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Existing state-of-the-art methods that take a single RNA sequence and predict the corresponding RNA secondary-structure are thermodynamic methods. These predict the most stable RNA structure, but do not consider the process of structure…

Biomolecules · Quantitative Biology 2012-07-26 Jeff R. Proctor , Irmtraud M. Meyer

We study the thermodynamics and kinetics of an RNA toehold-mediated strand displacement reaction with a recently developed coarse-grained model of RNA. Strand displacement, during which a single strand displaces a different strand…

Biological Physics · Physics 2015-03-11 Petr Šulc , Thomas E. Ouldridge , Flavio Romano , Jonathan P. K. Doye , Ard A. Louis

Gas behavior in systems at microscale has been receiving significant attention from researchers in the last two decades [1-4]. Today, there is an enhanced emphasis on developing new experimental techniques to capture the local temperature…

Instrumentation and Detectors · Physics 2019-08-05 Varun Yeachana , Vikash Kumar , Lucien Baldas , Marcos Rojas-Cárdenas , Christine Barrot , Ryan Enright , Stéphane Colin

A prototype neutron detector has been created through modification to a commercial non-volatile flash memory device. Studies are being performed to modify this prototype into a purpose-built device with greater performance and…

Instrumentation and Detectors · Physics 2021-08-18 Tim Hossain , Clayton Fullwood , Will Flanagan , Peter Hedlesky , John Rabaey , Steven Block , Aidan Medcalf , Tracy Tipping

Taking advantage of phase-transition and reconfigurable metamaterials, dynamic control of nanoscale thermal modulation can be achieved through the near-field radiative thermal rectification devices. In this work, an active-tuning near-field…

Applied Physics · Physics 2020-06-01 Fangqi Chen , Xiaojie Liu , Yanpei Tian , Yi Zheng

The thermodynamical properties of heterogeneous DNA sequences are computed by path integral techniques applied to a nonlinear model Hamiltonian. The base pairs relative displacements are interpreted as time dependent paths whose amplitudes…

Statistical Mechanics · Physics 2010-05-12 Marco Zoli

In nature adaptive coloration has been effectively utilized for concealment and signaling. Various biological mechanisms have evolved that can tune the reflectivity for visible and ultraviolet light. These examples inspire many artificial…

Using simulations or experiments performed at some set of temperatures to learn about the physics or chemistry at some other arbitrary temperature is a problem of immense practical and theoretical relevance. Here we develop a framework…

Statistical Mechanics · Physics 2022-10-17 Yihang Wang , Lukas Herron , Pratyush Tiwary

The circadian clock can adapt itself to external cues, but the molecular mechanisms and regulatory networks governing circadian oscillations' transient adjustments are still largely unknown. Here we consider the specific case of circadian…

Molecular Networks · Quantitative Biology 2023-04-18 Ziyu Zhao , Dae-Sung Hwangbo , Sumit Saurabh , Clark Rosensweig , Ravi Allada , William L. Kath , Rosemary Braun

Measuring thermodynamic quantities can be easy or not, depending on the system that is being studied. For a macroscopic object, measuring temperatures can be as simple as measuring how much a column of mercury rises when in contact with the…

Quantum Physics · Physics 2015-09-15 O. P. de Sá Neto , M. C. de Oliveira , G. J. Milburn

The hotspots, which are typically found in nanogaps between metal structures, are critical for the enhancement of the electromagnetic field. Surface-enhanced Raman scattering (SERS), a technique known for its exceptional sensitivity and…

Refractive optics in astronomical instruments are potentially sensitive to temperature gradients and temperature transients. This sensitivity arises from thermally dependent refractive indices, lens spacings, and lens dimensions. We have…

Astrophysics · Physics 2014-10-13 Warren R. Brown , Daniel G. Fabricant , David A. Boyd

The rate of mRNA translation depends on the initiation, elongation, and termination rates of ribosomes along the mRNA. These rates depend on many "local" factors like the abundance of free ribosomes and tRNA molecules in the vicinity of the…

Subcellular Processes · Quantitative Biology 2021-02-25 Michael Margaliot , Wasim Huleihel , Tamir Tuller

We show that a mesoscale model, with a minimal number of parameters, can well describe the thermomechanical and mechanochemical behavior of homogeneous DNA at thermal equilibrium under tension and torque. We predict critical temperatures…

Biomolecules · Quantitative Biology 2015-06-22 Cristiano Nisoli , A. R. Bishop

In this paper we report direct measurement of large low frequency temperature fluctuations in double stranded (ds) DNA when it undergoes thermal denaturation transition. The fluctuation, which occurs only in the temperature range where the…

Statistical Mechanics · Physics 2007-05-23 K. S. Nagapriya , A. K. Raychaudhuri , Dipankar Chatterji

The material properties selection for designing acoustic filters with optimal performance over a range of frequencies requires considerable effort to fabricate and test laboratory samples. To simplify this procedure, one may test a single…

Materials Science · Physics 2016-12-01 Hossein Sadeghi , A. Srivastava , A. V. Amirkhizi , Sia Nemat-Nasser

Cells are known to utilize biochemical noise to probabilistically switch between distinct gene expression states. We demonstrate that such noise-driven switching is dominated by tails of probability distributions and is therefore…

Molecular Networks · Quantitative Biology 2009-11-13 Pankaj Mehta , Ranjan Mukhopadhyay , Ned S. Wingreen

Integrative biomolecular modeling of RNA relies on structural refined collections and accurate experimental data that reflect binding and folding behavior. However, the prediction of such collections remains challenging due to the rugged…

Active thermal control is crucial in achieving the required accuracy and throughput in many industrial applications, e.g., in the medical industry, high-power lighting industry, and semiconductor industry. Thermoelectric Modules (TEMs) can…

Systems and Control · Electrical Eng. & Systems 2020-06-19 Enzo Evers , Rens Slenders , Rob van Gils , Tom Oomen

A machine-learning non-contact method to determine the temperature of a laser gain medium via its laser emission with a trained few-layer neural net model is presented. The training of the feed-forward Neural Network (NN) enables the…

Optics · Physics 2024-10-31 Jakob Mannstadt , Arash Rahimi-Iman
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