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Continuum models for the spatial dynamics of growing cell populations have been widely used to investigate the mechanisms underpinning tissue development and tumour invasion. These models consist of nonlinear partial differential equations…

Tissues and Organs · Quantitative Biology 2019-07-15 Mark AJ Chaplain , Tommaso Lorenzi , Fiona R Macfarlane

This paper introduces a reaction-diffusion-chemotaxis model for bacterial aggregation patterns on the surface of thin agar plates. It is based on the non-linear degenerate cross diffusion model proposed by Kawasaki et al. (J. of Theor.…

Cell Behavior · Quantitative Biology 2013-01-23 J. Francisco Leyva , Carlos Malaga , Ramon G. Plaza

We derive general kinetic and hydrodynamic models of chemotactic aggregation that describe certain features of the morphogenesis of biological colonies (like bacteria, amoebae, endothelial cells or social insects). Starting from a…

Biological Physics · Physics 2009-11-13 Pierre-Henri Chavanis , Clement Sire

Under hard-agar and nutrient-rich conditions, a cell of $Bacillus$ $subtilis$ grows as a single filament owing to the failure of cell separation after each growth and division cycle. The self-elongating filament of cells shows sequential…

Soft Condensed Matter · Physics 2015-10-16 Ryojiro Honda , Jun-ichi Wakita , Makoto Katori

In this article a kinetic model for the dynamics of myxobacteria colonies on flat surfaces is investigated. The model is based on the kinetic equation for collective bacteria dynamics introduced in arXiv:2001.02711, which is based on the…

Analysis of PDEs · Mathematics 2021-09-28 Laura Kanzler , Christian Schmeiser

The emergent spatial patterns generated by growing bacterial colonies have been the focus of intense study in physics during the last twenty years. Both experimental and theoretical investigations have made possible a clear qualitative…

Statistical Mechanics · Physics 2011-08-10 Juan A. Bonachela , Carey D. Nadell , Joao B. Xavier , Simon A. Levin

Bacteria can spontaneously develop collective motions by aligning their motions in dense systems. Here, we show that bacteria can also respond collectively to an alternating electrical field and form dynamic clusters oscillating at the same…

Soft Condensed Matter · Physics 2022-10-11 Mei Mei Bao , Isaiah Eze Igwe , Kang Chen , Tian Hui Zhang

This paper proposes a model for the growth two interacting populations of cells that do not mix. The dynamics is driven by pressure and cohesion forces on the one hand and proliferation on the other hand. Following earlier works on the…

Cell Behavior · Quantitative Biology 2018-04-12 Alina Chertock , Pierre Degond , Sophie Hecht , Jean-Paul Vincent

A recently proposed single progenitor cell model for skin cell proliferation [Clayton et al., Nature v446, 185 (2007)] is extended to incorporate homeostasis as a fixed point of the dynamics. Unlimited cell proliferation in such a model can…

Cell Behavior · Quantitative Biology 2009-03-05 Patrick B. Warren

Bacteria are prolific at colonizing diverse surfaces under a widerange of environmental conditions, and exhibit fascinating examples of self-organization across scales. Though it has recently attracted considerable interest, the role of…

Soft Condensed Matter · Physics 2024-03-25 M. T. Khan , J. Cammann , A. Sengupta , E. Renzi , M. G. Mazza

We study the spreading of a bacterial colony undergoing turbulent like collective motion. We present two minimalistic models to investigate the interplay between population growth and coherent structures arising from turbulence. Using…

Fluid Dynamics · Physics 2017-04-06 Rayan Chatterjee , Abhijeet A. Joshi , Prasad Perlekar

Most of our understanding of bacterial chemotaxis comes from studies of Escherichia coli. However, recent evidence suggests significant departures from the E. coli paradigm in other bacterial species. This variation may stem from different…

Cell Behavior · Quantitative Biology 2015-03-27 Martin Godány , Bhavin S. Khatri , Richard A. Goldstein

Bacterial chemotaxis in Escherichia coli is a canonical system for the study of signal transduction. A remarkable feature of this system is the coexistence of precise adaptation in population with large fluctuating cellular behavior in…

Molecular Networks · Quantitative Biology 2019-08-19 Thierry Emonet , Philippe Cluzel

Growth (and resorption) of biological tissue is formulated in the continuum setting. The treatment is macroscopic, rather than cellular or sub-cellular. Certain assumptions that are central to classical continuum mechanics are revisited,…

Quantitative Methods · Quantitative Biology 2015-06-26 K. Garikipati , E. M. Arruda , K. Grosh , H. Narayanan , S. Calve

Monolayer cluster growth in far-from-equilibrium systems is investigated by applying simulation and analytic techniques to minimal hard core particle (exclusion) models. The first model (I), for post-deposition coarsening dynamics, contains…

Statistical Mechanics · Physics 2009-11-10 F. D. A. Aarao Reis , R. B. Stinchcombe

The recently established connection between stochastic thermodynamics and fluctuating hydrodynamics is applied to a study of efficiencies in the coupled transport of heat and matter on a small scale. A stochastic model for a mesoscopic cell…

Statistical Mechanics · Physics 2019-04-01 Jean-François Derivaux , Yannick De Decker

The transition from localized to systemic spreading of bacteria, viruses and other agents is a fundamental problem that spans medicine, ecology, biology and agriculture science. We have conducted experiments and simulations in a simple…

Populations and Evolution · Quantitative Biology 2009-11-10 Anna L. Lin , Bernward A. Mann , Gelsy Torres-Oviedo , Bryan Lincoln , Josef Kas , Harry L. Swinney

Cancer cells co-cultured in vitro reveal unexpected differential growth rates that classical exponential growth models cannot account for. Two non-interacting cell lines were grown in the same culture, and counts of each species were…

Quantitative Methods · Quantitative Biology 2014-12-04 Agnès Hamon , Marie Tosolini , Bernard Ycart , Pont Frédéric , Jean-Jacques Fournié

We suggest a natural approach that leads to a modification of classical quasispecies models and incorporates the possibility of population extinction in addition to growth. The resulting modified models are called open. Their essential…

Populations and Evolution · Quantitative Biology 2019-03-25 Ivan Yegorov , Artem S. Novozhilov , Alexander S. Bratus

How are granular details of stochastic growth and division of individual cells reflected in smooth deterministic growth of population numbers? We provide an integrated, multiscale perspective of microbial growth dynamics by formulating a…