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The neural coding is yet to be discovered. The neuronal operational modes that arise with fixed inputs but with varying degrees of stimulation help to elucidate their coding properties. In neurons receiving {\it in vivo} stimulation, we…
Network architecture forms a critical constraint on neuronal function. Here we examine the role of structural autapses, when a neuron synapses onto itself, in driving network-wide bursting behavior. Using a simple spiking model of neuronal…
We consider a threshold-crossing spiking process as a simple model for the activity within a population of neurons. Assuming that these neurons are driven by a common fluctuating input with Gaussian statistics, we evaluate the…
Single trial analyses of ensemble activity in alert animals demonstrate that cortical circuits dynamics evolve through temporal sequences of metastable states. Metastability has been studied for its potential role in sensory coding, memory…
Background: The roles of neuromodulation in a neural network, such as in a cortical microcolumn, are still incompletely understood. Neuromodulation influences neural processing by presynaptic and postsynaptic regulation of synaptic…
We investigate the stimulus-dependent tuning properties of a noisy ionic conductance model for intrinsic subthreshold oscillations in membrane potential and associated spike generation. On depolarization by an applied current, the model…
Adaptation to environmental change is a common property of biological systems. Cells initially respond to external changes in the environment, but after some time, they regain their original state. By considering an element consisting of…
We address the questions of identifying pairs of interacting neurons from the observation of their spiking activity. The neuronal network is modeled by a system of interacting point processes with memory of variable length. The influence of…
Modeling and simulating how oxygen supply shapes neuronal excitability is crucial for advancing the understanding of brain function in pathological scenarios, such as ischemia. This condition is caused by a reduced blood supply, leading to…
We propose a new model based on the Ising model with the aim to study synaptic plasticity phenomena in neural networks. It is today well established in biology that the synapses or connections between certain types of neurons are…
Population-wide oscillations are ubiquitously observed in mesoscopic signals of cortical activity. In these network states a global oscillatory cycle modulates the propensity of neurons to fire. Synchronous activation of neurons has been…
We study statistical properties of the irregular bursting arising in a class of neuronal models close to the transition from spiking to bursting. Prior to the transition to bursting, the systems in this class develop chaotic attractors,…
A continuous train of irregularly spaced spikes, peculiar of homoclinic chaos, transforms into clusters of regularly spaced spikes, with quiescent periods in between (bursting regime), by feeding back a low frequency portion of the…
We report the first results of simulating the coupling of neuronal, astrocyte, and cerebrovascular activity. It is suggested that the dynamics of the system is different from systems that only include neurons. In the neuron-vascular…
This work introduces a novel methodology for designing biologically plausible bursting neuron circuits using a minimal number of components. We hypothesize that to design circuits capable of bursting, the neuron circuit design must mimic a…
The dynamics of a wide range of real systems, from email patterns to earthquakes, display a bursty, intermittent nature, characterized by short timeframes of intensive activity followed by long times of no or reduced activity. The…
The spiking activity of neocortical neurons exhibits a striking level of variability, even when these networks are driven by identical stimuli. The approximately Poisson firing of neurons has led to the hypothesis that these neural networks…
Self-sustained subthreshold oscillations in a discrete-time model of neuronal behavior are considered. We discuss bifurcation scenarios explaining the birth of these oscillations and their transformation into tonic spikes. Specific features…
Several studies have shown that bursting neurons can encode information in the number of spikes per burst: As the stimulus varies, so does the length of individual bursts. The represented stimuli, however, vary substantially among different…
In this paper we present a simple microscopic stochastic model describing short term plasticity within a large homogeneous network of interacting neurons. Each neuron is represented by its membrane potential and by the residual calcium…