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Conventional planning objectives in optimization of intensity-modulated radiotherapy treatment (IMRT) plans are designed to minimize the violation of dose-volume histogram (DVH) thresholds using penalty functions. Although successful in…

Medical Physics · Physics 2023-07-19 Lovisa Engberg , Kjell Eriksson , Anders Forsgren , Björn Hårdemark

Multi-objective optimization (MOO) aims to optimize multiple, possibly conflicting objectives with widespread applications. We introduce a novel interacting particle method for MOO inspired by molecular dynamics simulations. Our approach…

Machine Learning · Computer Science 2024-11-22 Yinuo Ren , Tesi Xiao , Tanmay Gangwani , Anshuka Rangi , Holakou Rahmanian , Lexing Ying , Subhajit Sanyal

Fine-tuning Large Language Models (LLMs) with Low-Rank Adaptation (LoRA) offers a resource-efficient way to personalize or specialize. However, LoRA is highly sensitive to hyperparameter choices, and exhaustive hyperparameter search is…

Computation and Language · Computer Science 2026-05-29 Baek Seong-Eun , Lee Jung-Mok , Kim Sung-Bin , Tae-Hyun Oh

We have developed a multi-objective optimization (MOO) procedure to construct modified-embedded-atom-method (MEAM) potentials with minimal manual fitting. This procedure has been applied successfully to develop a new MEAM potential for…

Parametric multi-objective optimization (PMO) addresses the challenge of solving an infinite family of multi-objective optimization problems, where optimal solutions must adapt to varying parameters. Traditional methods require re-execution…

Neural and Evolutionary Computing · Computer Science 2025-11-11 Ji Cheng , Bo Xue , Qingfu Zhang

We conduct a theoretical study of various solution methods for the adaptive fractionation problem. The two messages of this paper are: (i) dynamic programming (DP) is a useful framework for adaptive radiation therapy, particularly adaptive…

Medical Physics · Physics 2012-02-16 Jagdish Ramakrishnan , David Craft , Thomas Bortfeld , John N. Tsitsiklis

Objective: Radiation therapy treatment planning is a time-consuming process involving iterative adjustments of hyperparameters. To automate the treatment planning process, we propose a meta-optimization framework, called MetaPlanner (MP).…

Medical Physics · Physics 2022-02-22 Charles Huang , Yusuke Nomura , Yong Yang , Lei Xing

This paper presents reduced-rank linearly constrained minimum variance (LCMV) beamforming algorithms based on joint iterative optimization of filters. The proposed reduced-rank scheme is based on a constrained joint iterative optimization…

Other Computer Science · Computer Science 2012-05-22 R. C. de Lamare , L. Wang , R. Fa

Bayesian Optimization (BO) has been recognized for its effectiveness in optimizing expensive and complex objective functions. Recent advancements in Latent Bayesian Optimization (LBO) have shown promise by integrating generative models such…

Machine Learning · Computer Science 2025-04-22 Seunghun Lee , Jinyoung Park , Jaewon Chu , Minseo Yoon , Hyunwoo J. Kim

A framework for online robust adaptive radiation therapy (ART) is presented. This framework is designed to (i) handle interfractional geometric variations following a probability distribution different from the a priori hypothesis, (ii)…

Medical Physics · Physics 2020-09-09 Michelle Böck

The cost of simulating quantum many-body systems - on classical or quantum hardware - scales with the number of variational parameters, so progress at fixed computational budget hinges on more parameter-efficient ans\"atze. Configuration…

Quantum Physics · Physics 2026-05-25 Hao Zhang , Matthew Otten

Automatically tuning software configuration for optimizing a single performance attribute (e.g., minimizing latency) is not trivial, due to the nature of the configuration systems (e.g., complex landscape and expensive measurement). To deal…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-06-03 Tao Chen , Miqing Li

In this paper, we propose a practical adaptive coding modulation scheme to approach the capacity of free-space optical (FSO) channels with intensity modulation/direct detection based on probabilistic shaping. The encoder efficiently adapts…

Information Theory · Computer Science 2020-12-01 Ahmed Elzanaty , Mohamed-Slim Alouini

Efficient design of genomic perturbation experiments is crucial for accelerating drug discovery and therapeutic target identification, yet exhaustive perturbation of the human genome remains infeasible due to the vast search space of…

Machine Learning · Statistics 2026-03-24 Yanke Li , Tianyu Cui , Tommaso Mansi , Mangal Prakash , Rui Liao

Background: Ultra-high-dose-rate (UHDR) radiation therapy has demonstrated promising potential in reducing toxicity to organs-at-risk (OARs). Proton therapy is uniquely positioned to deliver UHDR by leveraging the Bragg peak in conjunction…

Medical Physics · Physics 2025-04-30 Jiayue Han , Ya-Nan Zhu , Aoxiang Wang , Wangyao Li , Yuting Lin , Hao Gao

Bayesian optimization (BO) is a popular framework to optimize black-box functions. In many applications, the objective function can be evaluated at multiple fidelities to enable a trade-off between the cost and accuracy. To reduce the…

Machine Learning · Computer Science 2020-12-11 Shibo Li , Wei Xing , Mike Kirby , Shandian Zhe

Low power oriented circuit optimization consists in selecting the best alternative between gate sizing, buffer insertion and logic structure transformation, for satisfying a delay constraint at minimum area cost. In this paper we used a…

Hardware Architecture · Computer Science 2011-11-09 A. Verle , X. Michel , N. Azemard , P. Maurine , D. Auvergne

Reliable visual perception under low illumination remains a core challenge for autonomous robotic systems, where degraded image quality directly compromises navigation, inspection, and various operations. A recent training free approach…

Computer Vision and Pattern Recognition · Computer Science 2026-04-27 Nathan Shankar , Pawel Ladosz , Hujun Yin

Purpose: To develop a novel aperture-based algorithm for volumetric modulated arc therapy (VMAT) treatment plan optimization with high quality and high efficiency. Methods: The VMAT optimization problem is formulated as a large-scale convex…

Medical Physics · Physics 2015-05-19 Chunhua Men , H. Edwin Romeijn , Xun Jia , Steve B. Jiang

In millimeter-wave (mmWave) communications, directional transmission based on beamforming is important to compensate for high pathloss. To maintain the desired direction transmission gain, beam scanning that involves the transmitter sending…

Systems and Control · Electrical Eng. & Systems 2024-01-02 Huang-Chou Lin , Kuang-Hao , Liu
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