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We investigate the influence of polymer-pore interactions on the translocation dynamics using Langevin dynamics simulations. An attractive interaction can greatly improve translocation probability. At the same time, it also increases…

Soft Condensed Matter · Physics 2007-10-01 Kaifu Luo , Tapio Ala-Nissila , See-chen Ying , Aniket Bhattacharya

We study unbiased translocation of a flexible polymer chain through a membrane pore under the influence of active noise and steric exclusion using Langevin dynamics simulations. The active noise is incorporated by introducing nonchiral and…

Soft Condensed Matter · Physics 2022-07-19 Zahra Fazli , Ali Naji

Finite-size scaling arguments naturally lead us to introduce a coordinate-dependent diffusion coefficient in a Fokker-Planck description of the late stage dynamics of unbiased polymer translocation through a membrane pore. The solution for…

Statistical Mechanics · Physics 2015-06-17 Giovanni Brandani , Fulvio Baldovin , Enzo Orlandini , Attilio L. Stella

A Markov state model is a powerful tool that can be used to track the evolution of populations of configurations in an atomistic representation of a protein. For a coarse-grained linear chain model with discontinuous interactions, the…

Soft Condensed Matter · Physics 2024-02-06 Margarita Colberg , Jeremy Schofield

While the characteristics of the driven translocation for asymptotically long polymers are well understood, this is not the case for finite-sized polymers, which are relevant for real-world experiments and simulation studies. Most notably,…

Biological Physics · Physics 2017-12-18 P. M. Suhonen , K. Kaski , R. P. Linna

We perform two-dimensional Langevin dynamics simulations of electric-field driven polymer translocation through an attractive nanopore. We investigate the effect of the location of the attractive region using different pore patterns. This…

Soft Condensed Matter · Physics 2015-06-15 F Piguet , D P Foster

We study the translocation of polymers across varying-section channels. Using systematic approximations, we derive a simplified model that reduces the problem of polymer translocation through varying-section channels to that of a point-like…

Soft Condensed Matter · Physics 2017-07-13 Valentino Bianco , Paolo Malgaretti

We derive the stochastic equations of motion for a tracer that is tightly attached to a semiflexible polymer and confined or agitated by an externally controlled potential. The generalised Langevin equation, the power spectrum, and the…

Soft Condensed Matter · Physics 2011-11-22 Jakob Tómas Bullerjahn , Sebastian Sturm , Lars Wolff , Klaus Kroy

Polymer ejection from a capsid through a nanoscale pore is an important biological process with relevance to modern biotechnology. Here, we study generic capsid ejection using Langevin dynamics. We show that even when the ejection takes…

Biological Physics · Physics 2014-05-09 R. P. Linna , J. E. Moisio , P. M. Suhonen , K. Kaski

The concepts of probability, statistics and stochastic theory are being successfully used in structural engineering. Markov Chain modelling is a simple stochastic process model that has found its application in both describing stochastic…

Applications · Statistics 2007-08-14 K. Balaji Rao

We present results from our simulations of biopolymer translocation in a solvent which explain the main experimental findings. The forced translocation can be described by simple force balance arguments for the relevant range of pore…

Biological Physics · Physics 2009-05-08 V. V. Lehtola , R. P. Linna , K. Kaski

Markov Chains with variable length are useful stochastic models for data compression that avoid the curse of dimensionality faced by that full Markov Chains. In this paper we introduce a Variable Length Markov Chain whose transition…

Methodology · Statistics 2020-01-01 Adriano Zanin Zambom , Seonjin Kim , Nancy Lopes Garcia

We study the driven translocation of a flexible polymer through an interacting conical pore using Langevin dynamics simulations. We find that, for a fixed value of externally applied force and pore polymer interaction strength, the mean…

Soft Condensed Matter · Physics 2021-02-17 Rajneesh Kumar , Abhishek Chaudhuri , Rajeev Kapri

By analyzing the real space nonequilibrium dynamics of polymers, we elucidate the physics of driven translocation and propose its dynamical scaling scenario analogous to that in the surface growth phenomena. We provide a detailed account of…

Soft Condensed Matter · Physics 2011-11-28 Takuya Saito , Takahiro Sakaue

Using analytical techniques and Langevin dynamics simulations, we investigate the dynamics of polymer translocation into a narrow channel of width $R$ embedded in two dimensions, driven by a force proportional to the number of monomers in…

Soft Condensed Matter · Physics 2011-08-26 Kaifu Luo , Ralf Metzler

We present results of statistical analysis of solar wind turbulence using an approach based on the theory of Markov processes. It is shown that the Chapman-Kolmogorov equation is approximately satisfied for the turbulent cascade. We…

Plasma Physics · Physics 2009-11-13 Marek Strumik , Wieslaw M. Macek

We examine the phase transition of polymer adsorption as well as the underlying kinetics of polymer binding from dilute solutions on a structureless solid surface. The emphasis is put on the properties of regular multiblock copolymers,…

Soft Condensed Matter · Physics 2009-09-03 A. Milchev , V. Rostiashvili , S. Bhattacharya , T. Vilgis

Using molecular dynamics simulations we examine the dynamics of a family of model polymers with varying chain length and torsional potential barriers. We focus on features of the dynamics of polymers that are seen experimentally but absent…

Soft Condensed Matter · Physics 2019-06-11 Daniel Fragiadakis , C. Michael Roland

Numerical results on the translocation of long biopolymers through mid-sized and wide pores are presented. The simulations are based on a novel methodology which couples molecular motion to a mesoscopic fluid solvent. Thousands of events of…

Biological Physics · Physics 2015-05-13 Maria Fyta , Simone Melchionna , Massimo Bernaschi , Efthimios Kaxiras , Sauro Succi

We develop a general theory of Markov chains realizable as random walks on $\mathscr R$-trivial monoids. It provides explicit and simple formulas for the eigenvalues of the transition matrix, for multiplicities of the eigenvalues via…

Combinatorics · Mathematics 2015-03-30 Arvind Ayyer , Anne Schilling , Benjamin Steinberg , Nicolas M. Thiery