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Software configuration tuning is essential for optimizing a given performance objective (e.g., minimizing latency). Yet, due to the software's intrinsically complex configuration landscape and expensive measurement, there has been a rather…

Software Engineering · Computer Science 2024-03-18 Pengzhou Chen , Tao Chen , Miqing Li

The first purpose of this paper is to shed some new light on the old question of selecting the number of beams in intensity-modulated radiation therapy (IMRT). The second purpose is to illuminate the related issue of discrete static beam…

Medical Physics · Physics 2015-05-14 Thomas Bortfeld

Noncoplanar radiation therapy treatment planning has the potential to improve dosimetric quality as compared to traditional coplanar techniques. Likewise, automated treatment planning algorithms can reduce a planner's active treatment…

Medical Physics · Physics 2022-01-19 Charles Huang , Yong Yang , Lei Xing

Purpose: To quantitatively compare the dosimetric and biologic differences in treatment plans from flattened and flattening-filter-free (FFF) beam for three anatomic cancer sites. Methods and Materials: Treatment plans with static…

Medical Physics · Physics 2015-06-18 Yue Yan , Poonam Yadav , Michael Bassetti , Kaifang Du , Daniel Saenz , Paul Harari , Bhudatt R. Paliwal

Bayesian Optimization (BO) is a common approach for hyperparameter optimization (HPO) in automated machine learning. Although it is well-accepted that HPO is crucial to obtain well-performing machine learning models, tuning BO's own…

Machine Learning · Computer Science 2019-08-20 Marius Lindauer , Matthias Feurer , Katharina Eggensperger , André Biedenkapp , Frank Hutter

The initial alignment provides an accurate attitude for SINS (strapdown inertial navigation system). By further estimating the IMU's bias and misalignment angle, the recursive Bayesian filter is accurate. However, the prior heading error…

Robotics · Computer Science 2023-06-07 Hanwen Zhou , Xiufen Ye

he segment minimization problem consists of finding the smallest set of integer matrices that sum to a given intensity matrix, such that each summand has only one non-zero value, and the non-zeroes in each row are consecutive. This has…

Data Structures and Algorithms · Computer Science 2011-09-27 Therese Biedl , Stephane Durocher , Holger H. Hoos , Shuang Luan , Jared Saia , Maxwell Young

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…

Medical Physics · Physics 2018-12-03 Dan Nguyen , Troy Long , Xun Jia , Weiguo Lu , Xuejun Gu , Zohaib Iqbal , Steve Jiang

Intensity-modulated radiation therapy (IMRT) allows for the design of customized, highly-conformal treatments for cancer patients. Creating IMRT treatment plans, however, is a mathematically complex process, which is often tackled in…

Optimization and Control · Mathematics 2022-03-18 Danielle A. Ripsman , Thomas G. Purdie , Timothy C. Y. Chan , Houra Mahmoudzadeh

Purpose: Patient-specific ridge filters can modulate proton energy to obtain a conformal dose. We describe a new framework for optimization of filter design and spot maps to meet the unique demands of FLASH radiotherapy. We demonstrate an…

Drones are effective for reducing human activity and interactions by performing tasks such as exploring and inspecting new environments, monitoring resources and delivering packages. Drones need a controller to maintain stability and to…

Systems and Control · Electrical Eng. & Systems 2021-05-19 Azin Shamshirgaran , Hamed Javidi , Dan Simon

Bayesian optimization (BO) is a sample efficient approach to automatically tune the hyperparameters of machine learning models. In practice, one frequently has to solve similar hyperparameter tuning problems sequentially. For example, one…

Machine Learning · Computer Science 2021-02-26 Samuel Horváth , Aaron Klein , Peter Richtárik , Cédric Archambeau

Bayesian Optimization (BO) is a foundational strategy in the field of engineering design optimization for efficiently handling black-box functions with many constraints and expensive evaluations. This paper introduces a fast and accurate BO…

Computational Engineering, Finance, and Science · Computer Science 2024-04-09 Rosen , Yu , Cyril Picard , Faez Ahmed

Functional Magnetic Resonance Imaging (fMRI) relies on multi-step data processing pipelines to accurately determine brain activity; among them, the crucial step of spatial smoothing. These pipelines are commonly suboptimal, given the local…

Computer Vision and Pattern Recognition · Computer Science 2017-10-03 Albert Vilamala , Kristoffer Hougaard Madsen , Lars Kai Hansen

Bayesian Optimization (BO) is an effective method for finding the global optimum of expensive black-box functions. However, it is well known that applying BO to high-dimensional optimization problems is challenging. To address this issue, a…

Machine Learning · Statistics 2024-02-06 Lam Ngo , Huong Ha , Jeffrey Chan , Vu Nguyen , Hongyu Zhang

According to the physical phenomena of atmospheric channels and wave propagation, performance of wireless communication systems can be optimized by simply adjusting its parameters. This way is more economically favorable than consuming…

Signal Processing · Electrical Eng. & Systems 2018-02-23 Mohammad Ali Amirabadi , Vahid Tabataba Vakili

Bayesian Optimization (BO) is a powerful tool for optimizing complex non-linear systems. However, its performance degrades in high-dimensional problems with tightly coupled parameters and highly asymmetric objective landscapes, where…

Machine Learning · Computer Science 2026-02-12 Aashwin Mishra , Matt Seaberg , Ryan Roussel , Daniel Ratner , Apurva Mehta

Bayesian Optimization (BO) is an efficient tool for optimizing black-box functions, but its theoretical guarantees typically hold in the asymptotic regime. In many critical real-world applications such as drug discovery or materials design,…

Machine Learning · Computer Science 2025-11-04 Diantong Li , Kyunghyun Cho , Chong Liu

The steep dose gradients obtained with pencil beam scanning allow for precise tumor targeting at the cost of high sensitivity to uncertainties. Robust optimization is commonly applied to mitigate uncertainties in density and patient setup,…

Medical Physics · Physics 2024-11-26 Ivar Bengtsson , Anders Forsgren , Albin Fredriksson , Ye Zhang

Bayesian Optimization (BO) is a common solution to search optimal hyperparameters based on sample observations of a machine learning model. Existing BO algorithms could converge slowly even collapse when the potential observation noise…

Computer Vision and Pattern Recognition · Computer Science 2022-10-10 Lei Cui , Yangguang Li , Xin Lu , Dong An , Fenggang Liu