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We measure different contributions to entropy production in a living functional epithelial tissue. We do this by extracting the functional dynamics of development while at the same time quantifying fluctuations. Using the translucent…

Soft Condensed Matter · Physics 2023-01-25 Mark Olenik , Jake Turley , Stephen Cross , Helen Weavers , Paul Martin , Isaac Chenchiah , Tanniemola Liverpool

Intracellular protein patterns regulate a variety of vital cellular processes such as cell division and motility, which often involve dynamic changes of cell shape. These changes in cell shape may in turn affect the dynamics of…

Pattern Formation and Solitons · Physics 2023-07-19 Laeschkir Würthner , Andriy Goychuk , Erwin Frey

Cellular uptake of nanoplastics is instrumental in their environmental accumulation and transfer to humans through the food chain. Despite extensive studies using spherical plastic nanoparticles, the influence of the morphological…

Soft Condensed Matter · Physics 2023-08-29 Xin Yong , Ke Du

Biological membranes constitute boundaries of cells and cell organelles. Physico-chemical mechanisms at the atomic scale are dictated by protein-lipid interaction strength, lipid composition, lipid distribution in the vicinity of the…

Biological Physics · Physics 2015-10-19 N. Ramakrishnan , P. B. Sunil Kumar , Ravi Radhakrishnan

Quantitative studies of cell metabolism are often based on large chemical reaction network models. A steady state approach is suited to analyze phenomena on the timescale of cell growth and circumvents the problem of incomplete experimental…

Molecular Networks · Quantitative Biology 2019-02-20 A. De Martino , D. De Martino , E. Marinari

Accurate physical modeling with 3D-printing techniques could lead to new approaches to study structure and dynamics of biological systems complementing computational methods. Computational biology has become an important part of research…

Other Computer Science · Computer Science 2015-07-14 Promita Chakraborty

We discuss the Lattice Boltzmann-Particle Dynamics (LBPD) multiscale paradigm for the simulation of complex states of flowing matter at the interface between Physics, Chemistry and Biology. In particular, we describe current large-scale…

Computational Physics · Physics 2019-06-05 Massimo Bernaschi , Simone Melchionna , Sauro Succi

It is increasingly being realized that liquid-crystalline features can play an important role in the properties and dynamics of cell monolayers. Here, we present a cell-based model of cell layers, based on the phase-field formulation, that…

Soft Condensed Matter · Physics 2022-04-28 Aleksandra Ardaševa , Romain Mueller , Amin Doostmohammadi

Embryonic development leads to the reproducible and ordered appearance of complexity from egg to adult. The successive differentiation of different cell types, that elaborates this complexity, result from the activity of gene networks and…

Quantitative Methods · Quantitative Biology 2022-05-11 David A. Rand , Archishman Raju , Meritxell Saez , Francis Corson , Eric D. Siggia

Nanoscale biosystems are widely used in numerous medical applications. The approaches for structure and function of the nanomachines that are available in the cell (natural nanomachines) are discussed. Molecular simulation studies have been…

Biological Physics · Physics 2016-09-08 Babu A Manjasetty , T. R. Gopalakrishnan Nair , Y. S. Ramaswamy

For many materials, a precise knowledge of their dispersion spectra is insufficient to predict their ordered phases and physical responses. Instead, these materials are classified by the geometrical and topological properties of their…

Materials Science · Physics 2021-06-16 Qiong Ma , Adolfo G. Grushin , Kenneth S. Burch

Glorified dimensional analysis is used to derive scaling rules for internal and external magnetic field strengths and various time scales. Naive dimensional analysis is inconclusive because of multiple time scales, but physical arguments…

Solar and Stellar Astrophysics · Physics 2016-03-31 Bertrand Barrois

Intracellular protein patterns regulate many vital cellular functions, such as the processing of spatiotemporal information or the control of shape deformations. To do so, pattern-forming systems can be sensitive to the cell geometry by…

Biological Physics · Physics 2024-05-15 Tom Burkart , Benedikt J. Müller , Erwin Frey

Mathematical modelling is a cornerstone of computational biology. While mechanistic models might describe the interactions of interest of a system, they are often difficult to study. On the other hand, abstract models might capture key…

Dynamical Systems · Mathematics 2025-05-01 Lucas Jesus Morales-Moya

One of the important challenges facing high resolution molecular dynamics calculations is to reproduce biological functions that occur in the macroscopic world and involve macroscopic variables. Some of these functions can be well described…

Biomolecules · Quantitative Biology 2008-02-18 Bob Eisenberg

The remarkable range of biological forms in and around us, such as the undulating shape of a leaf or flower in the garden, the coils in our gut, or the folds in our brain, raise a number of questions at the interface of biology, physics and…

General Mathematics · Mathematics 2021-05-13 Marta Lewicka , L. Mahadevan

Can the spatial distance between two identical particles be explained in terms of the extent that one can be distinguished from the other? Is the geometry of space a macroscopic manifestation of an underlying microscopic statistical…

General Relativity and Quantum Cosmology · Physics 2015-06-25 Ariel Caticha

Understanding the mechanisms of interactions within cells, tissues, and organisms is crucial to driving developments across biology and medicine. Mathematical modeling is an essential tool for simulating biological systems and revealing…

Molecular Networks · Quantitative Biology 2024-08-13 Lingxia Qiao , Ali Khalilimeybodi , Nathaniel J Linden-Santangeli , Padmini Rangamani

The importance of molecular-scale forces in sculpting biological form and function has been acknowledged for more than a century. Accounting for forces in biology is a problem that lies at the intersection of soft condensed matter physics,…

Soft Condensed Matter · Physics 2025-12-10 K. Vijay Kumar , Mandar M. Inamdar , Pramod A. Pullarkat , Gautam I. Menon

Nanoparticles with different surface morphologies that straddle the interface between two immiscible liquids are studied via molecular dynamics simulations. The methodology employed allows us to compute the interfacial free energy at…

Soft Condensed Matter · Physics 2016-04-27 Sepideh Razavi , Ilona Kretzschmar , Joel Koplik , Carlos E. Colosqui