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The question of the onset of the homochirality on prebiotic Earth still remains a fundamental question in the quest for the origin of life. Recent works in this field introduce the concept of recycling, rather than the traditional open-flow…

Molecular Networks · Quantitative Biology 2011-05-23 Raphael Plasson

A recently proposed model of non-autocatalytic reactions in dipeptide reactions leading to spontaneous symmetry breaking and homochirality is examined. The model is governed by activation, polymerization, epimerization and depolymerization…

Biomolecules · Quantitative Biology 2007-11-01 Axel Brandenburg , Harry J. Lehto , Kirsi M. Lehto

The stability and conservation properties of a recently proposed polymerization model are studied. The achiral (racemic) solution is linearly unstable once the relevant control parameter (here the fidelity of the catalyst) exceeds a…

Biomolecules · Quantitative Biology 2007-05-23 A. Brandenburg , A. C. Andersen , S. Höfner , M. Nilsson

Life is homochiral and homochirality is a fundamental feature of living systems on Earth. While the exact mechanism that led to homochirality is still not fully understood, any realistic scenario on the origins of life needs to address the…

We propose a model for chiral polymerisation and investigate its symmetric and asymmetric solutions. The model has a source species which decays into left- and right-handed types of monomer, each of which can polymerise to form homochiral…

Biological Physics · Physics 2009-11-10 Jonathan AD Wattis , Peter V. Coveney

We explore the interplay between tunneling process and chiral interactions in the discrimination of chiral states for an ensemble of molecules in a biological environment. Each molecule is described by an asymmetric double-well potential…

Biomolecules · Quantitative Biology 2017-04-28 Arash Tirandaz , Farhad Taher Ghahramani , Afshin Shafiee

To study the establishment of homochirality observed in the crystal growth experiment of chiral molecules from a solution under grinding, we extend the lattice gas model of crystal growth as follows. A lattice site can be occupied by a…

Statistical Mechanics · Physics 2009-11-13 Yukio Saito , Hiroyuki Hyuga

Chirality is ubiquitous in nature and fundamental in science, from particle physics to metamaterials.The most established technique of chiral discrimination - photoabsorption circular dichroism - relies on the magnetic properties of a…

Diffusion effect on chirality selection in a two-dimensional reaction-diffusion model is studied by the Monte Carlo simulation. The model consists of achiral reactants A which turn into either of the chiral products, R or S, in a solvent of…

Statistical Mechanics · Physics 2007-07-20 Ryo Shibata , Yukio Saito , Hiroyuki Hyuga

Molecular chirality is critical to biochemical function, but it is unknown when chiral selectivity first became important in the evolutionary transition from geochemistry to biochemistry during the emergence of life. Here, we identify key…

Molecular Networks · Quantitative Biology 2025-05-05 John F. Malloy , Camerian Millsaps , Kamesh Narasimhan , Louie Slocombe , Cole Mathis , Leroy Cronin , Sara Imari Walker

The homochirality of biomolecules remains one of the outstanding puzzles concerning the beginning of life. Chiral amplification of a randomly perturbed racemic mixture of chiral molecules is a well-accepted prerequisite for all routes to…

Chemical Physics · Physics 2022-10-12 Uri Hananel , Assaf Ben-Moshe , Haim Diamant , Gil Markovich

Chirality is a feature of many biological systems and much research has been focused on understanding the origin and implications of this property. Famously, sugars and amino acids found in nature are homochiral, i.e., chiral symmetry is…

Cell Behavior · Quantitative Biology 2023-07-28 Ludwig A. Hoffmann , Luca Giomi

Chirality is probably the most mysterious among all symmetry transformations. Very readily broken in biological systems, it is practically absent in naturally occurring inorganic materials and is very challenging to create artificially.…

Most animal body plans have some degree of left-right asymmetry. This chirality at the tissue and organ level is often assumed to originate from the intrinsic handedness of biological molecules. How this handedness might be transferred from…

Tissues and Organs · Quantitative Biology 2017-08-30 Jeremy Hadidjojo , David K. Lubensky

The phase structure of a homopolymer chain is investigated in terms of a universal theoretical model, designed to describe the infrared limit of slow spatial variations. The effects of chirality are studied and compared with the influence…

Soft Condensed Matter · Physics 2015-12-25 A. Sinelnikova , A. J. Niemi , M. Ulybyshev

Living organisms exhibit consistent homochirality. It is argued that the specific, binary choice made is not an accident but is a consequence of parity violation in the weak interaction expressed by cosmic irradiation. The secondary muons…

Biological Physics · Physics 2019-11-07 Noemie Globus , Roger D. Blandford

Experimental mechanisms that yield the growth of homochiral copolymers over their heterochiral counterparts have been advocated by Lahav and co-workers. These chiral amplification mechanisms proceed through racemic {\beta}-sheet-controlled…

Quantitative Methods · Quantitative Biology 2012-12-19 Celia Blanco , David Hochberg

We study the pattern formation of chiral charges in the presence of reactions. We show that, in contrast to the original Turing's mechanism of pattern formation in diffusion-reaction systems, the interplay between chiral effects and…

Statistical Mechanics · Physics 2018-08-02 Naoki Yamamoto

The observed single-handedness of biological amino acids and sugars has long been attributed to autocatalysis. However, the stability of homochiral states in deterministic autocatalytic systems relies on cross inhibition of the two chiral…

Populations and Evolution · Quantitative Biology 2015-10-14 Farshid Jafarpour , Tommaso Biancalani , Nigel Goldenfeld

RNA in extant biological systems is homochiral; it consists exclusively of D-ribonucleotides rather than L-ribonucleotides. How the homochirality of RNA emerged is not known. Here, we use stochastic simulations to quantitatively explore the…

Biological Physics · Physics 2024-04-19 Gabin Laurent , Tobias Göppel , David Lacoste , Ulrich Gerland