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Understanding principles of neurolocomotion requires the synthesis of neural activity, sensory feedback, and biomechanics. The nematode \textit{C. elegans} is an ideal model organism for studying locomotion in an integrated neuromechanical…

Neurons and Cognition · Quantitative Biology 2021-06-08 Carter L. Johnson , Timothy J. Lewis , Robert D. Guy

The nematode Caenorhabditis elegans (C. elegans) is used as a model organism to better understand developmental biology and neurobiology. C. elegans features an invariant cell lineage, which has been catalogued and observed using…

Computer Vision and Pattern Recognition · Computer Science 2022-08-03 Andrew Lauziere , Ryan Christensen , Hari Shroff

Despite the relative simplicity of C. elegans, its locomotion machinery is not yet well understood. We focus on the generation of dorsoventral body bends. While central pattern generators are commonly involved in animal locomotion, their…

Neurons and Cognition · Quantitative Biology 2017-11-08 Erick Olivares , Eduardo J. Izquierdo , Randall D. Beer

Gastrulation, namely cell internalization, is a significant milestone during the development of metazoans from worm to human, which generates multiple embryonic layers with distinct cell fates and spatial organizations. Although many…

Cell Behavior · Quantitative Biology 2022-01-17 Jiao Miao , Guoye Guan , Chao Tang

The motility of the worm nematode \textit{Caenorhabditis elegans} is investigated in shallow, wet granular media as a function of particle size dispersity and area density ($\phi$). Surprisingly, we find that the nematode's propulsion speed…

Biological Physics · Physics 2012-03-06 G. Juarez , K. Lu , J. Sznitman , P. E. Arratia

Undulatory locomotion, as seen in the nematode \emph{Caenorhabditis elegans}, is a common swimming gait of organisms in the low Reynolds number regime, where viscous forces are dominant. While the nematode's motility is expected to be a…

Biological Physics · Physics 2017-08-02 Josue Sznitman , Prashant K. Purohit , Predrag Krajacic , Todd Lamitina , Paulo E. Arratia

Self-propelling organisms locomote via generation of patterns of self-deformation. Despite the diversity of body plans, internal actuation schemes and environments in limbless vertebrates and invertebrates, such organisms often use similar…

Computational approaches which emulate in-vivo nervous system are needed to investigate mechanisms of the brain to orchestrate behavior. Such approaches must integrate a series of biophysical models encompassing the nervous system, muscles,…

Quantitative Methods · Quantitative Biology 2025-06-05 Jimin Kim , Jeremy T. Florman , Julia A. Santos , Mark J. Alkema , Eli Shlizerman

The video showcases how C. elegans worms respond to DC and AC electrical stimulations. Gabel et al (2007) demonstrated that in the presence of DC and low frequency AC fields, worms of stage L2 and larger propel themselves towards the…

Fluid Dynamics · Physics 2015-05-20 Han-Sheng Chuang , David Raizen , Nooreen Dabbish , Haim Bau

The small (1 mm) nematode $\textit{Caenorhabditis elegans}$ (Corsi [1], wormbook.org) has become widely used as a model organism; in particular, the $\textit{C. elegans}$ connectome has been completely mapped, and $\textit{C. elegans}$…

Biological Physics · Physics 2021-10-22 Anshul Singhvi , Harold M. Hastings , Jenny Magnes , Susannah G. Zhang

A central problem of neuroscience involves uncovering the principles governing the organization of nervous systems which ensure robustness in brain development. The nematode Caenorhabditis elegans provides us with a model organism for…

Neurons and Cognition · Quantitative Biology 2020-07-01 Anand Pathak , Nivedita Chatterjee , Sitabhra Sinha

How do we capture the breadth of behavior in animal movement, from rapid body twitches to aging? Using high-resolution videos of the nematode worm $C. elegans$, we show that a single dynamics connects posture-scale fluctuations with…

Biological Physics · Physics 2024-09-02 Antonio C. Costa , Tosif Ahamed , David Jordan , Greg J. Stephens

The 1mm roundworm C. elegans is a model organism used in many sub-areas of biology to investigate different types of biological processes. In order to complement the n-vivo analysis with computer-based investigations, several methods have…

Quantitative Methods · Quantitative Biology 2025-10-02 Nemanja Antonic , Monika Scholz , Aymeric Vellinger , Euphrasie Ramahefarivo , Elio Tuci

The swimming behaviour of microorganisms can be strongly influenced by the rheology of their fluid environment. In this manuscript, we experimentally investigate the effects of shear-thinning viscosity on the swimming behaviour of an…

Fluid Dynamics · Physics 2015-06-22 David A. Gagnon , Nathan C. Keim , Paulo E. Arratia

To establish the relationship between locomotory behavior and dynamics of neural circuits in the nematode C. elegans we combined molecular and theoretical approaches. In particular, we quantitatively analyzed the motion of C. elegans with…

Neurons and Cognition · Quantitative Biology 2008-06-10 Jan Karbowski , Gary Schindelman , Chris J. Cronin , Adeline Seah , Paul W. Sternberg

Nematodes have evolved to swim in highly viscous environments. Artificial mechanisms that mimic the locomotory functions of nematodes can be efficient viscous pumps. We experimentally simulate the motion of the head segment of…

Fluid Dynamics · Physics 2019-02-07 Ahmad Zareei , Mir Abbas Jalali , Mohsen Saadat , Peter Grenfell , Mohammad-Reza Alam

C. elegans is commonly used in neuroscience for behaviour analysis because of it's compact nervous system with well-described connectivity. Localizing the animal and distinguishing between its head and tail are important tasks to track the…

Computer Vision and Pattern Recognition · Computer Science 2020-01-14 Mansi Ranjit Mane , Aniket Anand Deshmukh , Adam J. Iliff

An organism's ability to move freely is a fundamental behaviour in the animal kingdom. To understand animal locomotion requires a characterisation of the material properties, as well as the biomechanics and physiology. We present a…

Biological Physics · Physics 2017-02-17 Netta Cohen , Thomas Ranner

The brain is one of the most studied and highly complex systems in the biological world. It is the information center behind all vertebrate and most invertebrate life, and thus has become a major focus in current research. While many of…

Neurons and Cognition · Quantitative Biology 2015-03-19 Daniel J. Kelleher , Tyler M. Reese , Dylan T. Yott , Antoni Brzoska

A quantitative understanding of organism-level behavior requires predictive models that can capture the richness of behavioral phenotypes, yet are simple enough to connect with underlying mechanistic processes. Here we investigate the…

Neurons and Cognition · Quantitative Biology 2019-03-26 Stephen J. Helms , W. Mathijs Rozemuller , Antonio Carlos Costa , Leon Avery , Greg J. Stephens , Thomas S. Shimizu