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The second phase accelerator for the Dual Axis Hydrodynamic Test facility (DARHT) is designed to provide an electron beam pulse that is 2 microsec long, 2kA, and 20 MeV in particle energy. The injector provides 3.2 MeV so that the linac…

The immunohistochemical (IHC) staining of the human epidermal growth factor receptor 2 (HER2) biomarker is widely practiced in breast tissue analysis, preclinical studies and diagnostic decisions, guiding cancer treatment and investigation…

The 1.7-GeV 100-mA CW proton linac is now under design for the Accelerator Production of Tritium (APT) Project. The APT linac comprises both the normal conducting (below 211 MeV) and superconducting (SC) sections. The high current leads to…

Prostate cancer diagnosis heavily relies on histopathological evaluation, which is subject to variability. While immunohistochemical staining (IHC) assists in distinguishing benign from malignant tissue, it involves increased work, higher…

Red-blood-cell lysis (HC50) is the principal safety barrier for antimicrobial-peptide (AMP) therapeutics, yet existing models only say "toxic" or "non-toxic." AmpLyze closes this gap by predicting the actual HC50 value from sequence alone…

Contrast-enhanced computed tomography angiograms (CTAs) are widely used in cardiovascular imaging to obtain a non-invasive view of arterial structures. However, contrast agents are associated with complications at the injection site as well…

Vehicle recognition is a fundamental problem in SAR image interpretation. However, robustly recognizing vehicle targets is a challenging task in SAR due to the large intraclass variations and small interclass variations. Additionally, the…

Early detection improves prognosis in pancreatic ductal adenocarcinoma (PDAC) but is challenging as lesions are often small and poorly defined on contrast-enhanced computed tomography scans (CE-CT). Deep learning can facilitate PDAC…

Data profiling has garnered increasing attention within the data science community, primarily focusing on structured data. In this paper, we introduce a novel framework called panacea, designed to profile known cancer target combinations in…

Cancer is one of the most life-threatening diseases worldwide, and head and neck (H&N) cancer is a prevalent type with hundreds of thousands of new cases recorded each year. Clinicians use medical imaging modalities such as computed…

Skin cancer is among the most prevalent and life-threatening diseases worldwide, with early detection being critical to patient outcomes. This work presents a hybrid machine and deep learning-based approach for classifying malignant and…

We present a global explainability method to characterize sources of errors in the histology prediction task of our real-world multitask convolutional neural network (MTCNN)-based deep abstaining classifier (DAC), for automated annotation…

Histology method is vital in the diagnosis and prognosis of cancers and many other diseases. For the analysis of histopathological images, we need to detect and segment all gland structures. These images are very challenging, and the task…

Proteolysis-targeting chimeras (PROTACs) represent a promising therapeutic modality that induces targeted protein degradation by hijacking the ubiquitin-proteasome system. However, rational PROTAC design remains challenging due to the…

The planned HL-LHC (High Luminosity LHC) in 2025 is being designed to maximise the physics potential through a sizable increase in the luminosity up to 6*10^34 cm^-2 s^-1. A consequence of this increased luminosity is the expected radiation…

Accurate and scalable cancer diagnosis remains a critical challenge in modern pathology, particularly for malignancies such as breast, prostate, bone, and cervical, which exhibit complex histological variability. In this study, we propose a…

The chemical abundances in damped Lyman-alpha systems (DLAs) show more than 2 orders of magnitude variation at a given epoch, possibly because DLAs arise in a wide variety of host galaxies. This could significantly bias estimates of…

Background: A subset of histo-blood group antigens including ABO and Lewis are oligosaccharide structures which may be conjugated to lipids or proteins. They are known to be important recognition motifs not only in the context of blood…

Despite their dynamic nature, certain chromatin marks must be maintained over the long term. This is particulary true for histone 3 lysine 9 (H3K9) trimethylation, that is involved in the maintenance of healthy differentiated cellular…

Spatial transcriptomics enables interrogating the molecular composition of tissue with ever-increasing resolution and sensitivity. However, costs, rapidly evolving technology, and lack of standards have constrained computational methods in…