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Liquid-liquid phase separation is key to understanding aqueous two-phase systems (ATPS) arising throughout cell biology, medical science, and the pharmaceutical industry. Controlling the detailed morphology of phase-separating compound…

Soft Condensed Matter · Physics 2023-10-27 Eric W. Hester , Sean P. Carney , Vishwesh Shah , Alyssa Arnheim , Bena Patel , Dino Di Carlo , Andrea L. Bertozzi

We present a new and efficient phase-field solver for viscoelastic fluids with moving contact line based on a dual-resolution strategy. The interface between two immiscible fluids is tracked by using the Cahn-Hilliard phase-field model, and…

Fluid Dynamics · Physics 2022-09-27 Kazem Bazesefidpar , Luca Brandt , Outi Tammisola

Liposome vesicles tend to align with an applied magnetic field. This is due to the directional magnetic susceptibility difference of the lipids which form the membrane of these vesicles. In this work a model of liposome vesicles exposed to…

Soft Condensed Matter · Physics 2016-08-22 David Salac

Biomolecules, such as proteins and RNAs, can phase separate in the cytoplasm of cells to form biomolecular condensates. Such condensates are liquid-like droplets that can wet biological surfaces such as membranes. Many molecules that…

Soft Condensed Matter · Physics 2024-09-04 Xueping Zhao , Susanne Liese , Alf Honigmann , Frank Jülicher , Christoph A. Weber

The dynamics of a membrane is a coupled system comprising a moving elastic surface and an incompressible membrane fluid. We will consider a reduced elastic surface model, which involves the evolution equations of the moving surface, the…

Analysis of PDEs · Mathematics 2015-05-27 Wei Wang , Pingwen Zhang , Zhifei Zhang

In this paper we present approaches that address two issues that can occur when the level-set method is used to simulate two-fluid flows in engineering practice. The first issue concerns regularizing the Heaviside function on arbitrary…

Numerical Analysis · Mathematics 2018-02-02 Ido Akkerman

This paper discusses a relation between the re-initialization equation of the level-set functions derived by Wac{\l}awczyk [J.Comp.Phys., 299, (2015)] and the condition for the phase equilibrium provided by the stationary solution to the…

Fluid Dynamics · Physics 2018-02-13 Tomasz Wacławczyk

Motivated by a long-standing debate concerning the nature and interrelations of surface-tension variables in fluid membranes, we reformulate the thermodynamics of a membrane vesicle as a generic two-dimensional finite system enclosing a…

Soft Condensed Matter · Physics 2012-02-03 Haim Diamant

We present a new method for the geometric reconstruction of elastic surfaces simulated by the immersed boundary method with the goal of simulating the motion and interactions of cells in whole blood. Our method uses parameter-free radial…

Numerical Analysis · Mathematics 2022-08-31 Andrew Kassen , Aaron Barrett , Varun Shankar , Aaron L. Fogelson

Despite the wide existence of vesicles in living cells as well as their important applications like drug-delivery, the underlying mechanism of vesicle fusion/fission remains under debate. Here, we develop a constrained self-consistent field…

Soft Condensed Matter · Physics 2023-05-22 Luofu Liu , Chao Duan , Rui Wang

In many interfacial flow systems, variations of surface properties lead to novel and interesting behaviors. In this work a three-dimensional model of flow dynamics for multicomponent vesicles is presented. The surface composition is modeled…

Soft Condensed Matter · Physics 2017-12-07 Prerna Gera , David Salac

Lipid bilayer membranes are the fundamental biological barriers that permit life. The bilayer dynamics largely participates in orchestrating cellular workings and is characterized by substantial stability together with extreme plasticity…

Soft Condensed Matter · Physics 2022-12-05 Matteo Bottacchiari , Mirko Gallo , Marco Bussoletti , Carlo Massimo Casciola

Biological membranes and vesicles play a central role in living systems, forming dynamic interfaces that regulate cellular organization and function. Classical descriptions of membrane mechanics that are rooted in equilibrium statistical…

Soft Condensed Matter · Physics 2026-02-24 Sreekanth Ramesh , Prashant K. Purohit , Yashashree Kulkarni

Phase-field methods have long been used to model the flow of immiscible fluids. Their ability to naturally capture interface topological changes is widely recognized, but their accuracy in simulating flows of real fluids in practical…

Fluid Dynamics · Physics 2019-06-10 Baofang Song , Carlos Plana , Jose M. Lopez , Marc Avila

We present an hybrid VOF/embedded boundary method allowing to model two-phase flows in presence of solids with arbitrary shapes. The method relies on the coupling of existing methods: a geometric Volume of fluid (VOF) method to tackle the…

Dynamics of a single vesicle under shear flow between two parallel plates is studied using two-dimensional lattice-Boltzmann simulations. We first present how we adapted the lattice-Boltzmann method to simulate vesicle dynamics, using an…

Soft Condensed Matter · Physics 2011-09-16 Badr Kaoui , Jens Harting , Chaouqi Misbah

The study of vesicles in suspension is important to understand the complicated dynamics exhibited by cells in vivo and in vitro. We developed a computer simulation based on the boundary-integral method to model the three dimensional…

Biological Physics · Physics 2013-07-24 Ivan Rey Suarez , Chad Leidy , Gabriel Tellez , Guillaume Gay , Andres Gonzalez-Mancera

We present a phase field model for vesicle growth or shrinkage induced by an osmotic pressure due to a chemical potential gradient. The model consists of an Allen-Cahn equation describing the evolution of phase field and a Cahn-Hilliard…

Numerical Analysis · Mathematics 2022-09-29 Xiaoxia Tang , Shuwang Li , John S. Lowengrub , Steven M. Wise

Many interfacial phenomena in physical and biological systems are dominated by high order geometric quantities such as curvature. Here a semi-implicit method is combined with a level set jet scheme to handle stiff nonlinear advection…

Numerical Analysis · Mathematics 2016-08-22 Guhan Velmurugan , Ebrahim M. Kolahdouz , David Salac

We simulate the mesoscopic dynamics of droplets formed by phase separated fluids at nanometer scales where thermal fluctuations are significant. Both spherical droplets fully immersed in a second fluid and sessile droplets which are also in…

Fluid Dynamics · Physics 2024-11-18 John B. Bell , Andrew Nonaka , Alejandro L. Garcia