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Processing large complex networks recently attracted considerable interest. Complex graphs are useful in a wide range of applications from technological networks to biological systems like the human brain. Sometimes these networks are…

Data Structures and Algorithms · Computer Science 2019-12-03 Christian Schulz

Motivation: High-throughput experimental techniques have been producing more and more protein-protein interaction (PPI) data. PPI network alignment greatly benefits the understanding of evolutionary relationship among species, helps…

Data Structures and Algorithms · Computer Science 2016-04-13 Somaye Hashemifar , Qixing Huang , Jinbo XU

We observe a network scenario where parts of a secret are distributed among its nodes. Within the network, a group of attackers is actively trying to obtain the complete secret, while there is also the issue of some nodes malfunctioning or…

Combinatorics · Mathematics 2023-10-10 Tanja Vojkovic , Damir Vukicevic

Infections depend on interactions between pathogen and host proteins, but comprehensively mapping these interactions is challenging and labor intensive. Many biological networks have hierarchical, scale-free structure, so we developed a…

Molecular Networks · Quantitative Biology 2025-11-19 Xiaoqiong Xia , Cesar de la Fuente-Nunez

Deep learning approaches achieved significant progress in predicting protein structures. These methods are often applied to protein-protein interactions (PPIs) yet require Multiple Sequence Alignment (MSA) which is unavailable for various…

Machine Learning · Computer Science 2024-06-27 Matan Halfon , Tomer Cohen , Raanan Fattal , Dina Schneidman-Duhovny

Graph coloring is fundamental to distributed computing. We give the first sub-logarithmic distributed algorithm for coloring cluster graphs. These graphs are obtained from the underlying communication network by contracting nodes and edges,…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-06-17 Maxime Flin , Magnus M. Halldorsson , Alexandre Nolin

We propose a new approach for defining and searching clusters in graphs that represent real technological or transaction networks. In contrast to the standard way of finding dense parts of a graph, we concentrate on the structure of edges…

Combinatorics · Mathematics 2021-03-16 András London , Ryan R. Martin , András Pluhár

Graphs may be used to represent many different problem domains -- a concrete example is that of detecting communities in social networks, which are represented as graphs. With big data and more sophisticated applications becoming widespread…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-04-03 Miguel E. Coimbra , Alexandre P. Francisco , Luis Veiga

Biological and cellular systems are often modeled as graphs in which vertices represent objects of interest (genes, proteins, drugs) and edges represent relational ties among these objects (binds-to, interacts-with, regulates). This…

Machine Learning · Statistics 2017-03-16 Jose Lugo-Martinez , Predrag Radivojac

Biomedical networks (or graphs) are universal descriptors for systems of interacting elements, from molecular interactions and disease co-morbidity to healthcare systems and scientific knowledge. Advances in artificial intelligence,…

Machine Learning · Computer Science 2025-02-07 Michelle M. Li , Kexin Huang , Marinka Zitnik

Graph coloring involves assigning colors to the vertices of a graph such that two vertices linked by an edge receive different colors. Graph coloring problems are general models that are very useful to formulate many relevant applications…

Machine Learning · Computer Science 2020-10-27 Olivier Goudet , Béatrice Duval , Jin-Kao Hao

Graphs have a superior ability to represent relational data, like chemical compounds, proteins, and social networks. Hence, graph-level learning, which takes a set of graphs as input, has been applied to many tasks including comparison,…

Machine Learning · Computer Science 2023-05-26 Zhenyu Yang , Ge Zhang , Jia Wu , Jian Yang , Quan Z. Sheng , Shan Xue , Chuan Zhou , Charu Aggarwal , Hao Peng , Wenbin Hu , Edwin Hancock , Pietro Liò

The analysis of the dynamics on complex networks is closely connected to structural features of the networks. Features like, for instance, graph-cores and node degrees have been studied ubiquitously. Here we introduce the D-spectrum of a…

Combinatorics · Mathematics 2019-12-17 Ricky X. F. Chen , Christian M. Reidys , Andrei C. Bura

Deep learning-based computational methods have achieved promising results in predicting protein-protein interactions (PPIs). However, existing benchmarks predominantly focus on isolated pairwise evaluations, overlooking a model's capability…

Machine Learning · Computer Science 2025-10-23 Xinzhe Zheng , Hao Du , Fanding Xu , Jinzhe Li , Zhiyuan Liu , Wenkang Wang , Tao Chen , Wanli Ouyang , Stan Z. Li , Yan Lu , Nanqing Dong , Yang Zhang

Complexes of physically interacting proteins constitute fundamental functional units responsible for driving biological processes within cells. A faithful reconstruction of the entire set of complexes is therefore essential to understand…

Molecular Networks · Quantitative Biology 2015-05-21 Sriganesh Srihari , Chern Han Yong , Ashwini Patil , Limsoon Wong

We model the evolution of eukaryotic protein-protein interaction (PPI) networks. In our model, PPI networks evolve by two known biological mechanisms: (1) Gene duplication, which is followed by rapid diversification of duplicate…

Molecular Networks · Quantitative Biology 2015-01-07 Jack Peterson , Steve Presse , Kristin S. Peterson , Ken A. Dill

Interaction networks are of central importance in post-genomic molecular biology, with increasing amounts of data becoming available by high-throughput methods. Examples are gene regulatory networks or protein interaction maps. The main…

Statistical Mechanics · Physics 2009-11-10 Johannes Berg , Michael Lässig

Cellular functions are based on the complex interplay of proteins, therefore the structure and dynamics of these protein-protein interaction (PPI) networks are the key to the functional understanding of cells. In the last years, large-scale…

Molecular Networks · Quantitative Biology 2013-03-27 Yuliang Jin , Dmitrij Turaev , Thomas Weinmaier , Thomas Rattei , Hernan A. Makse

A mixed graph contains (undirected) edges as well as (directed) arcs, thus generalizing undirected and directed graphs. A proper coloring $c$ of a mixed graph $G$ assigns a positive integer to each vertex such that $c(u)\neq c(v)$ for every…

Computational Complexity · Computer Science 2026-05-01 Antonio Lauerbach , Konstanty Junosza-Szaniawski , Marie Diana Sieper , Alexander Wolff

DP-coloring (also called correspondence coloring) of graphs is a generalization of list coloring that has been widely studied since its introduction by Dvo\v{r}\'{a}k and Postle in $2015$. Intuitively, DP-coloring generalizes list coloring…

Combinatorics · Mathematics 2025-02-11 Anton Bernshteyn , Daniel Dominik , Hemanshu Kaul , Jeffrey A. Mudrock
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