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A mesoscopic coarse-grain model for computationally-efficient simulations of biomembranes is presented. It combines molecular dynamics simulations for the lipids, modeled as elastic chains of beads, with multiparticle collision dynamics for…

Soft Condensed Matter · Physics 2015-06-04 Mu-Jie Huang , Raymond Kapral , Alexander S. Mikhailov , Hsuan-Yi Chen

A simple kinetic model of a two-component deformable and reactive bilayer is presented. The two differently shaped components are interconverted by a nonequilibrium reaction, and a phenomenological coupling between local composition and…

Soft Condensed Matter · Physics 2009-11-11 Ramon Reigada , Javier Buceta , Katja Lindenberg

We develop a theoretical framework for understanding dynamic morphologies and stability of droplet interface bilayers (DIBs), accounting for lipid kinetics in the monolayers and bilayer, and droplet evaporation due to imbalance between…

Soft Condensed Matter · Physics 2018-06-13 Benjamin Guiselin , Jack O. Law , Buddhapriya Chakrabarti , Halim Kusumaatmaja

We propose a model describing liquid-solid phase coexistence in mixed lipid membranes by including explicitly the occurrence of a rippled phase. For a single component membrane, we employ a previous model in which the membrane thickness is…

Soft Condensed Matter · Physics 2012-01-31 N. Shimokawa , S. Komura , D. Andelman

Liposomes that achieve a heterogeneous and spatially organized surface through phase separation have been recognized to be a promising platform for delivery purposes. However, their design and optimization through experimentation can be…

Soft Condensed Matter · Physics 2021-11-05 Y. Wang , Y. Palzhanov , A. Quaini , M. Olshanskii , S. Majd

We study the role of fluctuations on the thermodynamic glassy properties of plaquette spin models, more specifically on the transition involving an overlap order parameter in the presence of an attractive coupling between different replicas…

Statistical Mechanics · Physics 2018-04-20 Giulio Biroli , Charlotte Rulquin , Gilles Tarjus , Marco Tarzia

By evaporating a drop of lipid dispersion we generate the myelin morphology often seen in dissolving surfactant powders. We explain these puzzling nonequilibrium structures using a geometric argument: The bilayer repeat spacing increases…

Soft Condensed Matter · Physics 2007-05-23 Jung-Ren Huang , Ling-Nan Zou , Thomas A. Witten

We study the effects of chiral constituent molecules on the macroscopic shapes attained by lipid bilayer membranes. Such fluid membranes are beautiful examples of statistical ensembles of random shapes, sometimes coupled to in-plane order.…

Condensed Matter · Physics 2008-02-03 P. Nelson , T. Powers

Phase transformations can be difficult to characterize at the microscopic level due to the inability to directly observe individual atomic motions. Model colloidal systems, by contrast, permit the direct observation of individual particle…

Soft Condensed Matter · Physics 2015-04-21 Ye Yang , Lin Fu , Catherine Marcoux , Joshua E. S. Socolar , Patrick Charbonneau , Benjamin B. Yellen

We analyze both the static and dynamic fluctuation spectrum of the red-blood cell in a unified manner, using a simple model of the composite membrane. In this model, the two-dimensional spectrin network that forms the cytoskeleton is…

Soft Condensed Matter · Physics 2007-05-23 N. Gov , A. G. Zilman , S. Safran

We present a model for the efficient simulation of generic bilayer membranes. Individual lipids are represented by one head- and two tail-beads. By means of simple pair potentials these robustly self-assemble to a fluid bilayer state over a…

Soft Condensed Matter · Physics 2009-11-11 Ira R. Cooke , Kurt Kremer , Markus Deserno

Understanding interactions between membranes requires measurements on well-controlled systems close to natural conditions, in which fluctuations play an important role. We have determined, by grazing incidence X-ray scattering, the…

Multi-component membranes such as ternary mixtures of lipids and cholesterol can exhibit coexistence regions between two liquid phases. When such membranes adhere to a corrugated substrate, the phase separation process strongly depends on…

Soft Condensed Matter · Physics 2009-11-13 Bartosz Rozycki , Thomas R. Weikl , Reinhard Lipowsky

We present a simple and highly adaptable method for simulating coarse-grained lipid membranes without explicit solvent. Lipids are represented by one head-bead and two tail-beads, with the interaction between tails being of key importance…

Soft Condensed Matter · Physics 2009-11-11 I. R. Cooke , M. Deserno

We discuss the dynamics of a bilayer membrane with partial slip boundary conditions between the monolayers and the bulk fluid. Using Onsager's variational principle to account for the associated dissipations, we derive the coupled dynamic…

Soft Condensed Matter · Physics 2018-07-18 Kento Yasuda , Ryuichi Okamoto , Shigeyuki Komura , Jean-Baptiste Fournier

The presence of thermal gradients in alloys often leads to non-uniformity in concentration profiles, which can induce the thermomigration of microstructural features such as precipitates. To investigate such microstructural changes, we…

Materials Science · Physics 2024-06-04 Sandip Guin , Soumya Bandyopadhyay , Saswata Bhattacharyya , Rajdip Mukherjee

Cholesterol is known to modulate the structure and function of biological membranes. In this study, we use self-consistent field theory (SCFT) to investigate phospholipid/cholesterol bilayer membranes modeled with two types of diblock…

Soft Condensed Matter · Physics 2025-05-21 Xiaoyuan Wang , Fredric S. Cohen , Shixin Xu , Yongqiang Cai

The physical properties of blends of distinct homopolymers, cross-linked beyond the gelation point, are addressed via a Landau approach involving a pair of coupled order-parameter fields: one describing vulcanisation, the other describing…

Soft Condensed Matter · Physics 2009-11-10 Christian Wald , Annette Zippelius , Paul M. Goldbart

Facilitated spin models on random graphs provide an ideal microscopic realization of the mode-coupling theory of supercooled liquids: they undergo a purely dynamic glass transition with no thermodynamic singularity. In this paper we study…

Statistical Mechanics · Physics 2015-06-11 Silvio Franz , Mauro Sellitto

Isolated domains in lipid monolayers exhibit shape transitions as a consequence of the competing effects of line tension and long-range dipolar interactions. Nontrivial integrals ultimately arise in instability analysis calculations of…

Soft Condensed Matter · Physics 2007-05-23 Jose A. Miranda