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Genome-Wide Association Studies (GWAS) explain only a small fraction of heritability for most complex human phenotypes. Genomic heritability estimates the variance explained by the SNPs on the whole genome using mixed models and accounts…

There is growing interest in a hybrid control design in which a randomized controlled trial is augmented with an external control arm from a previous trial or real world data. Existing methods for analyzing hybrid control studies include…

Methodology · Statistics 2025-01-30 Zhiwei Zhang , Jialuo Liu , Wei Liu

In this study, we propose shrinkage methods based on {\it generalized ridge regression} (GRR) estimation which is suitable for both multicollinearity and high dimensional problems with small number of samples (large $p$, small $n$). Also,…

Statistics Theory · Mathematics 2020-03-04 Bahadır Yüzbaşı , Mohammad Arashi , S. Ejaz Ahmed

In this paper we present a general framework for estimating regression models subject to a user-defined level of fairness. We enforce fairness as a model selection step in which we choose the value of a ridge penalty to control the effect…

Machine Learning · Computer Science 2025-11-18 Marco Scutari , Francesca Panero , Manuel Proissl

We consider $L^2$-regularized linear (ridge) regression over a finite data sample $X$ with bounded covariance and linear prediction targets $y$ with additive isotropic noise of finite variance. We present an iterative procedure to compute…

Machine Learning · Computer Science 2026-05-28 Jack Timmermans , Sergio A. Alvarez

We examine the linear regression problem in a challenging high-dimensional setting with correlated predictors where the vector of coefficients can vary from sparse to dense. In this setting, we propose a combination of probabilistic…

Methodology · Statistics 2025-05-13 Roman Parzer , Peter Filzmoser , Laura Vana-Gür

This paper characterizes the conditional distribution properties of the finite sample ridge regression estimator and uses that result to evaluate total regression and generalization errors that incorporate the inaccuracies committed at the…

Machine Learning · Statistics 2016-05-31 Lyudmila Grigoryeva , Juan-Pablo Ortega

For high-dimensional linear regression models, we review and compare several estimators of variances $\tau^2$ and $\sigma^2$ of the random slopes and errors, respectively. These variances relate directly to ridge regression penalty…

Computation · Statistics 2019-02-08 Jurre R. Veerman , Gwenael G. R. Leday , Mark A. van de Wiel

Anomalies persist in the foundations of ridge regression as set forth in Hoerl and Kennard (1970) and subsequently. Conventional ridge estimators and their properties do not follow on constraining lengths of solution vectors using…

Statistics Theory · Mathematics 2011-03-30 D. R. Jensen , D. E. Ramirez

The least absolute shrinkage and selection operator (Lasso) is a popular method for high-dimensional statistics. However, it is known that the Lasso often has estimation bias and prediction error. To address such disadvantages, many…

Methodology · Statistics 2026-04-29 Guo Liu

In this study, we consider the problem of variable selection and estimation in high-dimensional linear regression models when the complete data are not accessible, but only certain marginal information or summary statistics are available.…

Applications · Statistics 2018-05-04 Jian Huang , Yuling Jiao , Jin Liu , Can Yang

We introduce an original method of multidimensional ridge penalization in functional local linear regressions. The nonparametric regression of functional data is extended from its multivariate counterpart, and is known to be sensitive to…

Methodology · Statistics 2021-09-20 Wentian Huang , David Ruppert

This study examines generalized cross-validation for the tuning parameter selection for ridge regression in high-dimensional misspecified linear models. The set of candidates for the tuning parameter includes not only positive values but…

Statistics Theory · Mathematics 2026-01-21 Akira Shinkyu

We study a ridge estimator for the high-dimensional two-way fixed effect regression model with a sparse bipartite network. We develop concentration inequalities showing that when the ridge parameters increase as the log of the network size,…

Econometrics · Economics 2026-01-08 Junnan He , Jean-Marc Robin

We consider the problem of model selection and estimation in sparse high dimensional linear regression models with strongly correlated variables. First, we study the theoretical properties of the dual Lasso solution, and we show that joint…

Applications · Statistics 2017-03-21 Niharika Gauraha

Regularized regression approaches such as the Lasso have been widely adopted for constructing sparse linear models in high-dimensional datasets. A complexity in fitting these models is the tuning of the parameters which control the level of…

Methodology · Statistics 2019-03-12 Ellis Patrick , Samuel Mueller

In this paper we introduce a new method for automatically selecting knots in spline regression. The approach consists in setting a large number of initial knots and fitting the spline regression through a penalized likelihood procedure…

Applications · Statistics 2025-05-20 Vivien Goepp , Olivier Bouaziz , Grégory Nuel

Regularized regression techniques for linear regression have been created the last few ten years to reduce the flaws of ordinary least squares regression with regard to prediction accuracy. In this paper, new methods for using regularized…

Machine Learning · Computer Science 2013-12-13 Doreswamy , Chanabasayya . M. Vastrad

Cross-correlation techniques provide a promising avenue for calibrating photometric redshifts and determining redshift distributions using spectroscopy which is systematically incomplete (e.g., current deep spectroscopic surveys fail to…

Instrumentation and Methods for Astrophysics · Physics 2012-01-20 Daniel J. Matthews , Jeffrey A. Newman

Genetic variants identified to date by genome-wide association studies only explain a small fraction of total heritability. Gene-by-gene interaction is one important potential source of unexplained heritability. In the first part of this…

Methodology · Statistics 2016-05-10 Chen Lu
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