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Motivated by the importance of optical microscopes to science and engineering, scientists have pondered for centuries how to improve their resolution and the existence of fundamental resolution limits. In recent years, a new class of…

Quantum Physics · Physics 2015-07-28 Mankei Tsang

The wave-particle duality of light introduces two fundamental problems to imaging, namely, the diffraction limit and the photon shot noise. Quantum information theory can tackle them both in one holistic formalism: model the light as a…

Quantum Physics · Physics 2020-04-10 Mankei Tsang

A simple optical lens plays an important role for exploring the microscopic world in science and technology by refracting light with tailored spatially varying refractive index. Recent advancements in nanotechnology enable novel lenses,…

Optics · Physics 2014-11-25 Jianjun Cao , Ce Shang , Yuanlin Zheng , Xianfeng Chen , Xiaogan Liang , Wenjie Wan

Microscopy is the workhorse of the physical and life sciences, producing crisp images of everything from atoms to cells well beyond the capabilities of the human eye. However, the analysis of these images is frequently little better than…

Soft Condensed Matter · Physics 2017-10-18 Matthew Bierbaum , Brian D. Leahy , Alexander A. Alemi , Itai Cohen , James P. Sethna

Super-resolution imaging refers to imaging techniques that surpass the Rayleigh resolution limit. One standard way to achieve super-resolution is by structuring the phase of the field illuminating the object. Although super-resolution…

Applied Physics · Physics 2025-11-13 Nilakshi Senapati , Abhinandan Bhattacharjee , Kedar Khare , Anand K Jha

Most methods for optical visualization beyond the diffraction limit rely on fluorescence emission by molecular tags. Here, we report a method for visualization of nanostructures down to a few nanometers using a conventional bright-field…

Nonlinear optical microscopy allows rapid high-resolution microscopy with image contrast generated from intrinsic properties of the sample. Established modalities such as multiphoton excited fluorescence and second/third-harmonic generation…

Optical sensing is one of the key-enablers of modern diagnostics. Especially label-free imaging modalities hold great promise as they eliminate labeling procedures prior to analysis. However, scattering signals of nanometric particles scale…

Optics · Physics 2021-02-03 Unai Ortiz-Orruño , Ala Jo , Hakho Lee , Niek F. van Hulst , Matz Liebel

Infrared (IR) imaging has become a viable tool for visualizing various chemical bonds in a specimen. The performance, however, is limited in terms of spatial resolution and imaging speed. Here, instead of measuring the loss of the IR beam,…

Optics · Physics 2018-11-20 Yeran Bai , Delong Zhang , Lu Lan , Yimin Huang , Kerry Maize , Ali Shakouri , Ji-Xin Cheng

The ultimate sensitivity of optical measurements is a key element of many recent works. Classically, it is mainly limited by the shot noise limit. However, a measurement setup that incorporates quantum mechanical principles can surpass the…

Quantum Physics · Physics 2013-11-13 L. Cohen , D. Istrati , L. Dovrat , H. S. Eisenberg

Far-field chemical microscopy providing molecular electronic or vibrational fingerprint information opens a new window for the study of three-dimensional biological, material, and chemical systems. Chemical microscopy provides a…

Optics · Physics 2023-06-06 Mingwei Tang , Yubing Han , Danchen Jia , Qing Yang , Ji-Xin Cheng

We introduce MINFLUX, a concept for localizing photon emitters in space. By probing the emitter with a local intensity minimum of excitation light, MINFLUX minimizes the fluorescence photons needed for high localization precision. A 22-fold…

Optical hyperspectral imaging based on absorption and scattering of photons at the visible and adjacent frequencies denotes one of the most informative and inclusive characterization methods in material research. Unfortunately, restricted…

An ideal imaging system provides a spatial resolution that is ultimately dictated by the numerical aperture (NA) of the illumination and collection optics. In biological tissue, resolution is further affected by scattering limiting the…

A microscope based on the Linnik interferometer was designed, built, and tested. Two methods were used for interference pattern measurement: phase-shifting and polarized single-shot methods. The former uses a low coherence light emitting…

Optics · Physics 2024-06-25 Sergei V. Anishchik , Marcos Dantus

The evaluation and monitoring of cells health in the human retina is crucial and follow time course of retinal diseases, detect lesions before irreversible visual loss and to evaluate treatment effects. Towards this goal, a major challenge…

Far-field optical microscopy using focused light is an important tool in a number of scientific disciplines including chemical, (bio)physical and biomedical research, particularly with respect to the study of living cells and organisms.…

We propose and numerically demonstrate a technique for subwavelength imaging based on a metal-dielectric multilayer hyperlens designed in such a way that only the large-wavevector waves are transmitted while all propagating waves from the…

Optics · Physics 2015-10-28 Taavi Repän , Andrei V. Lavrinenko , Sergei V. Zhukovsky

Essentially, the idea of improving the resolution of a given imaging system is to enhance its information capacity represented usually by the temporal-bandwidth (or, spatial-spectrum) product. This letter introduces the concept of…

Optics · Physics 2014-03-21 Lianlin Li , Fang Li , Tiejun Cui