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In the past several years, the problem of genome assembly has received considerable attention from both biologists and computer scientists. An important component of current assembly methods is the scaffolding process. This process involves…

Genomics · Quantitative Biology 2013-07-03 Karl R. B. Schmitt , Aleksey V. Zimin , Guillaume Marcaçs , James A. Yorke , Michelle Girvan

While critical for the practical progress of spectrum sharing, modulation recognition has so far been investigated under unrealistic assumptions: (i) a transmitter's bandwidth must be scanned alone and in full, (ii) prior knowledge of the…

Signal Processing · Electrical Eng. & Systems 2020-05-11 Wei Xiong , Karyn Doke , Petko Bogdanov , Mariya Zheleva

De novo genome assembly, i.e., rebuilding the sequence of an unknown genome from redundant and erroneous short sequences, is a key but computationally intensive step in many genomics pipelines. The exponential growth of genomic data is…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-07-12 Giulia Guidi , Gabriel Raulet , Daniel Rokhsar , Leonid Oliker , Katherine Yelick , Aydin Buluc

Dense pixel matching is important for many computer vision tasks such as disparity and flow estimation. We present a robust, unified descriptor network that considers a large context region with high spatial variance. Our network has a very…

Computer Vision and Pattern Recognition · Computer Science 2019-04-08 René Schuster , Oliver Wasenmüller , Christian Unger , Didier Stricker

SLiM is an efficient forward population genetic simulation designed for studying the effects of linkage and selection on a chromosome-wide scale. The program can incorporate complex scenarios of demography and population substructure,…

Populations and Evolution · Quantitative Biology 2013-01-15 Philipp W. Messer

Graph comparison is a fundamental operation in data mining and information retrieval. Due to the combinatorial nature of graphs, it is hard to balance the expressiveness of the similarity measure and its scalability. Spectral analysis…

Social and Information Networks · Computer Science 2020-03-04 Anton Tsitsulin , Marina Munkhoeva , Bryan Perozzi

Network analysis has played a key role in knowledge discovery and data mining. In many real-world applications in recent years, we are interested in mining multilayer networks, where we have a number of edge sets called layers, which encode…

Social and Information Networks · Computer Science 2022-11-08 Yasushi Kawase , Atsushi Miyauchi , Hanna Sumita

Despite the recent progress in genome sequencing and assembly, many of the currently available assembled genomes come in a draft form. Such draft genomes consist of a large number of genomic fragments (scaffolds), whose order and/or…

Genomics · Quantitative Biology 2022-05-27 Sergey Aganezov , Pavel Avdeyev , Nikita Alexeev , Yongwu Rong , Max A. Alekseyev

Superpixel algorithms have proven to be a useful initial step for segmentation and subsequent processing of images, reducing computational complexity by replacing the use of expensive per-pixel primitives with a higher-level abstraction,…

Computer Vision and Pattern Recognition · Computer Science 2018-07-24 Bradley C. Lowekamp , David T. Chen , Ziv Yaniv , Terry S. Yoo

Benefiting from its high efficiency and simplicity, Simple Linear Iterative Clustering (SLIC) remains one of the most popular over-segmentation tools. However, due to explicit enforcement of spatial similarity for region continuity, the…

Computer Vision and Pattern Recognition · Computer Science 2018-10-09 Jiaxing Zhao , Ren Bo , Qibin Hou , Ming-Ming Cheng , Paul L. Rosin

The homological scaffold leverages persistent homology to construct a topologically sound summary of a weighted network. However, its crucial dependency on the choice of representative cycles hinders the ability to trace back global…

Algebraic Topology · Mathematics 2021-01-05 Marco Guerra , Alessandro De Gregorio , Ulderico Fugacci , Giovanni Petri , Francesco Vaccarino

With the increasing affordability and accessibility of genome sequencing data, de novo genome assembly is an important first step to a wide variety of downstream studies and analyses. Therefore, bioinformatics tools that enable the…

Genomics · Quantitative Biology 2023-06-09 Lauren Coombe , René L. Warren , Johnathan Wong , Vladimir Nikolic , Inanc Birol

Motivation: The application of PacBio HiFi and ultra-long ONT reads have achieved huge progress in the contig-level assembly, but it is still challenging to assemble large contigs into chromosomes with available Hi-C scaffolding software,…

Genomics · Quantitative Biology 2021-12-01 Sen Wang , Hengchao Wang , Fan Jiang , Anqi Wang , Hangwei Liu , Hanbo Zhao , Boyuan Yang , Dong Xu , Yan Zhang , Wei Fan

Contrastive learning has recently attracted plenty of attention in deep graph clustering for its promising performance. However, complicated data augmentations and time-consuming graph convolutional operation undermine the efficiency of…

Machine Learning · Computer Science 2022-06-28 Yue Liu , Xihong Yang , Sihang Zhou , Xinwang Liu

We present an efficient algorithm for the least squares parameter fitting optimized for component separation in multi-frequency CMB experiments. We sidestep some of the problems associated with non-linear optimization by taking advantage of…

Cosmology and Nongalactic Astrophysics · Physics 2015-06-26 Rishi Khatri

While robotic manipulation of rigid objects is quite straightforward, coping with deformable objects is an open issue. More specifically, tasks like tying a knot, wiring a connector or even surgical suturing deal with the domain of…

Computer Vision and Pattern Recognition · Computer Science 2018-10-11 Daniele De Gregorio , Gianluca Palli , Luigi Di Stefano

In recent years, network models have gained prominence for their ability to capture complex associations. In statistical omics, networks can be used to model and study the functional relationships between genes, proteins, and other types of…

Methodology · Statistics 2023-06-21 Camilla Lingjærde , Sylvia Richardson

Matrix sketching is a recently developed data compression technique. An input matrix A is efficiently approximated with a smaller matrix B, so that B preserves most of the properties of A up to some guaranteed approximation ratio. In so…

Machine Learning · Statistics 2019-12-03 Roberta Falcone , Angela Montanari , Laura Anderlucci

Virtual Screening (VS) of vast compound libraries guided by Artificial Intelligence (AI) models is a highly productive approach to early drug discovery. Data splitting is crucial for better benchmarking of such AI models. Traditional random…

Quantitative Methods · Quantitative Biology 2024-07-02 Qianrong Guo , Saiveth Hernandez-Hernandez , Pedro J Ballester

Shifted-and-Duplicated-Kernel (SDK) mapping has emerged as an effective strategy to accelerate convolutional layers on compute-in-memory (CIM) hardware. However, existing SDK variants (e.g., VWC-SDK) merely optimize mapping for a single CIM…

Hardware Architecture · Computer Science 2026-04-29 Ke Dong , Kejie Huang , Tao Luo , Bo Wang
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