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Decoding sequences that stem from multiple transmissions of a codeword over an insertion, deletion, and substitution channel is a critical component of efficient deoxyribonucleic acid (DNA) data storage systems. In this paper, we consider a…

Information Theory · Computer Science 2022-09-13 Issam Maarouf , Andreas Lenz , Lorenz Welter , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat

We introduce an algorithm that conjectures the structure of a permutation class in the form of a disjoint cover of "rules"; similar to generalized grid classes. The cover is usually easily verified by a human and translated into an…

Combinatorics · Mathematics 2017-05-12 Christian Bean , Bjarki Gudmundsson , Henning Ulfarsson

Nowadays there are several classes of constrained codes intended for different applications. The following two large classes can be distinguished. The first class contains codes with local constraints; for example, the source data must be…

Information Theory · Computer Science 2024-05-27 Boris Ryabko

In this study we determine the structure of reversible DNA codes obtained from skew cyclic codes. We show that the generators of such DNA codes enjoy some special properties. We study the structural properties of such family of codes and we…

Combinatorics · Mathematics 2017-03-31 Fatmanur Gursoy , Elif Segah Oztas , Irfan Siap

All known terrestrial proteins are coded as continuous strings of ~20 amino acids. The patterns formed by the repetitions of elements in groups of finite sequences describes the natural architectures of protein families. We present a method…

Biomolecules · Quantitative Biology 2018-07-30 Pablo Turjanski , Diego U. Ferreiro

We supply basic tools for the study of the topological order of a multiplet which is an eigenspace of a finite-dimensional normal operator with continuous parameters. We allow intrinsic degeneracies within the multiplet where a well-known…

Mesoscale and Nanoscale Physics · Physics 2009-11-10 Yasuhiro Hatsugai

Present day data allow significant reconsideration of ideas on mechanisms underlying the degeneracy in the genetic code. Here a hypothesis is presented which links the degeneracy to possible conformational alterations in the codon-anticodon…

Biological Physics · Physics 2013-10-14 Denis A. Semyonov

This paper studies two problems that are motivated by the novel recent approach of composite DNA that takes advantage of the DNA synthesis property which generates a huge number of copies for every synthesized strand. Under this paradigm,…

Information Theory · Computer Science 2025-05-15 Tomer Cohen , Eitan Yaakobi

We give algorithms to compute decompositions of a given polynomial, or more generally mixed tensor, as sum of rank one tensors, and to establish whether such a decomposition is unique. In particular, we present methods to compute the…

Algebraic Geometry · Mathematics 2021-07-12 Antonio Laface , Alex Massarenti , Rick Rischter

With the number of sequenced genomes now over one hundred, and the availability of rough functional annotations for a substantial proportion of their genes, it has become possible to study the statistics of gene content across genomes. Here…

Biological Physics · Physics 2007-05-23 Erik van Nimwegen

In this work, we investigate a challenging problem, which has been considered to be an important criterion in designing codewords for DNA computing purposes, namely secondary structure avoidance in single-stranded DNA molecules. In short,…

Information Theory · Computer Science 2023-02-28 Tuan Thanh Nguyen , Kui Cai , Han Mao Kiah , Duc Tu Dao , Kees A. Schouhamer Immink

A primitive $k$-batch code encodes a string $x$ of length $n$ into string $y$ of length $N$, such that each multiset of $k$ symbols from $x$ has $k$ mutually disjoint recovering sets from $y$. We develop new explicit and random coding…

Information Theory · Computer Science 2019-01-23 Nikita Polyanskii , Ilya Vorobyev

A permutation-invariant quantum code on $N$ qudits is any subspace stabilized by the matrix representation of the symmetric group $S_N$ as permutation matrices that permute the underlying $N$ subsystems. When each subsystem is a complex…

Quantum Physics · Physics 2017-07-04 Yingkai Ouyang

It is a well-known fact that genetic sequences may contain sections with repeated units, called repeats, that differ in length over a population, with a length distribution of geometric type. A simple class of recombination models with…

Dynamical Systems · Mathematics 2010-02-09 Michael Baake

We introduce a geometric invariant of knots in the three-sphere, called the first-order genus, that is derived from certain 2-complexes called gropes, and we show it is computable for many examples. While computing this invariant, we draw…

Geometric Topology · Mathematics 2009-11-13 Peter Horn

Motivated by the sequence reconstruction problem from traces in DNA-based storage, we consider the problem of designing codes for the deletion channel when multiple observations (or traces) are available to the decoder. We propose simple…

Information Theory · Computer Science 2019-06-26 Mahed Abroshan , Ramji Venkataramanan , Lara Dolecek , Albert Guillén i Fàbregas

Imposing a minimum principle in the framework of the so called crystal basis model of the genetic code, we determine the structure of the minimum set of 22 anticodons which allows the translational-transcription for animal mitochondrial…

Quantitative Methods · Quantitative Biology 2014-06-06 A. Sciarrino , P. Sorba

To synthesize peptides alongside the RNAs making the so-called RNA world, some genetic coding involving RNA had to develop. Herein, it is proposed that the first real-coding setup was a direct one, made up of continuous poly-tRNA-like…

Populations and Evolution · Quantitative Biology 2020-04-17 Jacques H. Daniel

A system-level genetic code is a hypothetical genetic code that exclusively or preferentially codes systems of interacting coadapted parts. System-level genetic codes differ from part-level genetic codes in which each discrete part is coded…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 John F. McGowan

This note presents a descending method that allows us to classify quotients of Reed-Muller codes of lenghth 128 under the action of the affine general linear group.

Discrete Mathematics · Computer Science 2023-05-05 Valérie Gillot , Philippe Langevin