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All cells must keep time to consistently perform vital biological functions. To that end, the coupling and interrelatedness of diverse subsecond events in the complex cellular environment, such as protein folding or translation rates,…

Subcellular Processes · Quantitative Biology 2012-10-02 Sepehr Ehsani

Cell motility is one of the most fundamental phenomena underlying biological processes that maintain living organisms alive. Here we introduce a simple model to describe the motility of cells which include not only time-correlated internal…

Biological Physics · Physics 2022-07-13 T. N. Azevedo , L. G. Rizzi

Membrane computing is a well-established and successful research field which belongs to the more general area of molecular computing. Membrane computing aims at defining parallel and non-deterministic computing models, called membrane…

Distributed, Parallel, and Cluster Computing · Computer Science 2011-08-11 Bogdan Aman

Living systems exhibit a range of fundamental characteristics: they are active, self-referential, self-modifying systems. This paper explores how these characteristics create challenges for conventional scientific approaches and why they…

Emerging Technologies · Computer Science 2025-08-18 Samson Abramsky , Wolfgang Banzhaf , Leo S. D. Caves , Michael Levin , Penousal Machado , Charles Ofria , Susan Stepney , Roger White

Many of the most important processes in cells take place on and across membranes. With the rise of an impressive array of powerful quantitative methods for characterizing these membranes, it is an opportune time to reflect on the structure…

Biomolecules · Quantitative Biology 2017-03-08 Rob Phillips

Nowadays, multiscale modelling is recognized as the most suitable way to study biological processes. Indeed, almost every phenomenon in nature exhibits a multiscale behaviour, i.e., it is the outcome of interactions that occur at different…

Formal Languages and Automata Theory · Computer Science 2011-08-18 Federico Buti , Massimo Callisto De Donato , Flavio Corradini , Emanuela Merelli , Luca Tesei

Biological membranes mainly consist of lipids and proteins. While the proteins have many functions as single molecules, the membrane as a whole displays physical properties that cannot be explained on the single molecule level. For example,…

Biological Physics · Physics 2009-06-09 Thomas Heimburg

We consider continuous-time consensus systems whose interactions satisfy a form or reciprocity that is not instantaneous, but happens over time. We show that these systems have certain desirable properties: They always converge…

Systems and Control · Computer Science 2015-10-20 Samuel Martin , Julien M. Hendrickx

Membrane computing is a branch of natural computingwhich abstracts fromthe structure and the functioning of living cells. The computation models obtained in the field of membrane computing are usually called P systems. P systems have been…

Computational Complexity · Computer Science 2023-06-22 Yu Jin , Bosheng Song , Yanyan Li , Ying Zhu

Because organisms are able to sense its passage, it is perhaps tempting to treat time as a sensory modality, akin to vision or audition. Indeed, certain features of sensory estimation, such as Weber's law, apply to timing and sensation…

Neurons and Cognition · Quantitative Biology 2025-04-01 Caroline Haimerl , Filipe S. Rodrigues , Joseph J. Paton

The cells and tissues that make up our body juggle contradictory mechanical demands. It is crucial for their survival to be able to withstand large mechanical loads, but it is equally crucial for them to produce forces and actively change…

Biological Physics · Physics 2019-03-22 Federica Burla , Yuval Mulla , Bart E. Vos , Anders Aufderhorst-Roberts , Gijsje H. Koenderink

This paper is a survey of extensions to finite automata theory to model real-time systems as well as systems exhibiting mixed discrete-continuous behavior. Real-time systems maintain a continuous and timely interaction with the environment,…

Formal Languages and Automata Theory · Computer Science 2018-11-27 Lakhan Shiva Kamireddy

The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological…

Cell Behavior · Quantitative Biology 2016-07-20 Pia Domschke , Dumitru Trucu , Alf Gerisch , Mark A. J. Chaplain

P systems with active membranes were used to generate languages, in the sense of languages associated with the structure of membrane systems. Here, we analyze the power of P systems with membrane creation and dissolution restricted to…

Distributed, Parallel, and Cluster Computing · Computer Science 2011-08-18 Rama Raghavan , H. Ramesh , Marian Gheorghe , Shankara Narayanan Krishna

Temporal modulation unlocks possibilities to dynamically control and modify the response of electromagnetic systems. Employing explicit dependencies of circuit or surface parameters on time enables the engineering of systems with…

Systems and Control · Electrical Eng. & Systems 2023-03-01 Grigorii Ptitcyn , Mohammad Sajjad Mirmoosa , Silvi Hrabar , Sergey Tretyakov

Do biological cells sense time by the number of their divisions, a process that ends at senescence? We consider the question "can the cell's perception of time be expressed through the length of the shortest telomere?" The answer is that…

Subcellular Processes · Quantitative Biology 2017-11-15 Zeev Schuss , Kimsy Tor , David Holcman

We consider a continuum mechanical model for the migration of multiple cell populations through parts of tissue separated by thin membranes. In this model, cells belonging to different populations may be characterised by different…

Analysis of PDEs · Mathematics 2021-09-28 Chiara Giverso , Tommaso Lorenzi , Luigi Preziosi

Biological cells are the prototypical example of active matter. Cells sense and respond to mechanical, chemical and electrical environmental stimuli with a range of behaviors, including dynamic changes in morphology and mechanical…

Computational Engineering, Finance, and Science · Computer Science 2017-02-28 Endre Somogyi , James A. Glazier

Cell biomechanics involve a great number of complex phenomena that are fundamental to the evolution of life itself and other associated processes, ranging from the very early stages of embryo-genesis to the maintenance of damaged structures…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Juan Olalla-Pombo , Alberto Badías , Miguel Ángel Sanz-Gómez , José María Benítez , Francisco Javier Montáns

The increasing relevance of areas such as real-time and embedded systems, pervasive computing, hybrid systems control, and biological and social systems modeling is bringing a growing attention to the temporal aspects of computing, not only…

General Literature · Computer Science 2013-08-15 Carlo A. Furia , Dino Mandrioli , Angelo Morzenti , Matteo Rossi
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