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We present a Lagrangian analysis of turbulent blood flow in the human left heart using high-fidelity simulations based on a patient-specific anatomical model. Leveraging a fully coupled fluid-structure-electrophysiology interaction (FSEI)…

Fluid Dynamics · Physics 2025-06-13 Fabio Guglietta , Martino Andrea Scarpolini , Francesco Viola , Luca Biferale

Fast and realistic coupling of blood flow and vessel wall is of great importance to virtual surgery. In this paper, we propose a novel data-driven coupling method that formulates physics-based blood flow simulation as a regression problem,…

Graphics · Computer Science 2019-01-25 Xuejie Mai , Zhiyong Yuan , Qianqian Tong , Tianchen Yuan , Jianhui Zhao

Ultrafast power Doppler imaging (uPDI) has become a powerful tool for both research and clinical applications. However, existing simulation tools are insufficient for generating quantitatively accurate three-dimensional (3D) flow fields…

Signal Processing · Electrical Eng. & Systems 2025-10-28 Qiang Fu , Changhui Li

Due to the complexity of the traffic flow dynamics in urban road networks, most quantitative descriptions of city traffic so far are based on computer simulations. This contribution pursues a macroscopic (fluid-dynamic) simulation approach,…

Fluid Dynamics · Physics 2015-03-18 Amin Mazloumian , Nikolas Geroliminis , Dirk Helbing

The laboratory models of the human heart left ventricle developed in the last decades gave a valuable contribution to the comprehension of the role of the fluid dynamics in the cardiac function and to support the interpretation of the data…

Fluid Dynamics · Physics 2014-07-29 S. Fortini , G. Querzoli , S. Espa , A. Cenedese

The development and progression of abdominal aortic aneurysms (AAA) are related to complex flow patterns and wall-shear-driven mechanobiological stimuli, yet the quantitative relationship between aneurysmal geometry and hemodynamics remains…

Accurate three-dimensional (3D) reconstruction of cardiac chamber motion from time-resolved medical imaging modalities is of growing interest in both the clinical and biomechanical fields. Despite recent advancement, the cardiac motion…

Medical Physics · Physics 2025-04-18 Francesco Capuano , Yue-Hin Loke , Ibrahim Yildiran , Laura Olivieri , Elias Balaras

Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to…

Quantitative Methods · Quantitative Biology 2020-02-21 Megan J. Chambers , Mitchel J. Colebank , M Umar Qureshi , Rachel Clipp , Mette S. Olufsen

Numerical model of the peripheral circulation and dynamical model of the large vessels and the heart are discussed in this paper. They combined together into the global model of blood circulation. Some results of numerical simulations…

Biological Physics · Physics 2007-12-31 S. S. Simakov , A. S. Kholodov , A. V. Evdokimov , Y. A. Kholodov

An accurate assessment of the cardiovascular system and prediction of cardiovascular diseases (CVDs) are crucial. Measured cardiac blood flow data provide insights about patient-specific hemodynamics, where many specialized techniques have…

Recent developments in cardiovascular modelling allow us to simulate blood flow in an entire human body. Such model can also be used to create databases of virtual subjects, with sizes limited only by computational resources. In this work,…

Medical Physics · Physics 2020-07-01 Janne M. J. Huttunen , Leo Kärkkäinen , Harri Lindholm

In this paper, we are concerned with the simulation of blood flow in microvascular networks and the surrounding tissue. To reduce the computational complexity of this issue, the network structures are modeled by a one-dimensional graph,…

Numerical Analysis · Mathematics 2023-05-01 Ettore Vidotto , Timo Koch , Tobias Köppl , Rainer Helmig , Barbara Wohlmuth

Every sixth death in industrialised countries occurs because of cardiac arrhythmias like ventricular tachycardia (VT) and ventricular fibrillation (VF). There is growing consensus that VT is associated with an unbroken spiral wave of…

Pattern Formation and Solitons · Physics 2007-05-23 T K Shajahan , Sitabhra Sinha , Rahul Pandit

Hemodynamics in the aorta from computational fluid dynamics (CFD) simulations can provide a comprehensive analysis of relevant cardiovascular diseases. Coupling the three-element Windkessel model with the patient-specific CFD simulation to…

Fluid Dynamics · Physics 2022-07-14 Zongze Li , Wenbin Mao

In this paper we will address the problem of developing mathematical models for the numerical simulation of the human circulatory system. In particular, we will focus our attention on the problem of haemodynamics in large human arteries.

Dynamical Systems · Mathematics 2007-05-23 Alfio Quarteroni

We show that the recoils of the body caused by cardiac motion and blood circulation provide a noninvasive method capable to display the motions of the heart muscle and the propagation of the pulse wave along aorta and its branches. The…

Medical Physics · Physics 2007-05-23 J. Kriz , P. Seba

Numerical models are increasingly used for non-invasive diagnosis and treatment planning in coronary artery disease, where service-based technologies have proven successful in identifying hemodynamically significant and hence potentially…

Medical Physics · Physics 2020-05-01 Jongmin Seo , Casey Fleeter , Andrew M. Kahn , Alison L. Marsden , Daniele E. Schiavazzi

Three-dimensional cardiovascular fluid dynamics simulations typically require computation of several cardiac cycles before they reach a periodic solution, rendering them computationally expensive. Furthermore, there is currently no…

Computational Engineering, Finance, and Science · Computer Science 2021-06-28 Martin R. Pfaller , Jonathan Pham , Nathan M. Wilson , David W. Parker , Alison L. Marsden

We present a geometric surface parameterization algorithm and several visualization techniques adapted to the problem of understanding the 4D peristaltic-like motion of the outflow tract (OFT) in an embryonic chick heart. We illustrated the…

Graphics · Computer Science 2015-09-30 Ly Phan , Sandra Rugonyi , Cindy Grimm

We present a new computational model for the numerical simulation of blood flow in the human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian Eulerian formulation to account for the endocardium motion…

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