantitative Biology 2012-12-27 Santiago Videla , Carito Guziolowski , Federica Eduati , Sven Thiele , Niels Grabe , Julio Saez-Rodriguez , Anne Siegel

Mass spectrometry provides a high-throughput way to identify proteins in biological samples. In a typical experiment, proteins in a sample are first broken into their constituent peptides. The resulting mixture of peptides is then subjected…

Applications · Statistics 2010-11-10 Qunhua Li , Michael J. MacCoss , Matthew Stephens

The use of patterns in predictive models is a topic that has received a lot of attention in recent years. Pattern mining can help to obtain models for structured domains, such as graphs and sequences, and has been proposed as a means to…

Artificial Intelligence · Computer Science 2011-11-29 Björn Bringmann , Siegfried Nijssen , Albrecht Zimmermann

Network theory has proven invaluable in unraveling complex protein interactions. Previous studies have employed statistical methods rooted in network theory, including the Gaussian graphical model, to infer networks among proteins,…

Methodology · Statistics 2026-05-07 Seungjun Ahn , Eun Jeong Oh

Magnetic resonance imaging (MRI) is the non-invasive modality of choice for body tissue composition analysis due to its excellent soft tissue contrast and lack of ionizing radiation. However, quantification of body composition requires an…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Ismail Irmakci , Sarfaraz Hussein , Aydogan Savran , Rita R. Kalyani , David Reiter , Chee W. Chia , Kenneth W. Fishbein , Richard G. Spencer , Luigi Ferrucci , Ulas Bagci

Protein threading is a method of computational protein structure prediction used for protein sequences which have the same fold as proteins of known structures but do not have homologous proteins with known structure. The most popular…

Data Structures and Algorithms · Computer Science 2013-10-17 Wajeb Gharibi , Marwah Mohammed Bakri

This research aims to examine the usefulness of integrating various feature selection methods with regression algorithms for sleep quality prediction. A publicly accessible sleep quality dataset is used to analyze the effect of different…

Machine Learning · Computer Science 2023-03-07 Sai Rohith Tanuku , Venkat Tummala

Data classification techniques partition the data or feature space into smaller sub-spaces, each corresponding to a specific class. To classify into subspaces, physical features e.g., distance and distributions are utilized. This approach…

Machine Learning · Computer Science 2025-03-11 Josimar Chire , Khalid Mahmood , Zhao Liang

Sequential pattern mining algorithms are widely used to explore care pathways database, but they generate a deluge of patterns, mostly redundant or useless. Clinicians need tools to express complex mining queries in order to generate less…

Artificial Intelligence · Computer Science 2017-07-27 Thomas Guyet , André Happe , Yann Dauxais

Many aspects of the study of protein folding and dynamics have been affected by the recent advances in machine learning. Methods for the prediction of protein structures from their sequences are now heavily based on machine learning tools.…

Biological Physics · Physics 2019-11-25 Frank Noé , Gianni De Fabritiis , Cecilia Clementi

Recently developed deep learning techniques have significantly improved the accuracy of various speech and image recognition systems. In this paper we adapt some of these techniques for protein secondary structure prediction. We first train…

Machine Learning · Computer Science 2016-11-07 Akosua Busia , Jasmine Collins , Navdeep Jaitly

The goal of constraint-based sequence mining is to find sequences of symbols that are included in a large number of input sequences and that satisfy some constraints specified by the user. Many constraints have been proposed in the…

Artificial Intelligence · Computer Science 2015-02-26 Benjamin Negrevergne , Tias Guns

We introduce an algorithm for the alignment of protein- coding sequences accounting for frameshifts. The main specificity of this algorithm as compared to previously published protein-coding sequence alignment methods is the introduction of…

Data Structures and Algorithms · Computer Science 2015-08-21 François Bélanger , Aïda Ouangraoua

Protein inference plays a vital role in the proteomics study. Two major approaches could be used to handle the problem of protein inference; top-down and bottom-up. This paper presents a framework for protein inference, which uses hardware…

Computational Engineering, Finance, and Science · Computer Science 2014-03-07 S. M. Vidanagamachchi , S. D. Dewasurendra , R. G. Ragel

We investigate whether synthetic images generated by diffusion models can enhance multi-label classification of protein subcellular localization. Specifically, we implement a simplified class-conditional denoising diffusion probabilistic…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Sylvey Lin , Zhi-Yi Cao

Fuzzing is a popular dynamic program analysis technique used to find vulnerabilities in complex software. Fuzzing involves presenting a target program with crafted malicious input designed to cause crashes, buffer overflows, memory errors,…

Software Engineering · Computer Science 2017-11-15 Mohit Rajpal , William Blum , Rishabh Singh

This paper presents an effective method for fingerprint classification using data mining approach. Initially, it generates a numeric code sequence for each fingerprint image based on the ridge flow patterns. Then for each class, a seed is…

Computer Vision and Pattern Recognition · Computer Science 2012-11-21 Monowar H. Bhuyan , Sarat Saharia , Dhruba Kr Bhattacharyya

Computational protein design, i.e. inferring novel and diverse protein sequences consistent with a given structure, remains a major unsolved challenge. Recently, deep generative models that learn from sequences alone or from sequences and…

Biomolecules · Quantitative Biology 2021-11-15 Igor Melnyk , Payel Das , Vijil Chenthamarakshan , Aurelie Lozano

This paper describes a method to efficiently retrieve protein database sequences similar to a query sequence, while allowing for significant numbers of mutations. We call this method SEQR for SEQuence Retrieval. This approach increases the…

Genomics · Quantitative Biology 2018-11-05 David I. Hurwitz , Lianyi Han , Lewis Y. Geer