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Biological information processing networks consist of many components, which are coupled by an even larger number of complex multivariate interactions. However, analyses of data sets from fields as diverse as neuroscience, molecular…

Quantitative Methods · Quantitative Biology 2016-03-23 Lina Merchan , Ilya Nemenman

The human brain is a complex system defined by multi-way, higher-order interactions invisible to traditional pairwise network models. Although a diverse array of analytical methods has been developed to address this shortcoming, the field…

Quantitative Methods · Quantitative Biology 2025-11-11 Mohamma Reza Salehi , Ali BashirGonbadi , Hamid Soltanian-Zadeh

Understanding how stimuli and synaptic connectivity in uence the statistics of spike patterns in neural networks is a central question in computational neuroscience. Maximum Entropy approach has been successfully used to characterize the…

Biological Physics · Physics 2016-11-26 Rodrigo Cofre , Bruno Cessac

Maximum entropy models are increasingly being used to describe the collective activity of neural populations with measured mean neural activities and pairwise correlations, but the full space of probability distributions consistent with…

Biological Physics · Physics 2017-08-22 Badr F. Albanna , Christopher Hillar , Jascha Sohl-Dickstein , Michael R. DeWeese

Simultaneous recordings from multiple neural units allow us to investigate the activity of very large neural ensembles. To understand how large ensembles of neurons process sensory information, it is necessary to develop suitable…

Neurons and Cognition · Quantitative Biology 2013-05-30 Fernando Montani , Elena Phoka , Mariela Portesi , Simon R. Schultz

Ising models with pairwise interactions are the least structured, or maximum-entropy, probability distributions that exactly reproduce measured pairwise correlations between spins. Here we use this equivalence to construct Ising models that…

Neurons and Cognition · Quantitative Biology 2007-05-23 Gasper Tkacik , Elad Schneidman , Michael J Berry , William Bialek

Spiking neural network models characterize the emergent collective dynamics of circuits of biological neurons and help engineer neuro-inspired solutions across fields. Most dynamical systems' models of spiking neural networks typically…

Computational Physics · Physics 2023-04-12 Georg Börner , Fabio Schittler Neves , Marc Timme

The characterization of network and biophysical properties from neural spiking activity is an important goal in neuroscience. A framework that provides unbiased inference on causal synaptic interaction and single neural properties has been…

Neurons and Cognition · Quantitative Biology 2024-05-27 Kevin S. Chen , Ying-Jen Yang

Correlations are employed in modern physics to explain microscopic and macroscopic phenomena, like the fractional quantum Hall effect and the Mott insulator state in high temperature superconductors and ultracold atoms. Simultaneously…

Neurons and Cognition · Quantitative Biology 2013-02-20 Moritz Helias , Tom Tetzlaff , Markus Diesmann

Synchronization of coupled oscillators is observed in many natural and engineered systems and emerges due to the interactions within the system. It can be both beneficial, e.g., in power grids, and harmful, e.g., in epileptic seizures. In…

Adaptation and Self-Organizing Systems · Physics 2026-02-18 Martin Moriamé , Riccardo Muolo , Timoteo Carletti , Maxime Lucas

Many biological neuronal networks exhibit highly variable spiking activity. Balanced networks offer a parsimonious model of this variability. In balanced networks, strong excitatory synaptic inputs are canceled by strong inhibitory inputs…

Neurons and Cognition · Quantitative Biology 2016-05-04 Ryan Pyle , Robert Rosenbaum

Higher-order interactions underlie complex phenomena in systems such as biological and artificial neural networks, but their study is challenging due to the scarcity of tractable models. By leveraging a generalisation of the maximum entropy…

Disordered Systems and Neural Networks · Physics 2025-12-10 Miguel Aguilera , Pablo A. Morales , Fernando E. Rosas , Hideaki Shimazaki

The studies of collective oscillations induced by higher-order interactions point out the necessity of group effect in coupling modelization. As yet the related advances are mainly concentrated on nonlinear coupling patterns and cannot be…

Adaptation and Self-Organizing Systems · Physics 2022-03-31 Cong Liu , Chong-Yang Wang , Zhi-Xi Wu , Jian-Yue Guan

Several types of biological networks have recently been shown to be accurately described by a maximum entropy model with pairwise interactions, also known as the Ising model. Here we present an approach for finding the optimal mappings…

Biological Physics · Physics 2015-05-14 Jeffrey D. Fitzgerald , Tatyana O. Sharpee

Ising models with pairwise interactions are the least structured, or maximum-entropy, probability distributions that exactly reproduce measured pairwise correlations between spins. Here we use this equivalence to construct Ising models that…

Neurons and Cognition · Quantitative Biology 2009-12-31 Gasper Tkacik , Elad Schneidman , Michael J. Berry , William Bialek

Empirical complex systems can be characterized not only by pairwise interactions, but also by higher-order (group) interactions influencing collective phenomena, from metabolic reactions to epidemics. Nevertheless, higher-order networks'…

Physics and Society · Physics 2026-01-01 Maxime Lucas , Luca Gallo , Arsham Ghavasieh , Federico Battiston , Manlio De Domenico

Financial markets are a typical example of complex systems where interactions between constituents lead to many remarkable features. Here, we show that a pairwise maximum entropy model (or auto-logistic model) is able to describe switches…

Statistical Finance · Quantitative Finance 2014-01-28 Thomas Bury

We designed a model-based analysis to predict the occurrence of population patterns in distributed spiking activity. Using a maximum entropy principle with a Markovian assumption, we obtain a model that accounts for both spatial and…

Neurons and Cognition · Quantitative Biology 2009-11-13 Olivier Marre , Sami El Boustani , Yves Fregnac , Alain Destexhe

Maximum entropy methods provide a principled path connecting measurements of neural activity directly to statistical physics models, and this approach has been successful for populations of $N\sim 100$ neurons. As $N$ increases in new…

Biological Physics · Physics 2023-10-18 Christopher W. Lynn , Qiwei Yu , Rich Pang , William Bialek , Stephanie E. Palmer

This paper introduces a class of stochastic models of interacting neurons with emergent dynamics similar to those seen in local cortical populations, and compares them to very simple reduced models driven by the same mean excitatory and…

Neurons and Cognition · Quantitative Biology 2017-11-07 Yao Li , Logan Chariker , Lai-Sang Young