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This paper focuses on molecular communication (MC) systems using two types of signaling molecules which may participate in a reversible bimolecular reaction in the channel. The motivation for studying these MC systems is that they can…

Information Theory · Computer Science 2019-07-25 Vahid Jamali , Nariman Farsad , Robert Schober , Andrea Goldsmith

Biological systems display impressive capabilities in effectively responding to environmental signals in real time. There is increasing evidence that organisms may indeed be employing near optimal Bayesian calculations in their…

Neurons and Cognition · Quantitative Biology 2010-02-12 Steve Yaeli , Ron Meir

This paper proposes a latent prompt Transformer model for solving challenging optimization problems such as molecule design, where the goal is to find molecules with optimal values of a target chemical or biological property that can be…

Machine Learning · Computer Science 2024-02-07 Deqian Kong , Yuhao Huang , Jianwen Xie , Ying Nian Wu

Automatic Chemical Design is a framework for generating novel molecules with optimized properties. The original scheme, featuring Bayesian optimization over the latent space of a variational autoencoder, suffers from the pathology that it…

Machine Learning · Statistics 2019-08-13 Ryan-Rhys Griffiths , José Miguel Hernández-Lobato

A random sequence having two segments being the homogeneous Markov processes is registered. Each segment has his own transition probability law and the length of the segment is unknown and random. The transition probabilities of each…

Statistics Theory · Mathematics 2020-11-17 A. Ochman-Gozdek , W. Sarnowski , K. J. Szajowski

We consider a Bayesian persuasion or information design problem where the sender tries to persuade the receiver to take a particular action via a sequence of signals. This we model by considering multi-phase trials with different…

Theoretical Economics · Economics 2021-11-24 Shih-Tang Su , Vijay G. Subramanian , Grant Schoenebeck

Neural decoding may be formulated as dynamic state estimation (filtering) based on point process observations, a generally intractable problem. Numerical sampling techniques are often practically useful for the decoding of real neural data.…

Neurons and Cognition · Quantitative Biology 2019-01-15 Yuval Harel , Ron Meir , Manfred Opper

There are many problems in biochemistry that are difficult to study experimentally. Simulation methods are appealing due to direct availability of atomic coordinates as a function of time. However, direct molecular simulations are…

Biomolecules · Quantitative Biology 2023-05-24 Malin Luking , David van der Spoel , Johan Elf , Gareth A. Tribello

Spectrum sensing is of critical importance in any cognitive radio system. When the primary user's signal has uncertain parameters, the likelihood ratio test, which is the theoretically optimal detector, generally has no closed-form…

Signal Processing · Electrical Eng. & Systems 2019-08-07 Ziyu Ye , Qihang Peng , Kelly Levick , Hui Rong , Andrew Gilman , Pamela Cosman , Larry Milstein

Engineering biology requires precise control of biomolecular circuits, and Cybergenetics is the field dedicated to achieving this goal. A significant challenge in developing controllers for cellular functions is designing systems that can…

Quantitative Methods · Quantitative Biology 2024-09-18 Hamza Faquir , Manuel Pájaro , Irene Otero-Muras

The function of the organism hinges on the performance of its information-processing networks, which convey information via molecular recognition. Many paths within these networks utilize molecular codebooks, such as the genetic code, to…

Biomolecules · Quantitative Biology 2010-07-27 Tsvi Tlusty

In a molecular communication network, transmitters and receivers communicate by using signalling molecules. At the receivers, the signalling molecules react, via a chain of chemical reactions, to produce output molecules. The counts of…

Molecular Networks · Quantitative Biology 2020-07-23 Chun Tung Chou

In many signal processing applications, including communications, sonar, radar, and localization, a fundamental problem is the detection of a signal of interest in background noise, known as signal detection [1] [2]. A simple version of…

Signal Processing · Electrical Eng. & Systems 2025-12-16 Tom Anders , Hiten Prakash Kothari , R. Michael Buehrer

This paper considers a diffusion-based molecular communication system where the transmitter uses Reaction Shift Keying (RSK) as the modulation scheme. We focus on the demodulation of RSK signal at the receiver. The receiver consists of a…

Information Theory · Computer Science 2019-04-25 Hamdan Awan , Chun Tung Chou

Optimizing chemical molecules for desired properties lies at the core of drug development. Despite initial successes made by deep generative models and reinforcement learning methods, these methods were mostly limited by the requirement of…

Machine Learning · Computer Science 2021-12-01 Shuangjia Zheng , Ying Song , Zhang Pan , Chengtao Li , Le Song , Yuedong Yang

Signal recognition is a spectrum sensing problem that jointly requires detection, localization in time and frequency, and classification. This is a step beyond most spectrum sensing work which involves signal detection to estimate "present"…

Signal Processing · Electrical Eng. & Systems 2021-10-04 Nathan West , Timothy O'Shea , Tamoghna Roy

Anomaly detection is a well-established field in machine learning, identifying observations that deviate from typical patterns. The principles of anomaly detection could enhance our understanding of how biological systems recognize and…

Populations and Evolution · Quantitative Biology 2025-10-30 Steven A. Frank

Any organism is embedded in an environment that changes over time. The timescale for and statistics of environmental change, the precision with which the organism can detect its environment, and the costs and benefits of particular protein…

Quantitative Methods · Quantitative Biology 2023-07-19 David A. Sivak , Matt Thomson

The problem of environmental monitoring using a wireless network of chemical sensors with a limited energy supply is considered. Since the conventional chemical sensors in active mode consume vast amounts of energy, an optimisation problem…

Social and Information Networks · Computer Science 2011-11-07 Alex Skvortsov , Branko Ristic

In this paper, we perform receiver design for a diffusive molecular communication environment. Our model includes flow in any direction, sources of information molecules in addition to the transmitter, and enzymes in the propagation…

Information Theory · Computer Science 2014-10-17 Adam Noel , Karen C. Cheung , Robert Schober