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Despite the large number of patients in Electronic Health Records (EHRs), the subset of usable data for modeling outcomes of specific phenotypes are often imbalanced and of modest size. This can be attributed to the uneven coverage of…

Machine Learning · Computer Science 2021-03-25 Mohamed Ghalwash , Zijun Yao , Prithwish Chakraborty , James Codella , Daby Sow

Community annotation of biological entities with concepts from multiple bio-ontologies has created large and growing repositories of ontology-based annotation data with embedded implicit relationships among orthogonal ontologies.…

Artificial Intelligence · Computer Science 2016-05-17 Prashanti Manda , Fiona McCarthy , Bindu Nanduri , Hui Wang , Susan M. Bridges

This paper studies the role that ontologies can play in establishing conceptual data models during the process of information systems development. A mapping algorithm has been proposed and embedded in a special purpose Transformation-Engine…

Software Engineering · Computer Science 2007-05-23 Haya El-Ghalayini , Mohammed Odeh , Richard McClatchey

Large language models have achieved great success in multiple challenging tasks, and their capacity can be further boosted by the emerging agentic AI techniques. This new computing paradigm has already started revolutionising the…

Machine Learning · Computer Science 2026-03-23 Cen Wan , Alex A. Freitas

Clinical AI systems routinely train on health data structurally distorted by documentation workflows, billing incentives, and terminology fragmentation. Prior work has characterised the mechanisms of this distortion: the three-forces model…

Artificial Intelligence · Computer Science 2026-04-03 Florian Odi Stummer

Motivation: Predicting gene-disease associations (GDAs) is the problem to determine which gene is associated with a disease. GDA prediction can be framed as a ranking problem where genes are ranked for a query disease, based on features…

Quantitative Methods · Quantitative Biology 2026-02-03 Fernando Zhapa-Camacho , Robert Hoehndorf

We propose a novel framework to facilitate the on-demand design of data-centric systems by exploiting domain knowledge from an existing ontology. Its key ingredient is a process that we call focusing, which allows to obtain a schema for a…

Logic in Computer Science · Computer Science 2019-04-02 Tomasz Gogacz , Víctor Gutiérrez-Basulto , Yazmín A. Ibáñez-García , Filip Murlak , Magdalena Ortiz , Mantas Šimkus

Genetic dispositions play a major role in individual disease risk and treatment response. Genomic medicine, in which medical decisions are refined by genetic information of particular patients, is becoming increasingly important. Here we…

Other Computer Science · Computer Science 2011-09-30 Matthias Samwald , Holger Stenzhorn , Michel Dumontier , M. Scott Marshall , Joanne Luciano , Klaus-Peter Adlassnig

The healthcare industry is moving towards a patient-centric paradigm that requires advanced methods for managing and representing patient data. This paper presents a Patient Journey Ontology (PJO), a framework that aims to capture the…

Databases · Computer Science 2025-06-25 Hassan S. Al Khatib , Subash Neupane , Sudip Mittal , Shahram Rahimi , Nina Marhamati , Sean Bozorgzad

Big data solutions are designed to cope with data of huge Volume and wide Variety, that need to be ingested at high Velocity and have potential Veracity issues, challenging characteristics that are usually referred to as the "4Vs of Big…

Artificial Intelligence · Computer Science 2019-04-19 Maximilian Zocholl , Elena Camossi , Anne-Laure Jousselme , Cyril Ray

The connection between the design and delivery of health care services using information technology is known as health informatics. It involves data usage, validation, and transfer of an integrated medical analysis using neural networks of…

Quantitative Methods · Quantitative Biology 2022-08-08 Amin Gasmi

Digital pathology is not only one of the most promising fields of diagnostic medicine, but at the same time a hot topic for fundamental research. Digital pathology is not just the transfer of histopathological slides into digital…

Artificial Intelligence · Computer Science 2017-12-20 Andreas Holzinger , Bernd Malle , Peter Kieseberg , Peter M. Roth , Heimo Müller , Robert Reihs , Kurt Zatloukal

Discovery gene-disease links is important in biology and medicine areas, enabling disease identification and drug repurposing. Machine learning approaches accelerate this process by leveraging biological knowledge represented in ontologies…

Machine Learning · Computer Science 2025-04-14 Catarina Canastra , Cátia Pesquita

Diabetes is one of the chronic diseases, which is increasing from year to year. The problems begin when diabetes is not detected at an early phase and diagnosed properly at the appropriate time. Different machine learning techniques, as…

Databases · Computer Science 2024-06-03 Hakim El Massari , Zineb Sabouri , Sajida Mhammedi , Noreddine Gherabi

Ontologies are widely used for representing domain knowledge and meta data, playing an increasingly important role in Information Systems, the Semantic Web, Bioinformatics and many other domains. However, logical reasoning that ontologies…

Artificial Intelligence · Computer Science 2025-04-08 Jiaoyan Chen , Olga Mashkova , Fernando Zhapa-Camacho , Robert Hoehndorf , Yuan He , Ian Horrocks

Personalised medicine strives to identify the right treatment for the right patient at the right time, integrating different types of biological and environmental information. Such information come from a variety of sources: omics data…

Applications · Statistics 2014-01-14 Marco Scutari

Identifying disease genes from human genome is an important and fundamental problem in biomedical research. Despite many publications of machine learning methods applied to discover new disease genes, it still remains a challenge because of…

Quantitative Methods · Quantitative Biology 2017-05-23 Peng Yang

Artificial Intelligence (AI) has already made a huge impact on our current technological trends. Through AI developments, machines are now given power and intelligence to behave and work like human mind. In this research project, we propose…

Computers and Society · Computer Science 2018-08-07 Rida Sara Khan , Asad Ali Zardar , Zeeshan Bhatti

Rapid growth of documents, web pages, and other types of text content is a huge challenge for the modern content management systems. One of the problems in the areas of information storage and retrieval is the lacking of semantic data.…

Databases · Computer Science 2015-02-23 Mona Dadjoo , Esmaeil Kheirkhah

In biomedical research, unified access to up-to-date domain-specific knowledge is crucial, as such knowledge is continuously accumulated in scientific literature and structured resources. Identifying and extracting specific information is a…

Information Retrieval · Computer Science 2020-06-03 Anastasios Nentidis , Konstantinos Bougiatiotis , Anastasia Krithara , Georgios Paliouras
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