Related papers: Multiplexing Biochemical Signals
Multi-nucleated cells exist in all domains of life, ranging from animals, plants and fungi to single-celled organisms such as the slime mold Physarum polycephalum. The large cell size, in the case of Physarum reaching centimeters and more,…
This paper provides synchronization conditions for networks of nonlinear systems. The components of the network (referred to as "compartments'' in this paper) are made up of an identical interconnection of subsystems, each represented as an…
We describe a mechanism for pronounced biochemical oscillations, relevant to microscopic systems, such as the intracellular environment. This mechanism operates for reaction schemes which, when modeled using deterministic rate equations,…
This work focuses on the construction of optimized binary signaling schemes for two-sender uncoded transmission of correlated sources over non-orthogonal Gaussian multiple access channels. Specifically, signal constellations with binary…
In this paper, we introduce a mathematical approach for system-level analysis and optimization of densely deployed multiple-antenna cellular networks, where low-energy devices are capable of decoding information data and harvesting power…
Eukaryotic cells transmit information by signaling through complex networks of interacting proteins. Here we develop a theoretical and computational framework that relates the biophysics of protein-protein interactions (PPIs) within a…
How do single cell fate decisions induced by activation of key signaling proteins above threshold concentrations within a time interval are affected by stochastic fluctuations in biochemical reactions? We address this question using minimal…
Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can cells be optimally efficient, and if not, why? We show that,…
Can a micron sized sack of interacting molecules understand, and adapt to a constantly-fluctuating environment? Cellular life provides an existence proof in the affirmative, but the principles that allow for life's existence are far from…
A scheme is proposed that combines probabilistic signal shaping with bit-metric decoding. The transmitter generates symbols according to a distribution on the channel input alphabet. The symbols are labeled by bit strings. At the receiver,…
Probabilistic inference provides a language for describing how organisms may learn from and adapt to their environment. The computations needed to implement probabilistic inference often require specific representations, akin to having the…
Living cells sense noisy biochemical signals crucial for survival, yet models incorporating intracellular signaling are limited. This study examines how cells sense chemotactic concentrations through phosphorylation readouts in Ca2+…
Multiplexing services as a key communication technique to effectively combine multiple signals into one signal and transmit over a shared medium. Multiplexing can increase the channel capacity by requiring more resources on the transmission…
We study random linear network coding for broadcasting in time division duplexing channels. We assume a packet erasure channel with nodes that cannot transmit and receive information simultaneously. The sender transmits coded data packets…
We consider mutual information between release times and capture times for a set of M identical quanta traveling independently from a source to a target. The quanta are immediately captured upon arrival, first-passage times are assumed…
Due to structural and functional abnormalities or genetic variations and mutations, there may be dysfunctional molecules within an intracellular signaling network that do not allow the network to correctly regulate its output molecules,…
The possible mechanisms of communications between distant bio-systems by means of optical and UV photons are studied. It is argued that their main production mechanism is owed to the biochemical reactions, occurring during the cell…
Neurons, as eukaryotic cells, have powerful internal computation capabilities. One neuron can have many distinct states, and brains can use this capability. Processes of neuron growth and maintenance use chemical signalling between cell…
A cell has the ability to convert an environmental change into the expression of genetic information through a chain of intracellular signal transduction reactions. Here, we aimed to develop a method for quantifying this signal…
Many cellular components are present in such low numbers that individual stochastic production and degradation events lead to significant fluctuations in molecular abundances. Although feedback control can, in principle, suppress such…