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Single-molecule detection enables direct observation of individual biomolecular events, providing mechanistic insights into biological processes and offering a powerful tool for disease diagnostics. However, the fundamental scale mismatch…

Optics · Physics 2025-10-14 Guifeng Li , Chaoyang Gong

Super-resolution fluorescence microscopy is of great interest in life science studies for visualizing subcellular structures at the nanometer scale. Among various kinds of super-resolution approaches, image scanning microscopy (ISM) offers…

When an electromagnetic wave is obliquely incident on an inhomogeneous high density plasma, it will be absorbed resonantly as long as it is polarized in the plane of incidence and has an electric field component along the plasma electron…

Plasma Physics · Physics 2009-01-27 S J Pestehe , M Mohammadnejad

Fourier transform spectroscopy based on incoherent light sources is a well-established tool in research fields from molecular spectroscopy and atmospheric monitoring to material science and biophysics. It provides broadband molecular…

The impulse response function (IRF) of a localized bolus in cerebral blood flow codes important information on the tissue type. It is indirectly accessible both from MR- and CT-imaging methods, at least in principle. In practice, however,…

Tissues and Organs · Quantitative Biology 2014-09-30 Evelyn Rost , Ralf Geske , Michael Baake

A novel method for measuring the surface coverage of randomly distributed cylindrical nanoparticles such as nanorods and nanowires, using atomic force microscopy (AFM), is presented. The method offers several advantages over existing…

Materials Science · Physics 2018-07-12 Francesca Bottacchi , Stefano Bottacchi , Thomas D. Anthopoulos

Laser enhanced field evaporation of surface atoms in Laser-assisted Atom Probe Tomography (La-APT) can simultaneously excite phtotoluminescence in semiconductor or insulating specimens. An atom probe equipped with appropriate focalization…

Local feature detection is a key ingredient of many image processing and computer vision applications, such as visual odometry and localization. Most existing algorithms focus on feature detection from a sharp image. They would thus have…

Computer Vision and Pattern Recognition · Computer Science 2022-11-30 Zhenjun Zhao , Yu Zhai , Ben M. Chen , Peidong Liu

High harmonic spectroscopy has the potential to combine attosecond temporal with sub-Angstrom spatial resolution of the early nuclear and multielectron dynamics in molecules. It involves strong field ionization of the molecule by the IR…

Atomic Physics · Physics 2013-08-08 Valeria Serbinenko , Olga Smirnova

Spectroscopic photoemission microscopy is a well-established method to investigate the electronic structure of surfaces. In modern photoemission microscopes the electron optics allows imaging of the image plane, momentum plane, or…

In spite of their ubiquitous applications, the characterization of glass fibers by means of all-optical techniques is still facing some limitations. Recently, X-ray absorption has been proposed as a method for visualizing the inner…

Optical detection of nanoscale objects without relying on fluorescence is a current challenge due to their extremely weak interaction with light. Resonator-enhanced absorption microscopy is a novel tool to heavily boost the light-matter…

Spectral imaging is a method in medical x-ray imaging to extract information about the object constituents by the material-specific energy dependence of x-ray attenuation. Contrast-enhanced spectral imaging has been thoroughly investigated,…

Medical Physics · Physics 2021-01-26 Erik Fredenberg , Magnus Aslund , Bjorn Cederstrom , Mats Lundqvist , Mats Danielsson

We measure the absolute absorption cross section of molecules using a matter-wave interferometer. A nanostructured density distribution is imprinted onto a dilute molecular beam through quantum interference. As the beam crosses the light…

Quantum Physics · Physics 2014-08-20 Sandra Eibenberger , Xiaxi Cheng , J. P. Cotter , Markus Arndt

Strong constraints on possible variations in fundamental constants can be derived from HI 21-cm and molecular rotational absorption lines observed towards quasars. With the aim of forming a statistical sample of constraints we have begun a…

Astrophysics · Physics 2016-08-16 S. J. Curran , J. K. Webb , M. T. Murphy , Y. M. Pihlström

Biophysical force spectroscopy tools - for example optical tweezers, magnetic tweezers, atomic force microscopy, - have been used to study elastic, mechanical, conformational and dynamic properties of single biological specimens from single…

Biomolecules · Quantitative Biology 2016-06-09 Zhaokun Zhou , Mark C. Leake

Conventional absorption spectroscopy relies on coherent laser sources, and in turn suffers from the inherent limitation of shot noise, especially in estimating weak absorption. Here we propose a measurement strategy with correlated photons…

Quantum Physics · Physics 2025-04-17 Zhucheng Zhang , Xue Zhang , Jing Liu , Hui Dong

Spatial Frequency Domain Imaging can map tissue scattering and absorption properties over a wide field of view, making it useful for clinical applications such as wound assessment and surgical guidance. This technique has previously…

Biological Physics · Physics 2021-02-24 Mason T. Chen , Melina Papadakis , Nicholas J. Durr

We previously demonstrated near-field speckle scanning based x-ray imaging to be an easy-to-implement phase sensing method capable of providing both high sensitivity and high resolution. Yet, this performance combination could only be…

Medical Physics · Physics 2017-06-21 Sebastien Berujon , Eric Ziegler

We present an alternative approach to pump-probe spectroscopy for measuring fast charge dynamics with an atomic force microscope (AFM). Our approach is based on coherent multifrequency lock-in measurement of the intermodulation between a…

Mesoscale and Nanoscale Physics · Physics 2019-01-30 Riccardo Borgani , David B. Haviland
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