We realize a biochemical filtering process by introducing a buffer in a biocatalytic signal-transduction logic system based on the function of an enzyme, esterase. The input, ethyl butyrate, is converted into butyric acid-the output signal, which in turn is measured by the drop in the pH value. The developed approach offers a versatile "network element" for increasing the complexity of biochemical information processing systems. Evaluation of an optimal regime for quality filtering is accomplished in the framework of a kinetic rate-equation model.
@article{arxiv.1011.3151,
title = {Towards Biochemical Filter with Sigmoidal Response to pH Changes: Buffered Biocatalytic Signal Transduction},
author = {Marcos Pita and Vladimir Privman and Mary A. Arugula and Dmitriy Melnikov and Vera Bocharova and Evgeny Katz},
journal= {arXiv preprint arXiv:1011.3151},
year = {2017}
}