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Personalized medicine has become an important part of medicine, for instance predicting individual drug responses based on genomic information. However, many current statistical methods are not tailored to this task, because they overlook…

Applications · Statistics 2019-10-03 Shih-Ting Huang , Yannick Düren , Kristoffer H. Hellton , Johannes Lederer

Inference for high-dimensional logistic regression models using penalized methods has been a challenging research problem. As an illustration, a major difficulty is the significant bias of the Lasso estimator, which limits its direct…

Methodology · Statistics 2024-10-29 Yuming Zhang , Stéphane Guerrier , Runze Li

In recent years, there has been considerable theoretical development regarding variable selection consistency of penalized regression techniques, such as the lasso. However, there has been relatively little work on quantifying the…

Methodology · Statistics 2014-05-21 Arend Voorman , Ali Shojaie , Daniela Witten

Parameter estimation and the variable selection are two pioneer issues in regression analysis. While traditional variable selection methods require prior estimation of the model parameters, the penalized methods simultaneously carry on…

Methodology · Statistics 2021-09-01 Yetkin Tuaç , Olcay Arslan

We present a linear regression method for predictions on a small data set making use of a second possibly biased data set that may be much larger. Our method fits linear regressions to the two data sets while penalizing the difference…

Methodology · Statistics 2014-12-19 Aiyou Chen , Art B. Owen , Minghui Shi

In this work, we investigate the behavior of ridge regression in an overparameterized binary classification task. We assume examples are drawn from (anisotropic) class-conditional cluster distributions with opposing means and we allow for…

Machine Learning · Statistics 2025-03-12 Alexander Tsigler , Luiz F. O. Chamon , Spencer Frei , Peter L. Bartlett

Density regression characterizes the conditional density of the response variable given the covariates, and provides much more information than the commonly used conditional mean or quantile regression. However, it is often computationally…

Methodology · Statistics 2022-06-15 Yunlu Chen , Nan Zhang

In recent years, real-world external controls have grown in popularity as a tool to empower randomized placebo-controlled trials, particularly in rare diseases or cases where balanced randomization is unethical or impractical. However, as…

Methodology · Statistics 2024-11-14 Chenyin Gao , Shu Yang , Mingyang Shan , Wenyu Ye , Ilya Lipkovich , Douglas Faries

In many areas, practitioners need to analyze large datasets that challenge conventional single-machine computing. To scale up data analysis, distributed and parallel computing approaches are increasingly needed. Here we study a fundamental…

Statistics Theory · Mathematics 2020-06-04 Edgar Dobriban , Yue Sheng

Semiparametric regression offers a flexible framework for modeling non-linear relationships between a response and covariates. A prime example are generalized additive models where splines (say) are used to approximate non-linear functional…

Statistics Theory · Mathematics 2018-10-05 Francis K. C. Hui , Chong You , Han Lin Shang , Samuel Müller

A Two-Stage approach is described that literally "straighten outs" any potentially nonlinear relationship between a y-outcome variable and each of p = 2 or more potential x-predictor variables. The y-outcome is then predicted from all p of…

Methodology · Statistics 2023-10-03 Robert L. Obenchain

Linear regression is a fundamental and popular statistical method. There are various kinds of linear regression, such as mean regression and quantile regression. In this paper, we propose a new one called distribution regression, which…

Methodology · Statistics 2017-12-27 Xin Chen , Xuejun Ma , Wang Zhou

Multi-view data have been routinely collected in various fields of science and engineering. A general problem is to study the predictive association between multivariate responses and multi-view predictor sets, all of which can be of high…

Methodology · Statistics 2018-07-30 Gen Li , Xiaokang Liu , Kun Chen

We consider penalized regression models under a unified framework where the particular method is determined by the form of the penalty term. We propose a fully Bayesian approach that incorporates both sparse and dense settings and show how…

Methodology · Statistics 2019-07-25 Ding Xiang , Galin L. Jones

Parameter reduction can enable otherwise infeasible design and uncertainty studies with modern computational science models that contain several input parameters. In statistical regression, techniques for sufficient dimension reduction…

Numerical Analysis · Mathematics 2018-12-12 Andrew T. Glaws , Paul G. Constantine , R. Dennis Cook

Inference of instrumental variable regression models with many weak instruments attracts many attentions recently. To extend the classical Anderson-Rubin test to high-dimensional setting, many procedures adopt ridge-regularization. However,…

Methodology · Statistics 2025-04-30 Jiarong Ding , Xu Guo , Yanmei Shi , Yuxin Wang

In semi-supervised learning, the prevailing understanding suggests that observing additional unlabeled samples improves estimation accuracy for linear parameters only in the case of model misspecification. In this work, we challenge such a…

Methodology · Statistics 2025-09-03 Kai Chen , Yuqian Zhang

When developing risk prediction models, shrinkage methods are recommended, especially when the sample size is limited. Several earlier studies have shown that the shrinkage of model coefficients can reduce overfitting of the prediction…

Methodology · Statistics 2019-07-29 Ben Van Calster , Maarten van Smeden , Ewout W. Steyerberg

We develop a continuous-time penalized regression framework for the estimation of time-varying coefficients and variable selection when both the response and covariates are It\^o semimartingales with jumps. The coefficient paths are…

Econometrics · Economics 2026-04-28 Aleksey Kolokolov , Shifan Yu

Separation in logistic regression is a common problem causing failure of the iterative estimation process when finding maximum likelihood estimates. Firth's correction (FC) was proposed as a solution, providing estimates also in presence of…

Methodology · Statistics 2020-12-01 Hana Šinkovec , Angelika Geroldinger , Georg Heinze , Rok Blagus
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