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DNA self-assembly is an important tool that has a wide range of applications such as building nanostructures, the transport of target virotherapies, and nano-circuitry. Tools from graph theory can be used to encode the biological process of…

Combinatorics · Mathematics 2023-10-09 Cory Johnson , Andrew Lavengood-Ryan

Tile assembly systems in the abstract Tile Assembly Model (aTAM) are computationally universal and capable of building complex shapes, but DNA-based implementations encounter formidable error rates that stifle this theoretical potential.…

Computational Geometry · Computer Science 2024-05-13 Phillip Drake , Daniel Hader , Matthew J. Patitz

Recent advancements in microbiology have motivated the study of the production of nanostructures with applications such as biomedical computing and molecular robotics. One way to construct these structures is to construct branched DNA…

Branched molecules of deoxyribonucleic acid (DNA) can self-assemble into nanostructures through complementary cohesive strand base pairing. The production of DNA nanostructures is valuable in targeted drug delivery and biomolecular…

Combinatorics · Mathematics 2022-03-15 D. Chloe Griffin , Jessica Sorrells

We propose a mathematical model of DNA self-assembly using 2D tiles to form 3D nanostructures. This is the first work to combine studies in self-assembly and nanotechnology in 3D, just as Rothemund and Winfree did in the 2D case. Our model…

Computational Complexity · Computer Science 2007-05-23 Ming-Yang Kao , Vijay Ramachandran

Local feature matching aims at establishing sparse correspondences between a pair of images. Recently, detector-free methods present generally better performance but are not satisfactory in image pairs with large scale differences. In this…

Computer Vision and Pattern Recognition · Computer Science 2024-01-24 Junjie Ni , Yijin Li , Zhaoyang Huang , Hongsheng Li , Hujun Bao , Zhaopeng Cui , Guofeng Zhang

Within biology, it is of interest to construct DNA complexes of a certain shape. These complexes can be represented through graph theory, using edges to model strands of DNA joined at junctions, represented by vertices. Because guided…

Harnessing the intrinsic dynamics of physical systems for information processing opens new avenues for computation embodied in matter. Using simulations of a model system, we show that assemblies of DNA tiles capable of self-organizing into…

Soft Condensed Matter · Physics 2025-10-23 Tim E. Veenstra , René van Roij , Marjolein Dijkstra

Branched junction molecule assembly of DNA nanostructures, pioneered by Seeman's laboratory in the 1980s, has become increasingly sophisticated, as have the assembly targets. A critical design step is finding minimal sets of branched…

Combinatorics · Mathematics 2021-08-03 Leyda Almodóvar , Jo Ellis-Monaghan , Amanda Harsy , Cory Johnson , Jessica Sorrells

This project mathematically models the self-assembly of DNA nanostructures in the shape of select Archimedean graphs using the flexible tile model. Under three different sets of restrictions called scenarios, we employ principles of linear…

Biomolecules · Quantitative Biology 2025-04-04 Tabitha Merrithew , Jessica Sorrells

Patterned self-assembly is a process whereby coloured tiles self-assemble to build a rectangular coloured pattern. We propose self-assembly (SA) hypergraph automata as an automata-theoretic model for patterned self-assembly. We investigate…

Discrete Mathematics · Computer Science 2013-02-13 Lila Kari , Steffen Kopecki , Amirhossein Simjour

Self-assembly is ubiquitous in nature, particularly in biology, where it underlies the formation of protein quaternary structure and protein aggregation. Quaternary structure assembles deterministically and performs a wide range of…

Emerging Technologies · Computer Science 2016-04-27 S. Tesoro , S. E. Ahnert

We investigate the role of nondeterminism in Winfree's abstract Tile Assembly Model (aTAM), which was conceived to model artificial molecular self-assembling systems constructed from DNA. Of particular practical importance is to find tile…

Computational Complexity · Computer Science 2010-11-29 Nathaniel Bryans , Ehsan Chiniforooshan , David Doty , Lila Kari , Shinnosuke Seki

Self-assembly is a fundamental process by which supramolecular species form spontaneously from their components. This process is ubiquitous throughout the life chemistry and is central to biological information processing. Algorithms for…

Emerging Technologies · Computer Science 2012-07-06 Abhishek Chhajer , Manish K. Gupta , Sandeep Vasani , Jaley Dholakiya

The design of irregular planar phased arrays (PAs) characterized by a highly-modular architecture is addressed. By exploiting the property of self-replicating tile shapes, also known as rep-tiles, the arising array layouts consist of tiles…

Signal Processing · Electrical Eng. & Systems 2023-04-19 Nicola Anselmi , Luca Tosi , Paolo Rocca , Giovanni Toso , Andrea Massa

Patchy colloids are promising candidates for building blocks in directed self-assembly. To be successful the surface patterns need to both be simple enough to be synthesized, while feature-rich enough to cause the colloids to self-assemble…

Soft Condensed Matter · Physics 2014-05-13 Erik Edlund , Oskar Lindgren , Martin Nilsson Jacobi

Recent advances enable the creation of nanoscale building blocks with complex geometries and interaction specificities for self-assembly. This nearly boundless design space necessitates design principles for defining the mutual interactions…

Soft Condensed Matter · Physics 2024-03-29 Daichi Hayakawa , Thomas E. Videbæk , Gregory M. Grason , W. Benjamin Rogers

In this paper we present a model containing modifications to the Signal-passing Tile Assembly Model (STAM), a tile-based self-assembly model whose tiles are capable of activating and deactivating glues based on the binding of other glues.…

Emerging Technologies · Computer Science 2022-03-30 Andrew Alseth , Daniel Hader , Matthew J. Patitz

The process of self-assembly is guided by the minimization of free energy, which limits the symmetries available for assembly and ultimately the usefulness of devices fabricated in this fashion. Here, we demonstrate experimentally for the…

DNA Self-Assembly has emerged as an interdisciplinary field with many intriguing applications such DNA bio-sensor, DNA circuits, DNA storage, drug delivery etc. Tile assembly model of DNA has been studied for various computational…

Emerging Technologies · Computer Science 2015-02-20 Shalin Shah , Parth Dave , Manish K Gupta