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We investigate the phenomenon of protein induced tubulation of lipid bilayer membranes within a continuum framework using Monte Carlo simulations coupled with the Widom insertion technique to compute excess chemical potentials. Tubular…

Biological Physics · Physics 2015-10-13 Richard W. Tourdot , N. Ramakrishnan , Tobias Baumgart , Ravi Radhakrishnan

We investigate the dynamics of a phase-separating binary fluid, containing colloidal dumbbells anchored to the fluid-fluid interface. Extensive Lattice Boltzmann-Immersed Boundary method simulations reveal that the presence of soft…

Soft Condensed Matter · Physics 2022-01-20 A. Tiribocchi , F. Bonaccorso , M. Lauricella , S. Melchionna , A. Montessori , S. Succi

Conical inclusions in a lipid bilayer generate an overall spontaneous curvature of the membrane that depends on concentration and geometry of the inclusions. Examples are integral and attached membrane proteins, viruses, and lipid domains.…

Soft Condensed Matter · Physics 2009-10-19 Thorsten Auth , Gerhard Gompper

We show that inversion-asymmetric tethered membranes exhibit a new double-spiral phase with long range orientational order not present in symmetric membranes. We calculate the universal algebraic spiral shapes of these membranes in this…

Statistical Mechanics · Physics 2019-06-05 Tirthankar Banerjee , Niladri Sarkar , John Toner , Abhik Basu

Lipid bilayers forming biological membranes are known to behave as viscous 2D fluids on submicrometer scales; usually they contain a large number of active protein inclusions. Recently, it has been shown [Proc. Nat. Acad. Sci. USA 112,…

Soft Condensed Matter · Physics 2016-08-31 Yuki Koyano , Hiroyuki Kitahata , Alexander S. Mikhailov

We numerically study an anisotropic shape transformation of membranes under external forces for two-dimensional triangulated surfaces on the basis of Finsler geometry. The Finsler metric is defined by using a vector field, which is the…

Soft Condensed Matter · Physics 2016-03-08 Hiroshi Koibuchi , Andrey Shobukhov

The dynamical response of a lipid membrane to a local perturbation of its molecular symmetry is investigated theoretically. A density asymmetry between the two membrane leaflets is predominantly released by in-plane lipid diffusion or…

Soft Condensed Matter · Physics 2009-11-10 Pierre Sens

Flat sheets encoded with patterns of contraction/elongation morph into curved surfaces. If the surfaces bear Gauss curvature, the resulting actuation can be strong and powerful. We deploy the Gauss-Bonnet theorem to deduce the Gauss…

Soft Condensed Matter · Physics 2021-07-01 Daniel Duffy , John S. Biggins

Cell adhesion proteins are transmembrane proteins that bind cells to their environment. These proteins typically cluster into disk-shaped or linear structures. Here we show that such clustering patterns spontaneously emerge when the protein…

Soft Condensed Matter · Physics 2023-07-10 Shao-Zhen Lin , Rishita Changede , Michael P. Sheetz , Jacques Prost , Jean-Francois Rupprecht

Osmotic deflation of vesicles enclosing two liquid phases can lead to bulging of one of the phases from the vesicle body. This budding process is preceded by a complete to partial wetting transition of one of the liquid phases on the…

Soft Condensed Matter · Physics 2012-01-17 Yanhong Li , Halim Kusumaatmaja , Reinhard Lipowsky , Rumiana Dimova

Biomolecular condensates are formed via liquid-liquid phase separation of proteins, often together with nucleic acids, typically driven by interactions between low-affinity binding sites. The computational study of such condensates that…

Soft Condensed Matter · Physics 2025-01-16 Alena Taskina , Devika Magan , Simon Dannenberg , Stefan Klumpp

We experimentally explore the morphological evolution of cages in quasi-two-dimensional suspensions of colloidal fluids, uncovering a complex dynamic restructuring in the fluid. Although cages display isotropic evolution in the laboratory…

Soft Condensed Matter · Physics 2024-08-13 Noman Hanif Barbhuiya , Chandan K. Mishra

We present a method for simulating fluid vesicles with in-plane orientational ordering. The method involves computation of local curvature tensor and parallel transport of the orientational field on a randomly triangulated surface. It is…

Biological Physics · Physics 2015-05-18 N. Ramakrishnan , P. B. Sunil Kumar , John H. Ipsen

Graphene is a powerful membrane prototype for both applications and fundamental research. Rheological phenomena including indentation, twisting, and wrinkling in deposited and suspended graphene are actively investigated to unravel the…

Membranes are an important subject of study in physical chemistry and biology. They can be considered as material surfaces with a surface energy depending on the curvature tensor. Usually, mathematical models developed in the literature…

Classical Physics · Physics 2019-08-14 Sergey Gavrilyuk , Henri Gouin

We construct a model to explore the hydrodynamic interactions of active inclusions in curved biological membranes. The curved membrane is modelled as a two dimensional layer of highly viscous fluid, surrounded by external solvents of…

Soft Condensed Matter · Physics 2025-06-23 Sarthak Bagaria , Rickmoy Samanta

We have studied the pearling instability induced on hollow tubular lipid vesicles by hydrophilic polymers with hydrophobic side groups along the backbone. The results show that the polymer concentration is coupled to local membrane…

Biological membranes mainly consist of lipids and proteins. While the proteins have many functions as single molecules, the membrane as a whole displays physical properties that cannot be explained on the single molecule level. For example,…

Biological Physics · Physics 2009-06-09 Thomas Heimburg

The Bin/amphiphysin/Rvs (BAR) superfamily proteins have a crescent binding domain and bend biomembranes along the domain axis. However, their anisotropic bending rigidities and spontaneous curvatures have not been experimentally determined.…

Soft Condensed Matter · Physics 2023-07-28 Hiroshi Noguchi , Nikhil Walani , Marino Arroyo

A continuum electromechanical model is proposed to describe the membrane curvature induced by electrostatic interactions in a solvated protein-membrane system. The model couples the macroscopic strain energy of membrane and the…

Quantitative Methods · Quantitative Biology 2015-05-19 Y. C. Zhou , Benzhuo Lu , Alemayehu A. Gorfe