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We study the emergence of cell differentiation under the assumption of the existence of a given number of tradeoffs between genes encoding different functions. In the model the viability of colonies is determined by the capability of their…

Populations and Evolution · Quantitative Biology 2017-06-06 André Amado , Paulo R. A. Campos

We explore and quantify the physical and biochemical mechanisms that may be relevant in the regulation of translation. After elongation and detachment from the 3' termination site of mRNA, parts of the ribosome machinery can diffuse back to…

Soft Condensed Matter · Physics 2009-11-10 Tom Chou

Cellular renewing active matter - assemblies of proliferating and apoptotic cells - underlies tissue homeostasis, morphogenesis, and clonal competition. Previous work in one-dimensional periodic systems identified a fitness advantage…

Soft Condensed Matter · Physics 2025-12-02 Patrick Zimmer , Philip Bittihn , Yoav G. Pollack

A central model in theoretical ecology considers the competition of a range of species for a broad spectrum of resources. Recent studies have shown that essentially two different outcomes are possible. Either the species surviving…

Populations and Evolution · Quantitative Biology 2010-04-05 Simone Pigolotti , Cristobal Lopez , Emilio Hernandez-Garcia , Ken Haste Andersen

We revisit a totally asymmetric simple exclusion process (TASEP) with open boundaries and a global constraint on the total number of particles [Adams, et. al. 2008 J. Stat. Mech. P06009]. In this model, the entry rate of particles into the…

Statistical Mechanics · Physics 2009-08-30 L. Jonathan Cook , R. K. P. Zia

Understanding to what extent stem cell potential is a cell-intrinsic property, or an emergent behavior coming from global tissue dynamics and geometry, is a key outstanding question of systems and stem cell biology. Here, we propose a…

A system consisting of two parallel coupled channels where particles in one of them follow the rules of totally asymmetric exclusion processes (TASEP) and in another one move as in symmetric simple exclusion processes (SSEP) is investigated…

Statistical Mechanics · Physics 2009-11-13 K. Tsekouras , A. B. Kolomeisky

We study mixing times of the symmetric and asymmetric simple exclusion process on the segment where particles are allowed to enter and exit at the endpoints. We consider different regimes depending on the entering and exiting rates as well…

Probability · Mathematics 2022-05-03 Nina Gantert , Evita Nestoridi , Dominik Schmid

The totally asymmetric simple exclusion process (TASEP) is a basic model of statistical mechanics that has found numerous applications. We consider the case of TASEP with a finite chain where particles may enter from the left and leave to…

Dynamical Systems · Mathematics 2020-06-23 Lars Grüne , Thomas Kriecherbauer , Michael Margaliot

Ecosystems are commonly organized into trophic levels -- organisms that occupy the same level in a food chain (e.g., plants, herbivores, carnivores). A fundamental question in theoretical ecology is how the interplay between trophic…

Populations and Evolution · Quantitative Biology 2023-03-07 Zhijie Feng , Robert Marsland , Jason W. Rocks , Pankaj Mehta

In the process of translation, ribosomes read the genetic code on an mRNA and assemble the corresponding polypeptide chain. The ribosomes perform discrete directed motion which is well modeled by a totally asymmetric simple exclusion…

Biomolecules · Quantitative Biology 2007-08-02 J. J. Dong , B. Schmittmann , R. K. P. Zia

We study how increasing competition, by making prizes more unequal, affects effort in contests. In a finite type-space environment, we characterize the equilibrium, analyze the effect of competition under linear costs, and identify…

Theoretical Economics · Economics 2025-02-13 Andrzej Baranski , Sumit Goel

The capacity of distant parties to send signals to one another is a fundamental requirement in many information-processing tasks. Such ability is determined by the causal structure connecting the parties, and more generally, by the…

Quantum Physics · Physics 2022-08-31 Simon Milz , Jessica Bavaresco , Giulio Chiribella

We study the effects of randomness on competitions based on an elementary random process in which there is a finite probability that a weaker team upsets a stronger team. We apply this model to sports leagues and sports tournaments, and…

Physics and Society · Physics 2013-04-02 E. Ben-Naim , N. W. Hengartner , S. Redner , F. Vazquez

The evolution of multicellularity was a major transition in the history of life on earth. Conditions under which multicellularity is favored have been studied theoretically and experimentally. But since the construction of a multicellular…

Populations and Evolution · Quantitative Biology 2018-03-19 Jason Olejarz , Kamran Kaveh , Carl Veller , Martin A. Nowak

In this paper we consider a model of particles jumping on a row of cells, called in physics the one dimensional totally asymmetric exclusion process (TASEP). More precisely we deal with the TASEP with open or periodic boundary conditions…

Combinatorics · Mathematics 2007-05-23 Enrica Duchi , Gilles Schaeffer

It is known that the competitive exclusion principle holds for a large kind of models involving several species competing for a single resource in an homogeneous environment. Various works indicate that the coexistence is possible in an…

Analysis of PDEs · Mathematics 2014-07-22 François Castella , Sten Madec , Yvan Lagadeuc

All cells must keep time to consistently perform vital biological functions. To that end, the coupling and interrelatedness of diverse subsecond events in the complex cellular environment, such as protein folding or translation rates,…

Subcellular Processes · Quantitative Biology 2012-10-02 Sepehr Ehsani

We study the totally asymmetric simple exclusion process (TASEP) on $\mathbb{Z}$ with step initial condition, in which all particles have distinct types. Our main object of interest is the type of the rightmost particle -- the leader -- at…

Probability · Mathematics 2026-01-30 Alexei Borodin , Alexey Bufetov

Consider a population of agents who repeatedly compete for awards, as in the case of researchers annually applying for grants. Noise in the selection process may encourage entry of low quality proposals, forcing the principal to commit…

Theoretical Economics · Economics 2024-11-28 Yaron Azrieli
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