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The reaction-diffusion models have been extensively applied to explain the mechanism of pattern formations in early embryogenesis based on geometrically confined microtissues consisting of human pluripotent stem cells. Recently, mechanical…

Biological Physics · Physics 2022-11-22 Tiankai Zhao , Hongyan Yuan

We study the formation of spot patterns seen in a variety of bacterial species when the bacteria are subjected to oxidative stress due to hazardous byproducts of respiration. Our approach consists of coupling the cell density field to a…

This paper introduces a reaction-diffusion-chemotaxis model for bacterial aggregation patterns on the surface of thin agar plates. It is based on the non-linear degenerate cross diffusion model proposed by Kawasaki et al. (J. of Theor.…

Cell Behavior · Quantitative Biology 2013-01-23 J. Francisco Leyva , Carlos Malaga , Ramon G. Plaza

Biomolecular condensates form on timescales of seconds in cells upon environmental or compositional changes. Condensate formation is thus argued to act as a mechanism for sensing such changes and quickly initiating downstream processes,…

Subcellular Processes · Quantitative Biology 2025-12-09 Henry Alston , Mason Rouches , Arvind Murugan , Aleksandra M. Walczak , Thierry Mora

In the domain of molecular communication (MC), information is conveyed through the characteristics of molecules transmitted between the transmitter and the receiver bionanosensors via propagation. The constrained size of the transmitter…

Information Theory · Computer Science 2025-08-07 Dongliang Jing , Linjuan Li , Lin Lin , Andrew W. Eckford

In this paper, a diffusion-based molecular communication channel is modeled in presence of a probabilistic absorber. The probabilistic absorber is an absorber which absorbs molecules upon collision with probability q. With random walk…

Emerging Technologies · Computer Science 2019-09-19 S Salehi , NS Moayedian , E Alarcón

In this paper, we derive a new chemotaxis model with degenerate diffusion and density-dependent chemotactic sensitivity, and we provide a more realistic description of cell migration process for its early and late stages. Different from the…

Analysis of PDEs · Mathematics 2023-07-19 Tianyuan Xu , Shanming Ji , Chunhua Jin , Ming Mei , Jingxue Yin

Bacterial quorum sensing can be engineered with a view to the design of biotechnological applications based on their intrinsic role as a means of communication. We propose the creation of a positive feedback loop that will promote the…

Cell Behavior · Quantitative Biology 2021-04-15 Daniel P. Martins , Huong Q. -O'Reilly , Lee Coffey , Paul D. Cotter , Sasitharan Balasubramaniam

A network of nanomachines (NMs) can be used to build a target detection system for a variety of promising applications. They have the potential to detect toxic chemicals, infectious bacteria, and biomarkers of dangerous diseases such as…

Information Theory · Computer Science 2024-01-10 Nithin V. Sabu , Abhishek K. Gupta

In the end of the second decade of 20th century, Warburg showed how cancer cells present a fermentative respiration process, related to a metabolic injury. Here, we develop an analysis of the cell process based on its heat outflow, in order…

Cell Behavior · Quantitative Biology 2021-07-27 Umberto Lucia , Giulia Grisolia

Molecular communications (MC), where molecules are used to encode, transmit, and receive information, is a promising means of enabling the coordination of nanoscale devices. The paradigm has been extensively studied from various aspects,…

Emerging Technologies · Computer Science 2016-03-29 Murat Kuscu , Ozgur B. Akan

Structured illumination microscopy (SIM) has attained high spatiotemporal delineation of subcellular architecture, yet offers limited insight into chemical composition. We develop Chem-SIM, a structured-illumination fluorescence detected…

The microalga Chlamydomonas Reinhardtii (CR) is used here as a model system to study the effect of complex environments on the swimming of micro-organisms. Its motion can be modelled by a run and tumble mechanism so that it describes a…

Soft Condensed Matter · Physics 2019-03-27 Marvin Brun-Cosme-Bruny , Eric Bertin , Benoît Coasne , Philippe Peyla , Salima Rafaï

In the course of various biological processes, specific DNA-binding proteins must find a particular target sequence/protein or a damaged site on the DNA efficiently. DNA-binding proteins perform this task based on diffusion. Yet,…

Biological Physics · Physics 2021-02-24 Seongyu Park , O-chul Lee , Xavier Durang , Jae-Hyung Jeon

Cellular metabolic rate is a good indicator of the physiological state of cells and its changes, which can be measured by total heat flux accompanying metabolism. Chip calorimeters can provide label-free and high throughput measurements of…

Biological Physics · Physics 2019-03-13 Jihye Kim , Sumin Seo , Jonghyun Kim , Sungmin Nam , Wonhee Lee

Navigation of microorganisms is controlled by internal processes ultimately sensitive to mechanical or chemical signaling encountered along the path. In many natural environments, such as porous soils or physiological ducts, motile species…

Motivated by observations of the dynamics of {\it Myxococcus xanthus}, we present a self-interacting random walk model that describes the competition between chemokinesis and chemotaxis. Cells are constrained to move in one dimension, but…

Statistical Mechanics · Physics 2016-08-31 Maria R. D'Orsogna , Marc Suchard , Tom Chou

Mycelium, a natural and sustainable material, possesses unique electrical, mechanical, and biological properties that make it a promising candidate for biosensor applications. These properties include its ability to conduct electrical…

Applied Physics · Physics 2026-01-14 Bao Zhao , Sophia Ganzeboom , Marcus Haywood-Alexander , Eleni Chatzi , Vasilis Dertimanis

Autologous chemotaxis, in which cells secrete and detect molecules to determine the direction of fluid flow, is thwarted at high cell density because molecules from other cells interfere with a given cell's signal. Using a minimal model of…

Biological Physics · Physics 2022-09-14 Michael Vennettilli , Louis Gonzalez , Nicholas Hilgert , Andrew Mugler

Biological sensory systems generally operate out of equilibrium, which often leads to their improved performance. Here, we study the sensitivity of ligand concentration for a general receptor model, which is generally in the non-equilibrium…

Biological Physics · Physics 2017-06-27 Takashi Okada