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Molecular recognition, which is essential in processing information in biological systems, takes place in a crowded noisy biochemical environment and requires the recognition of a specific target within a background of various similar…

Biomolecules · Quantitative Biology 2010-07-27 Yonatan Savir , Tsvi Tlusty

To perform recognition, molecules must locate and specifically bind their targets within a noisy biochemical environment with many look-alikes. Molecular recognition processes, especially the induced-fit mechanism, are known to involve…

Biomolecules · Quantitative Biology 2010-07-27 Yonatan Savir , Tsvi Tlusty

The specificity of molecular recognition is important to molecular self-organization. A prominent example is the biological cell where, within a highly crowded molecular environment, a myriad of different molecular receptor pairs recognize…

Chemical Physics · Physics 2020-09-07 Marc Schenkelberger , Christian Trapp , Timo Mai , Albrecht Ott

Achieving precise synchronisation between transmitters and receivers is particularly challenging in diffusive molecular communication environments. To this end, point-to-point molecular communication system design is examined wherein…

Signal Processing · Electrical Eng. & Systems 2018-11-09 Tze-Yang Tung , Urbashi Mitra

Cells receive signaling molecules by receptors and relay information via sensory networks so that they can respond properly depending on the type of signal. Recent studies have shown that cells can extract multi-dimensional information from…

Biological Physics · Physics 2018-02-14 Yoshihiko Hasegawa

Molecular communication is a novel approach for data transmission between miniaturized devices, especially in contexts where electrical signals are to be avoided. The communication is based on sending molecules (or other particles) at nano…

Emerging Technologies · Computer Science 2023-08-08 Max Bartunik , Jens Kirchner , Oliver Keszocze

Information transmission in biological signaling circuits has often been described using the metaphor of a noise filter. Cellular systems need accurate, real-time data about their environmental conditions, but the biochemical reaction…

Molecular Networks · Quantitative Biology 2019-02-27 David Hathcock , James Sheehy , Casey Weisenberger , Efe Ilker , Michael Hinczewski

We consider a molecular communication system comprised of a transmitter, an absorbing receiver, and an interference source. Assuming amplitude modulation, we analyze the dependence of the bit error rate (BER) on the detection interval,…

Information Theory · Computer Science 2020-05-05 Trang Ngoc Cao , Nikola Zlatanov , Phee Lep Yeoh , Jamie S. Evans

Molecular Communications (MC) is a bio-inspired communication technique that uses molecules to transfer information among bio-nano devices. In this paper, we focus on the detection problem for biological MC receivers employing ligand…

Emerging Technologies · Computer Science 2021-05-13 Murat Kuscu , Ozgur B. Akan

Symbol synchronization refers to the estimation of the start of a symbol interval and is needed for reliable detection. In this paper, we develop several symbol synchronization schemes for molecular communication (MC) systems where we…

Information Theory · Computer Science 2017-09-05 Vahid Jamali , Arman Ahmadzadeh , Robert Schober

Life relies on the efficient performance of molecular codes, which relate symbols and meanings via error-prone molecular recognition. We describe how optimizing a code to withstand the impact of molecular recognition noise may be…

Quantitative Methods · Quantitative Biology 2010-07-26 Tsvi Tlusty

The network inference problem arises in biological research when one needs to quantitatively choose the best protein-interaction model for explaining a phenotype. The diverse nature of the data and nonlinear dynamics pose significant…

Molecular Networks · Quantitative Biology 2025-12-22 Guy Karlebach

In molecular communications, the direct detection of signaling molecules may be challenging due to a lack of suitable sensors and interference in the environment. Motivated by research in molecular biology, we investigate an indirect…

Information Theory · Computer Science 2022-04-25 Trang Ngoc Cao , Vahid Jamali , Wayan Wicke , Phee Lep Yeoh , Nikola Zlatanov , Jamie S Evans , Robert Schober

In a diffusion-based molecular communication network, transmitters and receivers communicate by using signalling molecules (or ligands) in a fluid medium. This paper assumes that the transmitter uses different chemical reactions to generate…

Information Theory · Computer Science 2019-04-25 Chun Tung Chou

Symbol synchronization refers to the estimation of the start of a symbol interval and is needed for reliable detection. In this paper, we develop a symbol synchronization framework for molecular communication (MC) systems where we consider…

Information Theory · Computer Science 2017-02-24 Vahid Jamali , Arman Ahmadzadeh , Robert Schober

Generating a novel and optimized molecule with desired chemical properties is an essential part of the drug discovery process. Failure to meet one of the required properties can frequently lead to failure in a clinical test which is costly.…

Machine Learning · Computer Science 2020-10-28 Bonggun Shin , Sungsoo Park , JinYeong Bak , Joyce C. Ho

In this paper, we propose a novel design for molecular communication in which both the transmitter and the receiver have, in a 3-dimensional environment, multiple bulges (in RF communication this corresponds to antenna). The proposed system…

Emerging Technologies · Computer Science 2016-11-17 Bonhong Koo , H. Birkan Yilmaz , Andrew Eckford , Chan-Byoung Chae

We study non-coherent detection schemes for molecular communication (MC) systems that do not require knowledge of the channel state information (CSI). In particular, we first derive the optimal maximum likelihood (ML) multiple-symbol (MS)…

Information Theory · Computer Science 2017-07-28 Vahid Jamali , Nariman Farsad , Robert Schober , Andrea Goldsmith

The process of dynamic state estimation (filtering) based on point process observations is in general intractable. Numerical sampling techniques are often practically useful, but lead to limited conceptual insight about optimal…

Machine Learning · Statistics 2016-09-13 Yuval Harel , Ron Meir , Manfred Opper

The problem of designing optimal quantization rules for sequential detectors is investigated. First, it is shown that this task can be solved within the general framework of active sequential detection. Using this approach, the optimal…

Information Theory · Computer Science 2021-07-29 Michael Fauß , Manuel S. Stein , H. Vincent Poor
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