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An astonishingly diverse biomolecular circuitry orchestrates the functioning machinery underlying every living cell. These biomolecules and their circuits have been engineered not only for various industrial applications but also to perform…

Biomolecules · Quantitative Biology 2021-02-15 Sahana Gangadharan , Karthik Raman

With the completion of human genome mapping, the focus of scientists seeking to explain the biological complexity of living systems is shifting from analyzing the individual components (such as a particular gene or biochemical reaction) to…

Molecular Networks · Quantitative Biology 2010-01-28 Sitabhra Sinha , T Jesan , Nivedita Chatterjee

At its core, the physics paradigm adopts a reductionist approach, aiming to understand fundamental phenomena by decomposing them into simpler, elementary processes. While this strategy has been tremendously successful in physics, it has…

Biological Physics · Physics 2025-12-10 Ramón Nartallo-Kaluarachchi , Renaud Lambiotte , Alain Goriely

There are inherent limits in classical computation for it to serve as an adequate model of human cognition. In particular, non-commutativity, while ubiquitous in physics and psychology, cannot be sufficiently handled. We propose that we…

Neurons and Cognition · Quantitative Biology 2019-11-14 Hongbin Wang , Jack W. Smith , Yanlong Sun

Composition is a powerful principle for systems biology, focused on the interfaces, interconnections, and orchestration of distributed processes to enable integrative multiscale simulations. Whereas traditional models focus on the structure…

Other Quantitative Biology · Quantitative Biology 2024-11-25 Eran Agmon

This text introduces the twin deadlocks of strong artificial life. Conceptualization of life is a deadlock both because of the existence of a continuum between the inert and the living, and because we only know one instance of life.…

Artificial Intelligence · Computer Science 2007-05-23 J. -Ph Rennard

Integration between biology and information science benefits both fields. Many related models have been proposed, such as computational visual cognition models, computational motor control models, integrations of both and so on. In general,…

Computer Vision and Pattern Recognition · Computer Science 2016-03-28 Peijie Yin , Hong Qiao , Wei Wu , Lu Qi , YinLin Li , Shanlin Zhong , Bo Zhang

We start by an introduction to the basic concepts of computability theory and the introduction of the concept of Turing machine and computation universality. Then se turn to the exploration of trade-offs between different measures of…

Computational Complexity · Computer Science 2011-04-19 Joost J. Joosten , Fernando Soler-Toscano , Hector Zenil

The question What is Complexity? has occupied a great deal of time and paper over the last 20 or so years. There are a myriad different perspectives and definitions but still no consensus. In this paper I take a phenomenological approach,…

Adaptation and Self-Organizing Systems · Physics 2015-02-12 Christopher R. Stephens

We approach the question "What is Consciousness?" in a new way, not as Descartes' "systematic doubt", but as how organisms find their way in their world. Finding one's way involves finding possible uses of features of the world that might…

Physics and Society · Physics 2022-06-30 Stuart A. Kauffman , Andrea Roli

Mathematical models connect theory with the real world through data, enabling us to interpret, understand, and predict complex phenomena. However, scientific knowledge often extends beyond what can be empirically measured, offering valuable…

Predictive coding (PC) is an influential computational model of visual learning and inference in the brain. Classical PC was proposed as a top-down generative model, where the brain actively predicts upcoming visual inputs, and inference…

Machine Learning · Computer Science 2025-12-18 Gaspard Oliviers , Mufeng Tang , Rafal Bogacz

We argue that traditional Western science cannot adequately describe sports and other types of human behavior. Then we make an argument why a complex adaptive systems approach has the potential to provide the foundation for such a theory.…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Gottfried Mayer-Kress

This paper aims to justify the concept of natural intelligence, the type of intelligence wider than human intelligence and its derivative, AI. I will argue that the process of life is a cognitive process and that organisms, from bacteria to…

Other Quantitative Biology · Quantitative Biology 2020-01-07 P Slijepcevic

Neuromorphic computing is a non-von Neumann computing paradigm that performs computation by emulating the human brain. Neuromorphic systems are extremely energy-efficient and known to consume thousands of times less power than CPUs and…

Neural and Evolutionary Computing · Computer Science 2021-04-30 Prasanna Date , Catherine Schuman , Bill Kay , Thomas Potok

While Artificial Neural Networks (ANNs) have yielded impressive results in the realm of simulated intelligent behavior, it is important to remember that they are but sparse approximations of Biological Neural Networks (BNNs). We go beyond…

Neural and Evolutionary Computing · Computer Science 2021-03-30 Krishna Katyal , Jesse Parent , Bradly Alicea

Turing computability is the standard computability paradigm which captures the computational power of digital computers. To understand whether one can create physically realistic devices which have super-Turing power, one needs to…

Logic · Mathematics 2021-10-01 Daniel S. Graça , Ning Zhong

While evolution has inspired algorithmic methods of heuristic optimisation, little has been done in the way of using concepts of computation to advance our understanding of salient aspects of biological phenomena. We argue that under…

Computational Complexity · Computer Science 2012-06-05 Hector Zenil , James A. R. Marshall

The claim that life is an emergent phenomenon exhibiting novel properties and principles is often criticized for being in conflict with causal closure at the microscopic level. I argue that advances in cosmological theory suggesting an…

Astrophysics · Physics 2007-05-23 P. C. W. Davies

As deep learning systems are scaled up to many billions of parameters, relating their internal structure to external behaviors becomes very challenging. Although daunting, this problem is not new: Neuroscientists and cognitive scientists…