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Cells deploy robust mechanisms to repair DNA damage, safeguarding genomic stability and cellular health, but the physical principles underlying these processes remain incompletely understood. Experiments show \emph{in vitro} that upon a DNA…

Biological Physics · Physics 2026-05-26 Rakesh Das , Tarun Mascarenhas , Nagaraja Chappidi , Simon Alberti , Frank Jülicher

A methodology for the statistical mechanical analysis of polymeric chains under tension introduced previously is extended to include torque. The response of individual bonds between monomers or of entire groups of monomers to a combination…

Soft Condensed Matter · Physics 2022-06-15 Aaron C. Meyer , Michael Karbach , Ping Lu , Gerhard Müller

We use a recently developed coarse-grained model for DNA to study kissing complexes formed by hybridization of complementary hairpin loops. The binding of the loops is topologically constrained because their linking number must remain…

Soft Condensed Matter · Physics 2012-12-24 Flavio Romano , Alex Hudson , Jonathan P. K. Doye , Thomas E. Ouldridge , Ard A. Louis

We study a model for pair interaction $U$ of DNA molecules generated by the discrete dipole moments of base-pairs and the charges of phosphate groups, and find noncommutative group of eighth order ${\cal S}$ of symmetries that leave $U$…

Soft Condensed Matter · Physics 2009-11-13 Voislav Golo , Efim Kats , Yuriy Volkov

The energy conversion of oxygenic photosynthesis is triggered by primary charge separation in proteins at the photosystem II reaction center. Here, we investigate the impacts of the protein environment and intramolecular vibrations on…

Chemical Physics · Physics 2018-08-23 Yuta Fujihashi , Masahiro Higashi , Akihito Ishizaki

Microscopy observations show that suspensions of synthetic and natural nano-layered smectite clay particles submitted to a strong external electric field undergo a fast and extended structuring. This structuring results from the interaction…

Soft Condensed Matter · Physics 2009-11-11 J. O. Fossum , Y. Meheust , K. P. S. Parmar , K. D. Knudsen , K. J. Maloy , D. M. Fonseca

The Exact Factorization (XF) of molecular wavefunctions can be viewed as an 'electronic wavepacket' framework for quantum dynamics. It is an appealing alternative to the conventional non-adiabatic dynamics, unfolding in the space of coupled…

Chemical Physics · Physics 2025-10-10 Julian Stetzler , Sophya Garashchuk , Vitaly A. Rassolov

The spontaneous localization mechanism of collapse models induces a Brownian motion in all physical systems. This effect is very weak, but experimental progress in creating ultracold atomic systems can be used to detect it. In this paper,…

Quantum Physics · Physics 2016-08-12 Marco Bilardello , Sandro Donadi , Andrea Vinante , Angelo Bassi

Proteins must fold quickly to acquire their biologically functional three-dimensional native structures. Hence, these are mainly stabilized by local contacts, while intricate topologies such as knots are rare. Here, we reveal the existence…

Biomolecules · Quantitative Biology 2019-06-20 Marco Baiesi , Enzo Orlandini , Flavio Seno , Antonio Trovato

We show that spontaneous density segregation in dense systems of aligning circle swimmers is a condensation phenomenon at odds with the phase separation scenarios usually observed in two-dimensional active matter. The condensates, which…

Soft Condensed Matter · Physics 2024-12-20 Yujia Wang , Bruno Ventéjou , Hugues Chaté , Xia-qing Shi

This work addresses the question of the interplay of DNA demixing and supercoiling in bacterial cells. Demixing of DNA from other globular macromolecules results from the overall repulsion between all components of the system and leads to…

Biological Physics · Physics 2020-08-14 Marc Joyeux

The function of protein, RNA, and DNA is modulated by fast, dynamic exchanges between three-dimensional conformations. Conformational sampling of biomolecules with exact and nullspace inverse kinematics, using rotatable bonds as revolute…

Robotics · Computer Science 2016-07-27 Rasmus Fonseca , Dominik Budday , Henry van den Bedem

Chirality-induced spin selectivity is a spin-splitting phenomenon from a helical structure with a considerably effective spin-orbit coupling. This unexpectedly large spin-splitting phenomenon has been experimentally observed in chiral…

Strongly Correlated Electrons · Physics 2024-05-08 Meng Xu , Yan Chen

This article presents a physical biology approach to understanding organization and segregation of bacterial chromosomes. The author uses a "piston" analogy for bacterial chromosomes in a cell, which leads to a phase diagram for the…

Subcellular Processes · Quantitative Biology 2010-06-01 Suckjoon Jun

The structure and dynamics of negatively charged nucleic acids strongly correlate with the concentration and charge of the oppositely charged counter-ions. It is well known that the structural collapse of DNA is favored in the presence of…

Soft Condensed Matter · Physics 2015-08-24 Soumadwip Ghosh , Himanshu Dixit , Rajarshi Chakrabarti

We perform simulations of a system containing simple model proteins and a polymer representing chromatin. We study the interplay between protein-protein and protein-chromatin interactions, and the resulting condensates which arise due to…

Soft Condensed Matter · Physics 2022-07-20 Marco Ancona , Chris A. Brackley

Positions of protons in DNA hydrogen bonds are fundamental for the fidelity of the replication process. Because the hydrogen bond is partially covalent the electronic structure of DNA plays an important role in the replication process.…

Strongly Correlated Electrons · Physics 2007-05-23 Chun-Min Chang , A. H. Castro Neto , A. R. Bishop

We initiate a holographic study of coupling-dependent heavy ion collisions by analysing for the first time the effects of leading-order, inverse coupling constant corrections. In the dual description, this amounts to colliding gravitational…

High Energy Physics - Theory · Physics 2017-07-20 Sašo Grozdanov , Wilke van der Schee

We address a molecular dissociation mechanism that is known to occur when a H 2 molecule approaches a catalyst with its molecular axis parallel to the surface. It is found that molecular dissociation is a form of quantum dynamical phase…

Chemical Physics · Physics 2016-05-31 Andres Ruderman , Axel Dente , Elizabeth Santos , Horacio Miguel Pastawski

Spontaneous parametric down-conversion is a vital method for generating correlated photon pairs in the visible and near-infrared spectral regions; however, its extension to X-ray frequencies has faced substantial barriers. Here, we present…

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