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Living cells communicate information about physiological conditions by producing signaling molecules in a specific timed manner. Different conditions can result in the same total amount of a signaling molecule, differing only in the pattern…

Molecular Networks · Quantitative Biology 2018-10-09 Jackson O'Brien , Arvind Murugan

We consider a communication scenario, in which an intruder tries to determine the modulation scheme of the intercepted signal. Our aim is to minimize the accuracy of the intruder, while guaranteeing that the intended receiver can still…

Machine Learning · Computer Science 2020-04-09 Muhammad Zaid Hameed , Andras Gyorgy , Deniz Gunduz

We quantify the influence of the topology of a transcriptional regulatory network on its ability to process environmental signals. By posing the problem in terms of information theory, we may do this without specifying the function…

Molecular Networks · Quantitative Biology 2015-06-26 Etay Ziv , Ilya Nemenman , Chris H. Wiggins

Reactions forming a pathway can be rewritten by making explicit the different molecular components involved in them. A molecular component represents a biological entity (e.g. a protein) in all its states (free, bound, degraded, etc.). In…

Computational Engineering, Finance, and Science · Computer Science 2013-10-01 Andrea Maggiolo-Schettini , Paolo Milazzo , Giovanni Pardini

Designing a neural network architecture for molecular representation is crucial for AI-driven drug discovery and molecule design. In this work, we propose a new framework for molecular representation learning. Our contribution is threefold:…

Machine Learning · Computer Science 2022-10-18 Jiye Kim , Seungbeom Lee , Dongwoo Kim , Sungsoo Ahn , Jaesik Park

Molecular Communication (MC) is an important nanoscale communication paradigm, which is employed for the interconnection of the nanomachines (NMs) to form nanonetworks. A transmitter NM (TN) sends the information symbols by emitting…

Signal Processing · Electrical Eng. & Systems 2020-03-27 Baris Atakan , Fatih Gulec

Biological cells sense external chemical stimuli in their environment using cell-surface receptors. To increase the sensitivity of sensing, receptors often cluster, most noticeably in bacterial chemotaxis, a paradigm for signaling and…

Biological Physics · Physics 2015-05-27 Gerardo Aquino , Diana Clausznitzer , Sylvain Tollis , Robert G. Endres

This article examines recent research in molecular communications from a telecommunications system design perspective. In particular, it focuses on channel models and state-of-the-art physical layer techniques. The goal is to provide a…

Emerging Technologies · Computer Science 2015-07-28 Weisi Guo , Taufiq Asyhari , Nariman Farsad , H. Birkan Yilmaz , Bin Li , Andrew Eckford , Chan-Byoung Chae

Biological systems have evolved to amazingly complex states, yet we do not understand in general how evolution operates to generate increasing genetic and functional complexity. Molecular recognition sites are short genome segments or…

Populations and Evolution · Quantitative Biology 2025-01-06 Tom Röschinger , Roberto Morán Tovar , Simone Pompei , Michael Lässig

This survey paper focuses on modulation aspects of molecular communication, an emerging field focused on building biologically-inspired systems that embed data within chemical signals. The primary challenges in designing these systems are…

Emerging Technologies · Computer Science 2020-12-29 Mehmet Sukru Kuran , H. Birkan Yilmaz , Ilker Demirkol , Nariman Farsad , Andrea Goldsmith

Understanding brain function, constructing computational models and engineering neural prosthetics require assessing two problems, namely encoding and decoding, but their relation remains controversial. For decades, the encoding problem has…

Neurons and Cognition · Quantitative Biology 2017-01-16 Hugo Gabriel Eyherabide

This paper studies the mitigation of intersymbol interference in a diffusive molecular communication system using enzymes that freely diffuse in the propagation environment. The enzymes form reaction intermediates with information molecules…

Information Theory · Computer Science 2014-01-21 Adam Noel , Karen C. Cheung , Robert Schober

Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface receptors is degenerate in many systems leading to…

DNA-interacting proteins have roles multiple processes, many operating as molecular machines which undergo dynamic metastable transitions to bring about their biological function. To fully understand this molecular heterogeneity, DNA and…

Biomolecules · Quantitative Biology 2015-04-15 Adam J. M. Wollman , Helen Miller , Zhaokun Zhou , Mark C. Leake

A network of nanomachines (NMs) can be used to build a target detection system for a variety of promising applications. They have the potential to detect toxic chemicals, infectious bacteria, and biomarkers of dangerous diseases such as…

Information Theory · Computer Science 2024-01-10 Nithin V. Sabu , Abhishek K. Gupta

In many settings, such as scientific inference, optimization, and transfer learning, the learner has a well-defined objective, which can be treated as estimation of a target parameter, and no intrinsic interest in characterizing the entire…

Machine Learning · Computer Science 2025-07-23 Sabina J. Sloman , Ayush Bharti , Julien Martinelli , Samuel Kaski

We show that combining vibrational spectroscopy with signal processing can result in a scheme for ultrasensitive detection of molecules. We consider the vibrational spectrum as a signal on the energy axis and apply a matched filter on that…

Computational Physics · Physics 2018-12-10 Tay Yong Boon , Ian Tay Rongde , Loy Liang Yi , Aw Ke Fun , Ong Zhi Li , Sergei Manzhos

Electronic warfare support (ES) systems intercept adversary radar signals and estimate various types of signal information, including modulation schemes. The accurate and rapid identification of modulation schemes under conditions of very…

Signal Processing · Electrical Eng. & Systems 2025-05-15 Do-Hyun Park , Min-Wook Jeon , Jinwoo Jeong , Isaac Sim , Sangbom Yun , Junghyun Seo , Hyoung-Nam Kim

In recent years, machine learning has been adopted to complex networks, but most existing works concern about the structural properties. To use machine learning to detect phase transitions and accurately identify the critical transition…

Physics and Society · Physics 2020-01-08 Qi Ni , Ming Tang , Ying Liu , Ying-Cheng Lai

In this paper, we design matched filters for diffusive molecular communication systems taking into account the following impairments: signal-dependent diffusion noise, inter-symbol interference (ISI), and external interfering molecules. The…

Information Theory · Computer Science 2017-05-05 Vahid Jamali , Arman Ahmadzadeh , Robert Schober
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