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Sequential monitoring in clinical trials is often employed to allow for early stopping and other interim decisions, while maintaining the type I error rate. However, sequential monitoring is typically described only in the context of a…

Statistics Theory · Mathematics 2012-05-29 Victoria Plamadeala , William F. Rosenberger

Experimental evaluations of public policies often randomize a new intervention within many sites or blocks. After a report of an overall result -- statistically significant or not -- the natural question from a policy maker is: \emph{where}…

Methodology · Statistics 2026-03-02 Jake Bowers , David Kim , Nuole Chen

In this paper, we develop a simple approach for testing multiple statistical hypotheses based on the observations of a number of probability ratios enumerated consecutively with respect to the index of hypotheses. Explicit and tight bounds…

Statistics Theory · Mathematics 2012-06-19 Xinjia Chen

Several interesting models for contingency tables are defined by a system of equality and inequality constraints on a suitable set of marginal log-linear parameters. After reviewing the most common difficulties which are intrinsic to order…

Statistics Theory · Mathematics 2014-01-09 Roberto Colombi , Antonio Forcina

Assessing the stability of a multiple testing procedure under dependence is important but very challenging. Even for multiple testing which among a set of Normal random variables have mean zero, which we refer to as the "Normal means…

Statistics Theory · Mathematics 2020-03-06 Xiongzhi Chen , Rebecca W. Doerge

False discovery rate (FDR) is a cornerstone of modern multiple testing. However, it often fails to guarantee the reliability of "marginal" discoveries that lie at the boundary of the rejection set, which are often crucial in high-precision…

Methodology · Statistics 2026-05-12 Yifan Zhang , Wentao Zhang , Changliang Zou , Haojie Ren

To analyse a very large data set containing lengthy variables, we adopt a sequential estimation idea and propose a parallel divide-and-conquer method. We conduct several conventional sequential estimation procedures separately, and properly…

Methodology · Statistics 2018-12-27 Zhanfeng Wang , Yuan-chin Ivan Chang

After initial release of a machine learning algorithm, the model can be fine-tuned by retraining on subsequently gathered data, adding newly discovered features, or more. Each modification introduces a risk of deteriorating performance and…

Machine Learning · Statistics 2022-03-23 Jean Feng , Gene Pennello , Nicholas Petrick , Berkman Sahiner , Romain Pirracchio , Alexej Gossmann

Familywise error rate (FWER) has been a cornerstone in simultaneous inference for decades, and the classical Bonferroni method has been one of the most prominent frequentist approaches for controlling FWER. The present article studies the…

Statistics Theory · Mathematics 2022-01-27 Monitirtha Dey

The problem of multiple endpoint testing for k endpoints is treated as a 2^k finite action problem. The loss function chosen is a vector loss function consisting of two components. The two components lead to a vector risk. One component of…

Statistics Theory · Mathematics 2007-06-13 Arthur Cohen , Harold B. Sackrowitz

We analyze control of the familywise error rate (FWER) in a multiple testing scenario with a great many null hypotheses about the distribution of a high-dimensional random variable among which only a very small fraction are false, or…

Methodology · Statistics 2015-09-15 Kamel Lahouel , Donald Geman , Laurent Younes

Despite the popularity of the false discovery rate (FDR) as an error control metric for large-scale multiple testing, its close Bayesian counterpart the local false discovery rate (lfdr), defined as the posterior probability that a…

Methodology · Statistics 2023-09-22 Jake A. Soloff , Daniel Xiang , William Fithian

We consider the problem of sequential evaluation, in which an evaluator observes candidates in a sequence and assigns scores to these candidates in an online, irrevocable fashion. Motivated by the psychology literature that has studied…

Machine Learning · Statistics 2023-11-20 Jingyan Wang , Ashwin Pananjady

Anomaly detection aims at detecting unexpected behaviours in the data. Because anomaly detection is usually an unsupervised task, traditional anomaly detectors learn a decision boundary by employing heuristics based on intuitions, which are…

Machine Learning · Computer Science 2023-10-19 Lorenzo Perini , Jesse Davis

Typically, fault-tolerant operations and code concatenation are reserved for quantum error correction due to their resource overhead. Here, we show that fault tolerant operations have a large impact on the performance of symmetry based…

Quantum Physics · Physics 2024-07-19 Alvin Gonzales , Anjala M Babu , Ji Liu , Zain Saleem , Mark Byrd

We propose sufficient conditions and computationally efficient procedures for false discovery rate control in multiple testing when the $p$-values are related by a known \emph{dependency graph} -- meaning that we assume independence of…

Methodology · Statistics 2025-07-01 Drew T. Nguyen , William Fithian

In the binary hypothesis testing problem, it is well known that sequentiality in taking samples eradicates the trade-off between two error exponents, yet implementing the optimal test requires the knowledge of the underlying distributions,…

Information Theory · Computer Science 2025-01-07 Ching-Fang Li , I-Hsiang Wang

Online evaluation of machine learning models is typically conducted through A/B experiments. Sequential statistical tests are valuable tools for analysing these experiments, as they enable researchers to stop data collection early without…

Methodology · Statistics 2025-10-08 Alexey Kurennoy , Majed Dodin , Tural Gurbanov , Ana Peleteiro Ramallo

Rejection sampling is a common tool for low dimensional problems ($d \leq 2$), often touted as an "easy" way to obtain valid samples from a distribution $f(\cdot)$ of interest. In practice it is non-trivial to apply, often requiring…

Computation · Statistics 2023-10-03 Edward Raff , Mark McLean , James Holt

In this paper, we propose a broad and general sequential sampling scheme, which incorporates four different types of sampling procedures: i) the classic Anscombe-Chow-Robbins purely sequential sampling procedure; ii) the ordinary…

Methodology · Statistics 2022-07-18 Jun Hu , Yan Zhuang