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An activated process consists of energy activation and barrier crossing; the former is a prerequisite for the latter. Barrier crossing has been studied extensively, but energy activation has been overlooked due to a lack of means to gauge…

Biological Physics · Physics 2020-07-31 Shanshan Wu , Ao Ma

The quasi-molecular mechanism of recombination, recently suggested by Kereselidze et al., is a non-standard process where an electron and two neighboring protons in the early universe directly form an ionized hydrogen molecule in a highly…

Cosmology and Nongalactic Astrophysics · Physics 2022-04-26 Zhiqi Huang

The ability of water to dissolve biomolecules is crucial for our life. It has been shown that protein has a profound effect on the behavior of water in its hydration shell, which in turn affects the structure and function of the protein.…

Soft Condensed Matter · Physics 2022-08-26 Rui Shi

DNA-interacting proteins have roles multiple processes, many operating as molecular machines which undergo dynamic metastable transitions to bring about their biological function. To fully understand this molecular heterogeneity, DNA and…

Biomolecules · Quantitative Biology 2015-04-15 Adam J. M. Wollman , Helen Miller , Zhaokun Zhou , Mark C. Leake

The zero point kinetic energy of protons in water is large on the scale of chemical interaction energies(29 Kj/mol in bulk room temperature water). Its value depends upon the structure of the hydrogen bond network, and can change as the…

Chemical Physics · Physics 2015-05-18 G. F. Reiter , R. Senesi , J. Mayers

Organization and maintenance of the chromosomal DNA in living cells strongly depends on the DNA interactions with a plethora of DNA-binding proteins. Single-molecule studies show that formation of nucleoprotein complexes on DNA by such…

Biomolecules · Quantitative Biology 2018-09-05 Artem K. Efremov , Jie Yan

Protein conformational changes are activated processes essential for protein functions. Activation in a protein differs from activation in a small molecule in that it involves directed and systematic energy flows through preferred channels…

Biological Physics · Physics 2020-07-15 Huiyu Li , Ao Ma

The spectrum of atomic hydrogen has long been viewed as a Rosetta stone that bears the key to decode the writings of quantum mechanics in a vast variety of physical, chemical, and biological systems. Here, we show that, in addition to its…

Unlike their model membrane counterparts, biological membranes are richly decorated with a heterogeneous assembly of membrane proteins. These proteins are so tightly packed that their excluded area interactions can alter the free energy…

Biological Physics · Physics 2017-08-23 Martin Lindén , Pierre Sens , Rob Phillips

The vacuum cavity mode induces a potential barrier and a well when an ultra-slow excited atom enters the interaction region so that it can be reflected or transmitted with a certain probability. We demonstrate here that a slow-velocity…

Quantum Physics · Physics 2009-11-13 Mihai A. Macovei

The nuclear interaction is responsible for keeping neutrons and protons joined in an atomic nucleus. Phenomenological nuclear potentials, fitted to experimental data, allow one to know about the nuclear behaviour with more or less success…

Nuclear Theory · Physics 2008-05-26 I. Casinos

The most important function of proteins may well be to bind to other biomolecules. It has long been felt that kinetic rates of bond formation and dissociation between soluble receptors and ligands might account for most features of the…

Biological Physics · Physics 2008-09-12 Anne Pierres , Joana Vitte , Anne-Marie Benoliel , Pierre Bongrand

Hydrogen peroxide oxidises cysteine residues to control protein function, yet bulk rate constants predict hours for changes that occur in cells in seconds. Here, this work shows that local electromagnetic fields (EMFs), ubiquitous in…

Biomolecules · Quantitative Biology 2025-10-29 James N. Cobley

Recent years have shown steady progress in research towards molecular electronics [1,2], where molecules have been investigated as switches [3-5], diodes [6], and electronic mixers [7]. In much of the previous work a Scanning Tunnelling…

Mesoscale and Nanoscale Physics · Physics 2009-11-07 R. H. M. Smit , Y. Noat , C. Untiedt , N. D. Lang , M. van Hemert , J. M. van Ruitenbeek

We consider excitation of highly charged hydrogen-like ions by the impact of equivelocity electrons and protons. The kinetic energy of the protons is more than three orders of magnitude larger than that of the equivelocity electrons. It is…

Atomic Physics · Physics 2015-06-15 B. Najjari , A. B. Voitkiv

Behaviours of hydrogen, such as fluidity and metallicity, are crucial for our understanding of planetary interiors and the emerging field of high-temperature superconducting hydrides. These behaviours were discovered in complex phase…

While the thermodynamics of DNA hybridization is well understood, much less is known about the kinetics of this classic system. Filling this gap in our understanding has new urgency because DNA nanotechnology often depends critically on…

Soft Condensed Matter · Physics 2013-10-28 Thomas E. Ouldridge , Petr Šulc , Flavio Romano , Jonathan P. K. Doye , Ard A. Louis

A single water molecule has nothing special. However, macroscopic water displays many anomalous properties at the interface, such as a high surface tension, hydrophobicity and hydrophillicity. Although the underlying mechanism is still…

Materials Science · Physics 2016-03-15 Wei Hu , Zhenyu Li , Jinlong Yang

The interface between a liquid and a solid is the location of plethora of intrincate mechanisms at the nanoscale, at the root of their specific emerging properties in natural processes or technological applications. However, while the…

Biological molecular machines are proteins that operate under isothermal conditions hence are referred to as free energy transducers. They can be formally considered as enzymes that simultaneously catalyze two chemical reactions: the free…

Biological Physics · Physics 2014-02-05 Michal Kurzynski , Mieczyslaw Torchala , Przemyslaw Chelminiak