English

Phase field modeling and computation of vesicle growth or shrinkage

Numerical Analysis 2022-09-29 v1 Numerical Analysis

Abstract

We present a phase field model for vesicle growth or shrinkage induced by an osmotic pressure due to a chemical potential gradient. The model consists of an Allen-Cahn equation describing the evolution of phase field and a Cahn-Hilliard equation describing the evolution of concentration field. We establish control conditions for vesicle growth or shrinkage via a common tangent construction. During the membrane deformation, the model ensures total mass conservation and satisfies surface area constraint. We develop a nonlinear numerical scheme, a combination of nonlinear Gauss-Seidel relaxation operator and a V-cycles multigrid solver, for computing equilibrium shapes of a 2D vesicle. Convergence tests confirm an O(t+h2)\mathcal{O}(t+h^2) accuracy. Numerical results reveal that the diffuse interface model captures the main feature of dynamics: for a growing vesicle, there exist circle-like equilibrium shapes if the concentration difference across the membrane and the initial osmotic pressure are large enough; while for a shrinking vesicle, there exists a rich collection of finger-like equilibrium morphologies.

Keywords

Cite

@article{arxiv.2209.13690,
  title  = {Phase field modeling and computation of vesicle growth or shrinkage},
  author = {Xiaoxia Tang and Shuwang Li and John S. Lowengrub and Steven M. Wise},
  journal= {arXiv preprint arXiv:2209.13690},
  year   = {2022}
}