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This white paper introduces the Weak Signal Cultivation Model (WSCM). WSCM is a human-centric framework for detecting, structuring, and tracking weak risk signals as observed by frontline staff. The model centers on a continuous [0,10] x…
The TGF-beta pathway plays a central role in tissue homeostasis and morphogenesis. It transduces a variety of extracellular signals into intracellular transcriptional responses that control a plethora of cellular processes, including cell…
Transformers have become the de facto backbone of modern deep learning, yet their training typically demands an advanced optimizer with adaptive learning rate like AdamW, rather than a momentum SGDW (mSGDW). Previous works show that it is…
Wide neural networks are biased towards learning certain functions, influencing both the rate of convergence of gradient descent (GD) and the functions that are reachable with GD in finite training time. As such, there is a great need for…
The Wnt signaling pathway plays a critical role in various biochemical processes, including embryonic development, tissue homeostasis, and cancer progression. In this paper, we conduct a comparative analysis of $\beta$-catenin-dependent Wnt…
The Circle of Willis (CoW) is the part of cerebral vasculature responsible for delivering blood to the brain. Understanding the diverse anatomical variations and configurations of the CoW is paramount to advance research on cerebrovascular…
Embryonic development is driven by spatial patterns of gene expression that determine the fate of each cell in the embryo. While gene expression is often highly erratic, embryonic development is usually exceedingly precise. In particular,…
Deep learning-based models have greatly advanced the performance of speech enhancement (SE) systems. However, two problems remain unsolved, which are closely related to model generalizability to noisy conditions: (1) mismatched noisy…
Convergence-extension in embryos is controlled by chemical and mechanical signalling. A key cellular process is the exchange of neighbours via T1 transitions. We propose and analyse a model with positive feedback between recruitment of…
Diffusion Probabilistic Models have demonstrated remarkable performance across a wide range of generative tasks. However, we have observed that these models often suffer from a Signal-to-Noise Ratio-timestep (SNR-t) bias. This bias refers…
Homeostatic mechanisms play a crucial role in maintaining optimal functionality within the neural circuits of the brain. By regulating physiological and biochemical processes, these mechanisms ensure the stability of an organism's internal…
Motivated by recent studies of symmetry protected topological (SPT) phases, we explore the possible gapless quantum disordered phases in the $(2+1)d$ nonlinear sigma model defined on the Grassmannian manifold $\frac{U(N)}{U(n)\times U(N -…
Magnetic resonance imaging (MRI) noninvasively provides critical information about how human brain structures develop across stages of life. Developmental scientists are particularly interested in the first few years of neurodevelopment.…
Quantum kernel methods are promising for near-term quantum ma- chine learning, yet their behavior under data corruption remains insuf- ficiently understood. We analyze how quantum feature constructions degrade under controlled additive…
Quantum interference is studied in a three-band model of pseudospin-one fermions in the $\alpha-\mathcal{T}_3$ lattice. We derive a general formula for magnetoconductivity that predicts a rich crossover between weak localization (WL) and…
Timely up- or down-regulation of gene expression is crucial for cellular differentiation and function. While gene upregulation via transcriptional activators has been extensively investigated, gene silencing remains understudied, especially…
Organisms are equipped with regulatory systems that display a variety of dynamical behaviours ranging from simple stable steady states, to switching and multistability, to oscillations. Earlier work has shown that oscillations in protein…
Diabetic-induced peripheral neuropathy (DPN) is a diabetic late complication. The molecular mechanisms underlying the pathophysiology of nerve damage & sensory loss remain largely unclear. Recently, alterations in metabolic flux have gained…
Suppression of excessively synchronous beta-band oscillatory activity in the brain is believed to suppress hypokinetic motor symptoms of Parkinson's disease. Recently, a lot of interest has been devoted to desynchronizing delayed feedback…
Plants depend on the signaling of the phytohormone auxin for their development and for responding to environmental perturbations. The associated biomolecular signaling network involves a negative feedback at the level of the Aux/IAA…