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We study the statistical properties of a simple genetic regulatory network that provides heterogeneity within a population of cells. This network consists of a binary genetic switch in which stochastic flipping between the two switch states…

Soft Condensed Matter · Physics 2009-03-31 Paolo Visco , Rosalind J. Allen , Martin R. Evans

Responses have been numerically studied of an ensemble of $N$ (=1, 10, and 100) Hodgkin-Huxley (HH) neurons to coherent spike-train inputs applied with independent Poisson spike-train (ST) noise and Gaussian white noise. Three interrelated…

Disordered Systems and Neural Networks · Physics 2007-05-23 Hideo Hasegawa

Information processing in the brain is conducted by a concerted action of multiple neural populations. Gaining insights in the organization and dynamics of such populations can best be studied with broadband intracranial recordings of…

The proper biological functioning of proteins often relies on the occurrence of coordinated fluctuations around their native structure, or of wider and sometimes highly elaborated motions. Coarse-grained elastic-network descriptions are…

Biomolecules · Quantitative Biology 2013-10-17 Yves Dehouck , Alexander S. Mikhailov

The constituents of a complex system exchange information to function properly. Their signalling dynamics often leads to the appearance of emergent phenomena, such as phase transitions and collective behaviors. While information exchange…

Physics and Society · Physics 2020-11-18 Arsham Ghavasieh , Carlo Nicolini , Manlio De Domenico

Stochasticity is both exploited and controlled by cells. Although the intrinsic stochasticity inherent in biochemistry is relatively well understood, cellular variation, or 'noise', is predominantly generated by interactions of the system…

Molecular Networks · Quantitative Biology 2008-09-18 Vahid Shahrezaei , Julien F Ollivier , Peter S Swain

We study a pulse-coupled dynamics of excitable elements in uncorrelated scale-free networks. Regimes of self-sustained activity are found for homogeneous and inhomogeneous couplings, in which the system displays a wide variety of behaviors,…

Neurons and Cognition · Quantitative Biology 2017-03-10 P. Piedrahita , J. J. Mazo , L. M. Floría , Y. Moreno

The field of complex networks studies a wide variety of interacting systems by representing them as networks. To understand their properties and mutual relations, the randomisation of network connections is a commonly used tool. However,…

Statistical Mechanics · Physics 2024-10-18 Noam Abadi , Franco Ruzzenenti

Finite time convergence to functionally important target states is a key component of many biological processes. We previously found that the terminal approach phase of such dynamics exhibits universal types of stochastic dynamics that…

Biological Physics · Physics 2023-04-20 Nicolas Lenner , Matthias Häring , Stephan Eule , Jörg Großhans , Fred Wolf

Relaxation dynamics of complex quantum systems with strong interactions towards the steady state is a fundamental problem in statistical mechanics. The steady state of subsystems weakly interacting with their environment is described by the…

Statistical Mechanics · Physics 2016-06-22 Alexey M. Shakirov , Yulia E. Shchadilova , Alexey N. Rubtsov

Neuronal dynamics is intrinsically unstable, producing activity fluctuations that are essentially scale-free. Here we show that while these scale-free fluctuations are independent of temporal input statistics, they can be entrained by input…

Neurons and Cognition · Quantitative Biology 2013-05-02 Asaf Gal , Shimon Marom

The dynamic range of stimulus processing in living organisms is much larger than a single neural network can explain. For a generic, tunable spiking network we derive that while the dynamic range is maximal at criticality, the interval of…

Disordered Systems and Neural Networks · Physics 2020-02-12 Johannes Zierenberg , Jens Wilting , Viola Priesemann , Anna Levina

We present collective dynamics of the Cucker-Smale (C-S) ensemble under random communications. As an effective modeling of the C-S ensemble, we introduce a stochastic kinetic C-S equation with a multiplicative white noise. For the proposed…

Analysis of PDEs · Mathematics 2019-09-04 Seung-Yeal Ha , Jinwook Jung , Michael Röckner

Predicting the response of nonlinear dynamical systems subject to random, broadband excitation is important across a range of scientific disciplines, such as structural dynamics and neuroscience. Building data-driven models requires…

Machine Learning · Computer Science 2024-09-27 Joseph Massingham , Ole Nielsen , Tore Butlin

Accurate force fields are essential for reliable molecular simulations. These models are refined against quantum mechanical calculations and experimental measurements, which are subject to random and systematic errors. Bayesian Inference of…

Chemical Physics · Physics 2025-11-04 Robert M. Raddi , Vincent A. Voelz

The theory of Balanced Neural Networks is a very popular explanation for the high degree of variability and stochasticity in the brain's activity. Roughly speaking, it entails that typical neurons receive many excitatory and inhibitory…

Probability · Mathematics 2025-05-27 James MacLaurin , Pedro Vilanova

This paper addresses the problem of estimating the modes of an observed non-stationary mixture signal in the presence of an arbitrary distributed noise. A novel Bayesian model is introduced to estimate the model parameters from the…

Signal Processing · Electrical Eng. & Systems 2022-03-31 Quentin Legros , Dominique Fourer , Sylvain Meignen , Marcelo A. Colominas

Exchangeability is a desired statistical property of network ensembles requiring their invariance upon relabelling of the nodes. However combining sparsity of network ensembles with exchangeability is challenging. Here we propose a…

Disordered Systems and Neural Networks · Physics 2022-04-14 Ginestra Bianconi

We present a new algorithm for learning unknown governing equations from trajectory data, using and ensemble of neural networks. Given samples of solutions $x(t)$ to an unknown dynamical system $\dot{x}(t)=f(t,x(t))$, we approximate the…

Machine Learning · Computer Science 2021-10-19 Elisa Negrini , Giovanna Citti , Luca Capogna

Intrinsic noise, the stochastic cell-to-cell fluctuations in mRNAs and proteins, has been observed and proved to play important roles in cellular systems. Due to the recent development in single-cell-level measurement technology, the…

Methodology · Statistics 2017-11-15 Chao Du , Wing Hong Wong