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Path-integral molecular dynamics simulations and electronic structure-based energy decomposition analysis (EDA) are employed to connect hydrogen bond (H-bond) strength, its asymmetry, and the total delocalization energy at the water/air…

Chemical Physics · Physics 2026-02-03 Frederik Zysk , Ana Vila Verde , Naveen K. Kaliannan , Kristof Karhan , Thomas D. Kühne

We examine five different popular rigid water models (SPC, SPCE, TIP3P, TIP4P and TIP5P) using MD simulations in order to investigate the hydrophobic hydration and interaction of apolar Lennard-Jones solutes as a function of temperature in…

Soft Condensed Matter · Physics 2009-09-29 Dietmar Paschek

Diverse implicit structures of fluids are discovered lately, providing opportunities to study the physics of fluids applying network analysis. Although considerable works devote to identifying informative network structures of fluids, we…

Fluid Dynamics · Physics 2024-08-26 Yang Tian , Pei Sun , Yizhou Xu

A high level polarizable force field is used to study the temperature dependence of hydrophobic hydration of small-sized molecules from computer simulations. Molecular dynamics (MD) simulations of liquid water at various temperatures form…

Biological Physics · Physics 2007-11-27 R. Mahajan , D. Krazmueller , U. H. E. Hansmann , J. Volkert , S. Hoefinger

An understanding of the hydrophobicity of complex heterogeneous molecular assemblies is crucial to characterize and predict interactions between biomolecules. As such, uncovering the subtleties of assembly processes hinges on an accurate…

Soft Condensed Matter · Physics 2015-02-20 Richard C. Remsing , John D. Weeks

The physics of air-water interfaces plays a central role in modern theories of the hydrophobic effect. Implementing these theories, however, has been hampered by the difficulty of addressing fluctuations in the shape of such soft…

Statistical Mechanics · Physics 2016-05-27 Suriyanarayanan Vaikuntanathan , Phillip L Geissler

In the frame of collective dynamics in water, models built on elementary excitations and long-range electromagnetic interactions in the cell and bulk liquid are presented. Making use of the low effective mass of water coherence domains…

Biological Physics · Physics 2008-12-12 Eugen A. Preoteasa , Marian V. Apostol

Water near hydrophobic surfaces is like that at a liquid-vapor interface, where fluctuations in water density are substantially enhanced compared to that in bulk water. Here we use molecular simulations with specialized sampling techniques…

A comprehensive, semi-quantitative model for the thermodynamics of hydrophobic solvation is presented. The model is based on a very simple premise suggested by the scaled particle theory and treats both solute and solvent molecules as hard…

Biological Physics · Physics 2007-05-23 Hong Qian

We perform lengthy molecular dynamics simulations of the SPC/E model of water to investigate the dynamics under pressure at many temperatures and compare with experimental measurements. We calculate the isochrones of the diffusion constant…

Condensed Matter · Physics 2009-10-31 Francis W. Starr , Stephen Harrington , Francesco Sciortino , H. Eugene Stanley

By adopting a perspective informed by contemporary liquid state theory, we consider how to train an artificial neural network potential to describe inhomogeneous, disordered systems. We find that neural network potentials based on local…

Chemical Physics · Physics 2021-11-10 Samuel P. Niblett , Mirza Galib , David T. Limmer

Large scale modelling of fluid flow coupled with solid failure in geothermal reservoirs or hydrocarbon extraction from reservoir rocks usually involves behaviours at two scales: lower scale of the inelastic localization zone, and larger…

Soft Condensed Matter · Physics 2014-06-06 Giang D. Nguyen , Abbas El-Zein , Terry Bennett

The microscopic description of the local structure of water remains an open challenge. Here, we adopt an agnostic approach to understanding water's hydrogen bond network using data harvested from molecular dynamics simulations of an…

Soft Condensed Matter · Physics 2022-04-05 Adu Offei-Danso , Ali Hassanali , Alex Rodriguez

Describing the interactions of water molecules is one of the most common, yet critical, tasks in molecular dynamics simulations. Because of its unique properties, hundreds of attempts have been made to construct an ideal interaction…

Chemical Physics · Physics 2025-06-23 Bálint Soczó , Ildikó Pethes

The structure of liquid water in the proximity of an interface can deviate significantly from that of bulk water, with surface-induced structural perturbations typically converging to bulk values at about ~1 nm from the interface. While…

Soft Condensed Matter · Physics 2022-03-01 Piero Gasparotto , Martin Fitzner , Stephen J. Cox , Gabriele Cesare Sosso , Angelos Michaelides

We present an extension of our recently introduced molecular density functional theory of water [G. Jeanmairet et al., J. Phys. Chem. Lett. 4, 619, 2013] to the solvation of hydrophobic solutes of various sizes, going from angstroms to…

Chemical Physics · Physics 2013-10-21 Guillaume Jeanmairet , Maximilien Levesque , Daniel Borgis

A molecular theory of liquid water is identified and studied on the basis of computer simulation of the TIP3P model of liquid water. This theory would be exact for models of liquid water in which the intermolecular interactions vanish…

Chemical Physics · Physics 2009-11-13 J. K. Shah , D. Asthagiri , L. R. Pratt , M. E. Paulaitis

Hydrophobic interactions are central to biological self-assembly and soft matter organization, yet their microscopic origins remain debated. A key hallmark is the strengthening of attraction between hydrophobic solutes with increasing…

Soft Condensed Matter · Physics 2025-09-25 Nigel B. Wilding , Francesco Turci

We study some aspects of hydrophobic interaction between molecular rough and flexible model surfaces. The model we use in this work is based on a model we used previously (Eun, C.; Berkowitz, M. L. J. Phys. Chem. B 2009, 113, 13222-13228),…

Soft Condensed Matter · Physics 2011-06-03 Changsun Eun , Max L. Berkowitz

A theoretical model for the effect of water hydrogen bonding on the thermodynamics of hydrophobic hydration is proposed as a combination of the classical density functional theory with the recently developed probabilistic approach to water…

Statistical Mechanics · Physics 2011-06-16 Yuri S. Djikaev