Related papers: Towards Biosensing Strategies Based on Biochemical…
Interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions (from molecules in gene regulatory…
Physical limit of molecular sensing has been extensively studied in biological systems. Biosensors are engineered equivalents of molecular sensors in living systems and play critical role in disease diagnosis and management. Investigation…
Experimental and theoretical analyses of the lactate dehydrogenase and glutathione reductase based enzymatic AND logic gates in which the enzymes and their substrates serve as logic inputs are performed. These two systems are examples of…
Reasoning about hypotheses and updating knowledge through empirical observations are central to scientific discovery. In this work, we applied logic-based machine learning methods to drive biological discovery by guiding experimentation.…
Synthetic active colloidal systems are being studied extensively because of the diverse and often unusual phenomena these nonequilibrium systems manifest, and their potential applications in fields ranging from biology to material science.…
Energy-efficient sensing with Physically-secure communication for bio-sensors on, around and within the Human Body is a major area of research today for development of low-cost healthcare, enabling continuous monitoring and/or secure,…
The Boolean algebra is the natural theoretical framework for a classical information treatment. The basic logical operations are usually performed using logic gates. In this Letter we demonstrate that NOT, OR and AND gates can be realized…
We realize a biochemical filtering process by introducing a buffer in a biocatalytic signal-transduction logic system based on the function of an enzyme, esterase. The input, ethyl butyrate, is converted into butyric acid-the output signal,…
We propose that the behaviour of non-linear media can be controlled automatically through coevolutionary systems. By extension, forms of unconventional computing, i.e., massively parallel non-linear computers, can be realised by such an…
We present a novel multi-modal bio-sensing platform capable of integrating multiple data streams for use in real-time applications. The system is composed of a central compute module and a companion headset. The compute node collects,…
The promising field of organic electronics has ushered in a new era of biosensing technology, offering a promising frontier for applications in both medical diagnostics and environmental monitoring. This review paper provides a…
We develop an approach aimed at optimizing the parameters of a network of biochemical logic gates for reduction of the "analog" noise buildup. Experiments for three coupled enzymatic AND gates are reported, illustrating our procedure.…
There is a growing trend in molecular and synthetic biology of using mechanistic (non machine learning) models to design biomolecular networks. Once designed, these networks need to be validated by experimental results to ensure the…
Biochemical reactions involving three or more reactants, called higher-molecular reactions, play an important role in theoretical systems and synthetic biology. In particular, such reactions underpin a variety of important bio-dynamical…
Quantum Hamiltonian Computing is a recent approach that uses quantum systems, in particular a single molecule, to perform computational tasks. Within this approach, we present explicit methods to construct logic gates using two different…
Stochasticity is a key characteristic of intracellular processes such as gene regulation and chemical signalling. Therefore, characterising stochastic effects in biochemical systems is essential to understand the complex dynamics of living…
The current biochemical information processing systems behave in a predetermined manner because all features are defined during the design phase. To make such unconventional computing systems reusable and programmable for biomedical…
Biocomputing technologies exploit biological communication mechanisms involving cell-cell signal propagation to perform computations. Researchers recently worked toward realising logic gates made by neurons to develop novel devices such as…
With the advancement of synthetic biology, several new tools have been conceptualized over the years as alternative treatments for current medical procedures. Most of those applications are applied to various chronic diseases. This work…
The control of manufacturing processes must satisfy high quality and efficiency requirements while meeting safety requirements. A broad spectrum of monitoring and control strategies, such as model- and optimization-based controllers, are…