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Spiking neural networks (SNN) are artificial computational models that have been inspired by the brain's ability to naturally encode and process information in the time domain. The added temporal dimension is believed to render them more…
Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both…
Almost all neural computations involve making predictions. Whether an organism is trying to catch prey, avoid predators, or simply move through a complex environment, the data it collects through its senses can guide its actions only to the…
Much of studies on neural computation are based on network models of static neurons that produce analog output, despite the fact that information processing in the brain is predominantly carried out by dynamic neurons that produce discrete…
Spiking neural networks (SNNs), a brain-inspired computing paradigm, are emerging for their inference performance, particularly in terms of energy efficiency and latency attributed to the plasticity in signal processing. To deploy SNNs in…
Spike generation in neurons produces a temporal point process, whose statistics is governed by intrinsic phenomena and the external incoming inputs to be coded. In particular, spike-evoked adaptation currents support a slow temporal process…
In the last century, most sensorimotor studies of cortical neurons relied on average firing rates. Rate coding is efficient for fast sensorimotor processing that occurs within a few seconds. Much less is known about the neural mechanisms…
Driven by analogies with state vectors of quantum informatics and noise-based logic, we propose a general scheme and elements of neural circuitry for processing and addressing information in the brain. Specifically, we consider random…
Hippocampal neurons exhibit precise phase locking to network oscillations, but the computational principle governing this temporal precision is still unclear. Neural information is conveyed jointly by firing rates and spike timing, but…
Frequency discrimination is a fundamental task of the auditory system. The mammalian inner ear, or cochlea, provides a place code in which different frequencies are detected at different spatial locations. However, a temporal code based on…
Neurons in the nervous system are submitted to distinct sources of noise, such as ionic-channel and synaptic noise, which introduces variability in their responses to repeated presentations of identical stimuli. This motivates the use of…
We examine how the prior probability distribution of a sensory variable in the environment influences the optimal allocation of neurons and spikes in a population that represents that variable. We start with a conventional response model,…
The sensory-triggered activity of a neuron is typically characterized in terms of a tuning curve, which describes the neuron's average response as a function of a parameter that characterizes a physical stimulus. What determines the shapes…
Efficient planning and sequence selection are central to intelligence, yet current approaches remain largely incompatible with biological computation. Classical graph algorithms like Dijkstra's or A* require global state and biologically…
An increasing body of evidence suggests that the trial-to-trial variability of spiking activity in the brain is not mere noise, but rather the reflection of a sampling-based encoding scheme for probabilistic computing. Since the precise…
Advancing our knowledge of how the brain processes information remains a key challenge in neuroscience. This thesis combines three different approaches to the study of the dynamics of neural networks and their encoding representations: a…
To compensate for sensory processing delays, the visual system must make predictions to ensure timely and appropriate behaviors. Recent work has found predictive information about the stimulus in neural populations early in vision…
We address the problem of finding patterns from multi-neuronal spike trains that give us insights into the multi-neuronal codes used in the brain and help us design better brain computer interfaces. We focus on the synchronous firings of…
Neural population equations such as neural mass or field models are widely used to study brain activity on a large scale. However, the relation of these models to the properties of single neurons is unclear. Here we derive an equation for…
Spiking Neural Networks (SNNs), with their event-driven and biologically inspired operation, are well-suited for energy-efficient neuromorphic hardware. Neural coding, critical to SNNs, determines how information is represented via spikes.…