Related papers: Multiplexing Biochemical Signals
Information theory provides powerful tools for understanding communication systems. This analysis can be applied to intercellular signal transduction, which is a means of chemical communication among cells and microbes. We discuss how to…
In this paper, we consider the bacterial point-to-point and multiple-access molecular communications with ligand-receptors. For the point-to-point communication, we investigate common signaling methods, namely the Level Scenario (LS), which…
Mutual information is a theoretically grounded metric for quantifying cellular signaling pathways. However, its measurement demands characterization of both input and output distributions, limiting practical applications. Here, we present…
Mounting evidence shows that oscillatory activity is widespread in cell signaling. Here we review some of this recent evidence, focusing on both the molecular mechanisms that potentially underlie such dynamical behavior, and the potential…
We have developed a coarse-grained formulation for modeling the dynamic behavior of cells quantitatively, based on stochasticity and heterogeneity, rather than on biochemical reactions. We treat each reaction as a continuous-time stochastic…
Transport of neural signals in the brain is challenging, owing to neural interference and neural noise. There is experimental evidence of multiplexing of sensory information across population of neurons, particularly in the vertebrate…
Life depends as much on the flow of information as on the flow of energy. Here we review the many efforts to make this intuition precise. Starting with the building blocks of information theory, we explore examples where it has been…
Multicellular organisms comprise a diverse collection of stable tissues built from different cell types. It remains unclear how large numbers of interacting cells can precisely coordinate their gene expression during tissue…
In this paper, we study the bidirectional/two-way relaying of molecular communication and propose a relaying scheme with two time slots. Compared to the four-time-slot and three-time-slot schemes, the proposed two-time-slot scheme improves…
Biological systems, from cells to organisms, must respond to the ever changing environment in order to survive and function. This is not a simple task given the often random nature of the signals they receive, as well as the intrinsically…
In this work, we describe the first modular, and programmable platform capable of transmitting a text message using chemical signalling -- a method also known as molecular communication. This form of communication is attractive for…
Cells measure concentrations of external ligands by capturing ligand molecules with cell surface receptors. The numbers of molecules captured by different receptors co-vary because they depend on the same extrinsic ligand fluctuations.…
The goal of this paper is to provide a rigorous information-theoretic analysis of subnetworks of interference networks. We prove two coding theorems for the compound multiple-access channel with an arbitrary number of channel states. The…
The lack of uniqueness arising by oversampling of Fourier coefficients is shown to provide a way of transmitting hidden information. A basic encoding/decoding system, developed on the basis of such a possibility, is discussed. The system is…
The evolution of multicellular organisms from monocellular ancestors represents one of the greatest advances of the history of life. The assembly of such multicellular organisms requires signalling and response between cells: over millions…
Living cells must control the reading out or "expression" of information encoded in their genomes, and this regulation often is mediated by transcription factors--proteins that bind to DNA and either enhance or repress the expression of…
This paper focuses on molecular communication (MC) systems where the signaling molecules may participate in a reversible bimolecular reaction in the channel. The motivation for studying these MC systems is that they can realize the concept…
With the completion of human genome mapping, the focus of scientists seeking to explain the biological complexity of living systems is shifting from analyzing the individual components (such as a particular gene or biochemical reaction) to…
For information transmission a binary symmetric channel is used. There is also another noisy binary symmetric channel (feedback channel), and the transmitter observes without delay all the outputs of the forward channel via that feedback…
We consider the broadcast phase of a three-node network, where a relay node establishes a bidirectional communication between two nodes using a spectrally efficient two-phase decode-and-forward protocol. In the first phase the two nodes…