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In this paper, we consider an optimal control problem for a prescription opioid epidemic model that describes the interaction between the regular prescription or addictive use of opioid drugs, and the process of rehabilitation and that of…

Optimization and Control · Mathematics 2018-12-11 Getachew K. Befekadu

We investigate the expected time to extinction in the susceptible-infectious-susceptible (SIS) model of disease spreading. Rather than using stochastic simulations, or asymptotic calculations in network models, we solve the extinction time…

Populations and Evolution · Quantitative Biology 2018-12-26 Petter Holme , Liubov Tupikina

We study classical stochastic systems with discrete states, coupled to switching external environments. For fast environmental processes we derive reduced dynamics for the system itself, focusing on corrections to the adiabatic limit of…

Statistical Mechanics · Physics 2019-03-27 Peter G. Hufton , Yen Ting Lin , Tobias Galla

We study the non-equilibrium phase transition between survival and extinction of spatially extended biological populations using an agent-based model. We especially focus on the effects of global temporal fluctuations of the environmental…

Statistical Mechanics · Physics 2017-07-04 Hatem Barghathi , Skye Tackkett , Thomas Vojta

We study an ancient problem that in a static or dynamical system, sought an optimal path, which the context always means within an extremal condition. In fact, through those discussions about this theme, we established a universal essential…

Data Structures and Algorithms · Computer Science 2016-02-09 Yong Tan

This paper presents new sufficient conditions for convergence and asymptotic or exponential stability of a stochastic discrete-time system, under which the constructed Lyapunov function always decreases in expectation along the system's…

Systems and Control · Computer Science 2019-06-05 Yuzhen Qin , Ming Cao , Brian D. O. Anderson

Population genetics struggles to model extinction; standard models track the relative rather than absolute fitness of genotypes, while the exceptions describe only the short-term transition from imminent doom to evolutionary rescue. But…

Populations and Evolution · Quantitative Biology 2017-02-20 Jason Bertram , Kevin Gomez , Joanna Masel

Epidemics have shaped human history, often with devastating consequences, motivating the development of mathematical models to understand and control their dynamics. Among the many aspects of epidemic behavior, the conditions that lead to…

Populations and Evolution · Quantitative Biology 2026-05-01 Germano Hartmann Brill , Pablo Enrique Jurado Silvestrin , Sebastian Gonçalves

We demonstrate the possibility to systematically steer the most probable escape paths (MPEPs) by adjusting relative noise intensities in dynamical systems that exhibit noise-induced escape from a metastable point via a saddle point. Using a…

Statistical Mechanics · Physics 2015-06-19 Paul H. Dannenberg , John C. Neu , Stephen W. Teitsworth

Populations of replicating entities frequently experience sudden or cyclical changes in environment. We explore the implications of this phenomenon via a environmental switching parameter in several common evolutionary dynamics models…

Dynamical Systems · Mathematics 2013-06-12 Marc Harper , Dashiell Fryer , Andrew Vlasic

We present a model for evolution and extinction in large ecosystems. The model incorporates the effects of interactions between species and the influences of abiotic environmental factors. We study the properties of the model by approximate…

adap-org · Physics 2008-02-03 Bruce W. Roberts , M. E. J. Newman

We analyze ecological systems that are influenced by random environmental fluctuations. We first provide general conditions which ensure that the species coexist and the system converges to a unique invariant probability measure (stationary…

Populations and Evolution · Quantitative Biology 2021-05-19 Alexandru Hening , Yao Li

This paper proposes an approach to mitigate epidemic spread in a population of strategic agents by encouraging safer behaviors through carefully designed rewards. These rewards, which adapt to the evolving state of the epidemic, are…

Systems and Control · Electrical Eng. & Systems 2024-12-31 Shinkyu Park , Jair Certorio , Nuno C. Martins , Richard J. La

We give an explicit formula for the most likely path to extinction for the Galton-Watson processes with large initial population. We establish this result with the help of the large deviation principle (LDP) which also recovers the…

Probability · Mathematics 2007-05-23 F. Klebaner , R. Liptser

We investigate a model for spatial epidemics explicitly taking into account bi-directional movements between base and destination locations on individual mobility networks. We provide a systematic analysis of generic dynamical features of…

Physics and Society · Physics 2012-03-07 Vitaly Belik , Theo Geisel , Dirk Brockmann

Spatially explicit models have been widely used in today's mathematical ecology and epidemiology to study persistence and extinction of populations as well as their spatial patterns. Here we extend the earlier work--static dispersal between…

Populations and Evolution · Quantitative Biology 2009-07-01 Quan-Xing Liu , Rong-Hua Wang , Zhen Jin

Our paper computationally explores the extinction dynamics of an animal species effected by a sudden spike in mortality due to an extreme event. In our study, the animal species has a 2-year life cycle and is endowed with a high survival…

Quantitative Methods · Quantitative Biology 2007-05-23 Sukanto Bhattacharya , Sreepurna Malakar

Perfect adaptation in a dynamical system is the phenomenon that one or more variables have an initial transient response to a persistent change in an external stimulus but revert to their original value as the system converges to…

Artificial Intelligence · Computer Science 2023-02-27 Tineke Blom , Joris M. Mooij

We consider continuous state branching processes (CSBP) with additional multiplicative jumps modeling dramatic events in a random environment. These jumps are described by a L\'evy process with bounded variation paths. We construct a…

Probability · Mathematics 2013-12-17 Vincent Bansaye , Juan Carlos Pardo Millan , Charline Smadi

In complex systems, the interplay between nonlinear and stochastic dynamics, e.g., J. Monod's necessity and chance, gives rise to an evolutionary process in Darwinian sense, in terms of discrete jumps among attractors, with punctuated…

Adaptation and Self-Organizing Systems · Physics 2013-03-18 Hong Qian