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We propose a simple tractable pair hidden Markov model for pairwise sequence alignment that accounts for the presence of short tandem repeats. Using the framework of gain functions, we design several optimization criteria for decoding this…

Quantitative Methods · Quantitative Biology 2013-07-31 Michal Nánási , Tomáš Vinař , Broňa Brejová

Expectation maximisation (EM) is usually thought of as an unsupervised learning method for estimating the parameters of a mixture distribution, however it can also be used for supervised learning when class labels are available. As such, EM…

Machine Learning · Computer Science 2022-06-01 Graham W. Pulford

In spite of remarkable progress in machine learning techniques, the state-of-the-art machine learning algorithms often keep machines from real-time learning (online learning) due in part to computational complexity in parameter…

Neural and Evolutionary Computing · Computer Science 2017-11-27 Guhyun Kim , Vladimir Kornijcuk , Dohun Kim , Inho Kim , Jaewook Kim , Hyo Cheon Woo , Ji Hun Kim , Cheol Seong Hwang , Doo Seok Jeong

Inferring dynamics from time series is an important objective in data analysis. In particular, it is challenging to infer stochastic dynamics given incomplete data. We propose an expectation maximization (EM) algorithm that iterates between…

Data Analysis, Statistics and Probability · Physics 2021-08-25 Sangwon Lee , Vipul Periwal , Junghyo Jo

We consider the maximum likelihood (Viterbi) alignment of a hidden Markov model (HMM). In an HMM, the underlying Markov chain is usually hidden and the Viterbi alignment is often used as the estimate of it. This approach will be referred to…

Probability · Mathematics 2010-12-14 Kristi Kuljus , Jüri Lember

A novel decoding algorithm is developed for general quantum convolutional codes. Exploiting useful ideas from classical coding theory, the new decoder introduces two innovations that drastically reduce the decoding complexity compared to…

Quantum Physics · Physics 2015-03-13 Peiyu Tan , Jing Li

Deep learning models are trained and deployed in multiple domains. Increasing usage of deep learning models alarms the usage of memory consumed while computation by deep learning models. Existing approaches for reducing memory consumption…

Machine Learning · Computer Science 2021-10-25 Mahendran N

Stochastic models of biochemical reaction networks are widely used to capture intrinsic noise in cellular systems. The typical formulation of these models are based on Markov processes for which there is extensive research on efficient…

Molecular Networks · Quantitative Biology 2025-12-03 Thomas P. Steele , David J. Warne

Mixtures of Hidden Markov Models (MHMMs) are frequently used for clustering of sequential data. An important aspect of MHMMs, as of any clustering approach, is that they can be interpretable, allowing for novel insights to be gained from…

Artificial Intelligence · Computer Science 2021-03-24 Negar Safinianaini , Henrik Boström

Learning with hidden variables is a central challenge in probabilistic graphical models that has important implications for many real-life problems. The classical approach is using the Expectation Maximization (EM) algorithm. This…

Machine Learning · Computer Science 2012-12-12 Gal Elidan , Nir Friedman

Two major tasks in applications of hidden Markov models are to (i) compute distributions of summary statistics of the hidden state sequence, and (ii) decode the hidden state sequence. We describe finite Markov chain imbedding (FMCI) and…

Machine Learning · Statistics 2025-04-22 Zenia Elise Damgaard Bæk , Moisès Coll Macià , Laurits Skov , Asger Hobolth

Motivated by the unceasing interest in hidden Markov models (HMMs), this paper re-examines hidden path inference in these models, using primarily a risk-based framework. While the most common maximum a posteriori (MAP), or Viterbi, path…

Machine Learning · Statistics 2013-04-17 Jüri Lember , Alexey A. Koloydenko

Hyperparameter optimization (HPO) is an important step in machine learning (ML) model development, but common practices are archaic -- primarily relying on manual or grid searches. This is partly because adopting advanced HPO algorithms…

Machine Learning · Computer Science 2024-02-08 Sungduk Yu , Mike Pritchard , Po-Lun Ma , Balwinder Singh , Sam Silva

Power systems that need to integrate renewables at a large scale must account for the high levels of uncertainty introduced by these power sources. This can be accomplished with a system of many distributed grid-level storage devices.…

Optimization and Control · Mathematics 2020-02-04 Joseph L. Durante , Juliana Nascimento , Warren B. Powell

Hidden Markov models (HMMs) are characterized by an unobservable Markov chain and an observable process -- a noisy version of the hidden chain. Decoding the original signal from the noisy observations is one of the main goals in nearly all…

Methodology · Statistics 2026-05-19 Alexandre Mösching , Housen Li , Axel Munk

There are two common approaches for optimizing the performance of a machine: genetic algorithms and machine learning. A genetic algorithm is applied over many generations whereas machine learning works by applying feedback until the system…

Artificial Intelligence · Computer Science 2017-09-01 Leigh Sheneman , Arend Hintze

Inference in hidden Markov model has been challenging in terms of scalability due to dependencies in the observation data. In this paper, we utilize the inherent memory decay in hidden Markov models, such that the forward and backward…

Machine Learning · Statistics 2025-01-14 Felix X. -F. Ye , Yi-an Ma , Hong Qian

It has been found that stochastic algorithms often find good solutions much more rapidly than inherently-batch approaches. Indeed, a very useful rule of thumb is that often, when solving a machine learning problem, an iterative technique…

Machine Learning · Computer Science 2013-08-19 Andrew Cotter

As foundation models become more popular, there is a growing need to efficiently finetune them for downstream tasks. Although numerous adaptation methods have been proposed, they are designed to be efficient only in terms of how many…

Computer Vision and Pattern Recognition · Computer Science 2024-02-06 Otniel-Bogdan Mercea , Alexey Gritsenko , Cordelia Schmid , Anurag Arnab

The Viterbi algorithm is a key operator for structured sequence inference in modern data systems, with applications in trajectory analysis, online recommendation, and speech recognition. As these workloads increasingly migrate to…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-24 Ziheng Deng , Xue Liu , Jiantong Jiang , Yankai Li , Qingxu Deng , Xiaochun Yang