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The widely used model for evolutionary relationships is a bifurcating tree with all taxa/observations placed at the leaves. This is not appropriate if the taxa have been densely sampled across evolutionary time and may be in a direct…

Populations and Evolution · Quantitative Biology 2017-01-12 Prabhav Kalaghatgi , Nico Pfeifer , Thomas Lengauer

We propose a Block Majorization Minimization method with Extrapolation (BMMe) for solving a class of multi-convex optimization problems. The extrapolation parameters of BMMe are updated using a novel adaptive update rule. By showing that…

Machine Learning · Computer Science 2025-09-03 Le Thi Khanh Hien , Valentin Leplat , Nicolas Gillis

Matching datasets of multiple modalities has become an important task in data analysis. Existing methods often rely on the embedding and transformation of each single modality without utilizing any correspondence information, which often…

Machine Learning · Statistics 2024-06-27 Cencheng Shen , Joshua T. Vogelstein , Carey E. Priebe

Many popular algorithms for searching the space of leaf-labelled trees are based on tree rearrangement operations. Under any such operation, the problem is reduced to searching a graph where vertices are trees and (undirected) edges are…

Data Structures and Algorithms · Computer Science 2020-07-27 Lena Collienne , Alex Gavryushkin

A variety of algorithms have been proposed for reconstructing trees that show the evolutionary relationships between species by comparing differences in genetic data across present-day taxa. If the leaf-to-leaf distances in a tree can be…

Populations and Evolution · Quantitative Biology 2014-11-18 Olivier Gascuel , Mike Steel

In this article the results of Waddell and Azad (2009) are extended. In particular, the geometric percentage mean standard deviation measure of the fit of distances to a phylogenetic tree is adjusted for the number of parameters fitted to…

Populations and Evolution · Quantitative Biology 2011-01-04 Peter J. Waddell , Ariful Azad , Ishita Khan

A protein contact map is a binary symmetric adjacency matrix capturing the distance relationship between atoms of a protein. Each cell (i, j) of a protein contact map states whether the atoms (nodes) i and j are within some Euclidean…

Molecular Networks · Quantitative Biology 2013-05-07 Susan Khor

The elusive nature of gradient-based optimization in neural networks is tied to their loss landscape geometry, which is poorly understood. However recent work has brought solid evidence that there is essentially no loss barrier between the…

Machine Learning · Statistics 2023-10-17 Simone Rossi , Ankit Singh , Thomas Hannagan

A recurring theme in the least squares approach to phylogenetics has been the discovery of elegant combinatorial formulas for the least squares estimates of edge lengths. These formulas have proved useful for the development of efficient…

Combinatorics · Mathematics 2009-11-13 Radu Mihaescu , Lior Pachter

The optimal mixing evolutionary algorithms (OMEAs) have recently drawn much attention for their robustness, small size of required population, and efficiency in terms of number of function evaluations (NFE). In this paper, the performances…

Neural and Evolutionary Computing · Computer Science 2018-07-30 Yu-Fan Tung , Tian-Li Yu

In this paper, we propose an ensemble learning algorithm called \textit{under-bagging $k$-nearest neighbors} (\textit{under-bagging $k$-NN}) for imbalanced classification problems. On the theoretical side, by developing a new learning…

Machine Learning · Statistics 2021-09-03 Hanyuan Hang , Yuchao Cai , Hanfang Yang , Zhouchen Lin

Phylogenetic trees are leaf-labelled trees used to model the evolution of species. In practice it is not uncommon to obtain two topologically distinct trees for the same set of species, and this motivates the use of distance measures to…

Data Structures and Algorithms · Computer Science 2026-03-24 David Mestel , Steven Chaplick , Steven Kelk , Ruben Meuwese

The reassembling of a simple connected graph G = (V,E) is an abstraction of a problem arising in earlier studies of network analysis. The reassembling process has a simple formulation (there are several equivalent formulations) relative to…

Computational Complexity · Computer Science 2016-02-10 Saber Mirzaei , Assaf Kfoury

The problem of reconstructing evolutionary trees or phylogenies is of great interest in computational biology. A popular model for this problem assumes that we are given the set of leaves (current species) of an unknown binary tree and the…

Data Structures and Algorithms · Computer Science 2022-06-16 Eshwar Ram Arunachaleswaran , Anindya De , Sampath Kannan

Bayesian Networks (BNs) are of interest from an explainable AI viewpoint, offering transparent probabilistic models for decision support. Baymex is a recently introduced multi-objective evolutionary algorithm for learning discretized BNs,…

Machine Learning · Computer Science 2026-05-29 Damy M. F. Ha , Tanja Alderliesten , Peter A. N. Bosman

Neural architecture search (NAS) remains a challenging problem, which is attributed to the indispensable and time-consuming component of performance estimation (PE). In this paper, we provide a novel yet systematic rethinking of PE in a…

Computer Vision and Pattern Recognition · Computer Science 2020-05-21 Xiawu Zheng , Rongrong Ji , Qiang Wang , Qixiang Ye , Zhenguo Li , Yonghong Tian , Qi Tian

Accurate estimation of evolutionary distances between taxa is important for many phylogenetic reconstruction methods. In the case of bacteria, distances can be estimated using a range of different evolutionary models, from single nucleotide…

Populations and Evolution · Quantitative Biology 2017-04-17 Stuart Serdoz , Attila Egri-Nagy , Jeremy Sumner , Barbara R. Holland , Peter D. Jarvis , Mark M. Tanaka , Andrew R. Francis

The study of genetic map linearization leads to a combinatorial hard problem, called the {\em minimum breakpoint linearization} (MBL) problem. It is aimed at finding a linearization of a partial order which attains the minimum breakpoint…

Genomics · Quantitative Biology 2015-02-26 Xin Chen

We consider the reconciliation problem, in which the task is to find a mapping of a gene tree into a species tree, so as to maximize the likelihood of such fitting, given the available data. We describe a model for the evolution of the…

Populations and Evolution · Quantitative Biology 2023-11-09 Albert C. Soewongsono , Jiahao Diao , Tristan Stark , Amanda E. Wilson , David A. Liberles , Barbara R. Holland , Malgorzata M. O'Reilly

Multi-party multi-objective optimization problems (MPMOPs) require consensus among autonomous decision makers and therefore differ from flattened many-objective formulations. Existing runtime theory for multi-objective evolutionary…

Artificial Intelligence · Computer Science 2026-05-19 Xiaolei Fang , Peilan Xu , Wenjian Luo