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Biological systems can rely on collective formation of a metachronal wave in an ensemble of oscillators for locomotion and for fluid transport. We consider one-dimensional chains of phase oscillators with nearest neighbor interactions,…

Biological Physics · Physics 2023-03-15 A. C. Quillen

Time-decaying perturbations of nonlinear oscillatory systems in the plane are considered. It is assumed that the unperturbed systems are non-isochronous and the perturbations oscillate with an asymptotically constant frequency. Resonance…

Dynamical Systems · Mathematics 2023-10-10 Oskar A. Sultanov

In human cells, estrogenic signals induce cyclical association and dissociation of specific proteins with the DNA in order to activate transcription of estrogen-responsive genes. These oscillations can be modeled by assuming a large number…

Cell Behavior · Quantitative Biology 2007-05-23 Vincent Lemaire , Chiu Fan Lee , Jinzhi Lei , Raphael Metivier , Leon Glass

Biological oscillations are periodic changes in various signaling processes crucial for the proper functioning of living organisms. These oscillations are modeled by ordinary differential equations, with coefficient variations leading to…

Machine Learning · Computer Science 2024-12-04 Heng Rao , Yu Gu , Jason Zipeng Zhang , Ge Yu , Yang Cao , Minghan Chen

We consider application of the multiple time delayed feedback for control of anharmonic (nonlinear) oscillators subject to noise. In contrast to the case of a single delay feedback, the multiple one exhibits resonances between feedback and…

Statistical Mechanics · Physics 2014-07-30 Denis S. Goldobin

Regulation of multiple reaction modules is quite common in molecular computation and deep learning networks construction through chemical reactions, as is always a headache for that sequential execution of modules goes against the…

Dynamical Systems · Mathematics 2022-11-08 Xiaopeng Shi , Chuanhou Gao , Denis Dochain

Oscillatory activities are widely observed in specific frequency bands of recorded field potentials in different brain regions, and play critical roles in processing neural information. Understanding the structure of these oscillatory…

Neurons and Cognition · Quantitative Biology 2015-07-23 Pengsheng Zheng

The conventional impedance profile of a neuron can identify the presence of resonance and other properties of the neuronal response to oscillatory inputs, such as nonlinear response amplifications, but it cannot distinguish other nonlinear…

Neurons and Cognition · Quantitative Biology 2019-10-24 Rodrigo F. O. Pena , Vinicius Lima , Renan O. Shimoura , Cesar C. Ceballos , Horacio G. Rotstein , Antonio C. Roque

We study a system of dynamical units, each of which shows excitable or oscillatory behavior, depending on the choice of parameters. When we couple these units with repressive bonds, we can control the duration of collective oscillations for…

Molecular Networks · Quantitative Biology 2014-02-06 Darka Labavic , Hildegard Meyer-Ortmanns

Networks of neural mass nodes with delayed interactions are increasingly being used as models for large-scale brain activity. To complement the growing number of computational studies of such networks, it is timely to develop new…

Dynamical Systems · Mathematics 2025-09-29 S Coombes , H G E Meijer

The dynamics of an ensemble of bistable elements under the influence of noise and with global time-delayed coupling is studied numerically by using a Langevin description and analytically by using 1) a Gaussian approximation and 2) a…

Statistical Mechanics · Physics 2009-11-10 Daniel Huber , Lev S. Tsimring

The transient response to a stimulus and subsequent recovery to a steady state are the fundamental characteristics of a living organism. Here we study the relaxation kinetics of autoregulatory gene networks based on the chemical master…

Molecular Networks · Quantitative Biology 2018-03-06 Chen Jia , Hong Qian , Min Chen , Michael Q. Zhang

Feedback circuits in biochemical networks which underly cellular signaling pathways are important elements in creating complex behavior. A specific aspect thereof is how stability of equilibrium points depends on model parameters. For…

Molecular Networks · Quantitative Biology 2007-11-20 Steffen Waldherr , Frank Allgower

The design of biological systems is hindered by uncertainty arising from both intrinsic stochasticity of biomolecular reactions and variability across laboratory or experimental conditions. In this work, we present a sequential framework to…

Machine Learning · Computer Science 2026-05-08 Michal Kobiela , Diego A. Oyarzún , Michael U. Gutmann

Inspired by the observation of a distributed time delay in the nonlinear response of an optical resonator, we investigate the effects of a similar delay on a noise-driven mechanical oscillator. For a delay time that is commensurate with the…

Optics · Physics 2022-02-16 K. J. H. Peters , S. R. K. Rodriguez

Periodic recurrence is a prominent behavioural of many biological phenomena, including cell cycle and circadian rhythms. Although deterministic models are commonly used to represent the dynamics of periodic phenomena, it is known that they…

Formal Languages and Automata Theory · Computer Science 2024-05-16 Paolo Ballarini , Mahmoud Bentriou , Paul-Henry Cournède

Phenotype-based screening has attracted much attention for identifying cell-active compounds. Transcriptional and proteomic profiles of cell population or single cells are informative phenotypic measures of cellular responses to…

Quantitative Methods · Quantitative Biology 2023-11-20 Wei Huang , Aichun Zhu , Hui Liu

Cells receive a wide variety of cellular and environmental signals, which must be processed combinatorially to generate specific and timely genetic responses. We present here a theoretical study on the combinatorial control and integration…

Soft Condensed Matter · Physics 2007-05-23 Nicolas E. Buchler , Ulrich Gerland , Terence Hwa

Living cells communicate information about physiological conditions by producing signaling molecules in a specific timed manner. Different conditions can result in the same total amount of a signaling molecule, differing only in the pattern…

Molecular Networks · Quantitative Biology 2018-10-09 Jackson O'Brien , Arvind Murugan

We consider a quantum space with rotationally invariant noncommutative algebra of coordinates and momenta. The algebra contains tensors of noncommutativity constructed involving additional coordinates and momenta. In the rotationally…

Quantum Physics · Physics 2019-03-05 Kh. P. Gnatenko